产品简要
公司名称 :
Tocris Bioscience
产品类型 :
化学品
产品名称 :
Rottlerin
目录 :
1610/10
规格 :
10 mg (also 50 mg)
价格 :
119美元
更多信息或购买 :
Tocris Bioscience 产品网页
文章摘录数: 6
参考文献
Pietras E, Mirantes Barbeito C, Fong S, Loeffler D, Kovtonyuk L, Zhang S, et al. Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal. Nat Cell Biol. 2016;18:607-18 pubmed 出版商
Shu Q, Hu Z, Huang C, Yu X, Fan H, Yang J, et al. Orexin-A promotes cell migration in cultured rat astrocytes via Ca2+-dependent PKCα and ERK1/2 signals. PLoS ONE. 2014;9:e95259 pubmed 出版商
Goldklang M, Perez Zoghbi J, Trischler J, Nkyimbeng T, Zakharov S, Shiomi T, et al. Treatment of experimental asthma using a single small molecule with anti-inflammatory and BK channel-activating properties. FASEB J. 2013;27:4975-86 pubmed 出版商
Seto S, Au A, Poon C, Zhang Q, Li R, Yeung J, et al. Acute simvastatin inhibits K ATP channels of porcine coronary artery myocytes. PLoS ONE. 2013;8:e66404 pubmed 出版商
Barbaric I, Jones M, Harley D, Gokhale P, Andrews P. High-content screening for chemical modulators of embryonal carcinoma cell differentiation and survival. J Biomol Screen. 2011;16:603-17 pubmed 出版商
Schaertl S, Prime M, Wityak J, Dominguez C, Munoz Sanjuan I, Pacifici R, et al. A profiling platform for the characterization of transglutaminase 2 (TG2) inhibitors. J Biomol Screen. 2010;15:478-87 pubmed 出版商
产品信息
品牌 :
Tocris
MasterCode :
1610
SKU号 :
1610/10
产品名称 :
Rottlerin
靶标 :
Protein Kinase C Inhibitors
类别 :
Small Molecules
单位尺寸 :
10 mg (also 50 mg)
纯度 :
95%
观察到的分子量 :
516.55
网址印刷 :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
功能细节 :
Originally reported to inhibit PKC isoforms. Also reported to inhibit CAM kinase III. However, recently shown to inhibit a wide range of protein kinases, and most potently to inhibit PRAK and MAPKAP-K2 (IC50 values are 1.9 and 5 u M respectively). Also shown to act as a direct mitochondrial uncoupler. Thought to stimulate autophagy by targeting upstream mTORC1 control pathways.
extended description :
Reported PKC inhibitor
化学品名文本 :
3 -[(8-Cinnamoyl-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)methyl]-2 ,4 ,6 -trihydroxy-5 -methylacetophenone
配方 :
C 30 H 28 O 8
配方文本 :
C30H28O8
cas num :
82-08-6
美元 :
119美元
产品细节 :
Reported PKC inhibitor
储存 :
存放在+4°C
更多信息或购买 :
Tocris Bioscience 产品网页
公司信息
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
公司总部: 英国