This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
产品简要
公司名称 :
Tocris Bioscience
产品类型 :
化学品
产品名称 :
SCH 79797 dihydrochloride
目录 :
1592/50
规格 :
50毫克
价格 :
1110美元
文章摘录数: 27
参考文献
Martin J, Sheehan J, Bratton B, Moore G, Mateus A, Li S, et al. A Dual-Mechanism Antibiotic Kills Gram-Negative Bacteria and Avoids Drug Resistance. Cell. 2020;181:1518-1532.e14 pubmed 出版商
Noskovičová N, Heinzelmann K, Burgstaller G, Behr J, Eickelberg O. Cub domain-containing protein 1 negatively regulates TGF-β signaling and myofibroblast differentiation. Am J Physiol Lung Cell Mol Physiol. 2018;314:L695-L707 pubmed 出版商
Zhang S, Liu Y, WANG Z, Liu J, Gu Z, Xu Q, et al. PAR1‑mediated c‑Jun activation promotes heat stress‑induced early stage apoptosis of human umbilical vein endothelial cells. Mol Med Rep. 2017;15:2595-2603 pubmed 出版商
Li Y, Yang W, Quinones Hinojosa A, Wang B, Xu S, Zhu W, et al. Interference with Protease-activated Receptor 1 Alleviates Neuronal Cell Death Induced by Lipopolysaccharide-Stimulated Microglial Cells through the PI3K/Akt Pathway. Sci Rep. 2016;6:38247 pubmed 出版商
Al Gwairi O, Osman N, Getachew R, Zheng W, Liang X, Kamato D, et al. Multiple Growth Factors, But Not VEGF, Stimulate Glycosaminoglycan Hyperelongation in Retinal Choroidal Endothelial Cells. Int J Biol Sci. 2016;12:1041-51 pubmed 出版商
Auvergne R, Wu C, Connell A, Au S, Cornwell A, Osipovitch M, et al. PAR1 inhibition suppresses the self-renewal and growth of A2B5-defined glioma progenitor cells and their derived gliomas in vivo. Oncogene. 2016;35:3817-28 pubmed 出版商
Carrim N, Arthur J, Hamilton J, Gardiner E, Andrews R, Moran N, et al. Thrombin-induced reactive oxygen species generation in platelets: A novel role for protease-activated receptor 4 and GPIbα. Redox Biol. 2015;6:640-647 pubmed 出版商
Gur Cohen S, Itkin T, Chakrabarty S, Graf C, Kollet O, Ludin A, et al. PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells. Nat Med. 2015;21:1307-17 pubmed 出版商
Otsuki T, Fujimoto D, Hirono Y, Goi T, Yamaguchi A. Thrombin conducts epithelial‑mesenchymal transition via protease‑activated receptor‑1 in human gastric cancer. Int J Oncol. 2014;45:2287-94 pubmed 出版商
Tripathi T, Abdi M, Alizadeh H. Protease-activated receptor 2 (PAR2) is upregulated by Acanthamoeba plasminogen activator (aPA) and induces proinflammatory cytokine in human corneal epithelial cells. Invest Ophthalmol Vis Sci. 2014;55:3912-21 pubmed 出版商
Yang H, Li T, Wei J, Zhang H, He S. Induction of tumor necrosis factor (TNF) release from subtypes of T cells by agonists of proteinase activated receptors. Mediators Inflamm. 2013;2013:165453 pubmed 出版商
Gadepalli R, Kotla S, Heckle M, Verma S, Singh N, Rao G. Novel role for p21-activated kinase 2 in thrombin-induced monocyte migration. J Biol Chem. 2013;288:30815-31 pubmed 出版商
Juncker Jensen A, Deryugina E, Rimann I, Zajac E, Kupriyanova T, Engelholm L, et al. Tumor MMP-1 activates endothelial PAR1 to facilitate vascular intravasation and metastatic dissemination. Cancer Res. 2013;73:4196-211 pubmed 出版商
Yan J, Manaenko A, Chen S, Klebe D, Ma Q, Caner B, et al. Role of SCH79797 in maintaining vascular integrity in rat model of subarachnoid hemorrhage. Stroke. 2013;44:1410-7 pubmed 出版商
Ganachari M, Guio H, Zhao N, Flores Villanueva P. Host gene-encoded severe lung TB: from genes to the potential pathways. Genes Immun. 2012;13:605-20 pubmed 出版商
Chen B, Friedman B, Whitney M, Winkle J, Lei I, Olson E, et al. Thrombin activity associated with neuronal damage during acute focal ischemia. J Neurosci. 2012;32:7622-31 pubmed 出版商
Scarisbrick I, Radulovic M, Burda J, Larson N, Blaber S, Giannini C, et al. Kallikrein 6 is a novel molecular trigger of reactive astrogliosis. Biol Chem. 2012;393:355-67 pubmed 出版商
Okamura Y, Schmidt R, Raschke I, Hintze M, Takeoka S, Egner A, et al. A few immobilized thrombins are sufficient for platelet spreading. Biophys J. 2011;100:1855-63 pubmed 出版商
Dowal L, Sim D, Dilks J, Blair P, Beaudry S, Denker B, et al. Identification of an antithrombotic allosteric modulator that acts through helix 8 of PAR1. Proc Natl Acad Sci U S A. 2011;108:2951-6 pubmed 出版商
Vidwan P, Pathak A, Sheth S, Huang J, Monroe D, Stouffer G. Activation of protease-activated receptors 3 and 4 accelerates tissue factor-induced thrombin generation on the surface of vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 2010;30:2587-96 pubmed 出版商
Fujimoto D, Hirono Y, Goi T, Katayama K, Matsukawa S, Yamaguchi A. The activation of Proteinase-Activated Receptor-1 (PAR1) mediates gastric cancer cell proliferation and invasion. BMC Cancer. 2010;10:443 pubmed 出版商
Lee E, Woo M, Moon P, Baek M, Choi I, Kim W, et al. Alpha-synuclein activates microglia by inducing the expressions of matrix metalloproteinases and the subsequent activation of protease-activated receptor-1. J Immunol. 2010;185:615-23 pubmed 出版商
Malik G, Knowles L, Dhir R, Xu S, Yang S, Ruoslahti E, et al. Plasma fibronectin promotes lung metastasis by contributions to fibrin clots and tumor cell invasion. Cancer Res. 2010;70:4327-34 pubmed 出版商
Yoshikawa Y, Hirayasu H, Tsuzuki S, Fushiki T. Granzyme A and thrombin differentially promote the release of interleukin-8 from alveolar epithelial A549 cells. Cytotechnology. 2010;62:325-32 pubmed 出版商
Blackburn J, Liu I, Coon C, Brinckerhoff C. A matrix metalloproteinase-1/protease activated receptor-1 signaling axis promotes melanoma invasion and metastasis. Oncogene. 2009;28:4237-48 pubmed 出版商
Popovic M, Laumonnier Y, Burysek L, Syrovets T, Simmet T. Thrombin-induced expression of endothelial CX3CL1 potentiates monocyte CCL2 production and transendothelial migration. J Leukoc Biol. 2008;84:215-23 pubmed 出版商
Ma L, Perini R, McKnight W, Dicay M, Klein A, Hollenberg M, et al. Proteinase-activated receptors 1 and 4 counter-regulate endostatin and VEGF release from human platelets. Proc Natl Acad Sci U S A. 2005;102:216-20 pubmed
产品信息
品牌 :
Tocris
master code :
1592
SKU号 :
1592/50
产品名称 :
SCH 79797 dihydrochloride
描述 :
Potent, selective non-peptide PAR1 antagonist
靶标 :
Protease-Activated Receptor Antagonists
类别 :
Small Molecules
单位尺寸 :
50毫克
纯度 :
99%
观察到的分子量 :
444.41
网址印刷 :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
功能细节 :
SCH 79797 dihydrochloride is a potent, selective non-peptide PAR1 receptor antagonist (IC50 = 70 nM). Inhibits haTRAP-induced- but not -thrombin-, ADP- or collagen-induced human platelet aggregation. Selectively blocks PAR1 agonist- or thrombin-induced increases in cytosolic Ca2+ in vascular smooth muscle cells. Also broad spectrum antibiotic. Kills bacteria by a dual action of inhibiting dihydrofolate reductase and interfering with bacterial cell membrane integrity.
catalog number base :
1592
extended description :
Potent, selective non-peptide PAR1 antagonist
化学品名文本 :
N3-Cyclopropyl-7-[[4-(1-methylethyl)phenyl]methyl]-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine dihydrochloride
配方 :
C 23 H 25 N 5。 2HCl
配方文本 :
C23H25N5.2HCl
cas num :
1216720-69-2
美元2021 :
1082
美元2022 :
1110美元
产品细节 :
Potent, selective non-peptide PAR1 antagonist
储存 :
Desiccate at RT
公司信息
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
公司总部: 英国