产品简要
公司名称 :
Tocris Bioscience
产品类型 :
化学品
产品名称 :
SB 431542
目录 :
1614
规格 :
1 mg (also 10 mg, 50 mg)
价格 :
147美元
更多信息或购买 :
文章摘录数: 257
参考文献
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de la Mare J, Jurgens T, Edkins A. Extracellular Hsp90 and TGFβ regulate adhesion, migration and anchorage independent growth in a paired colon cancer cell line model. BMC Cancer. 2017;17:202 pubmed 出版商
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Topalovski M, Hagopian M, Wang M, Brekken R. Hypoxia and Transforming Growth Factor ? Cooperate to Induce Fibulin-5 Expression in Pancreatic Cancer. J Biol Chem. 2016;291:22244-22252 pubmed
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产品信息
品牌 :
Tocris
master code :
1614
SKU号 :
1614/1
产品名称 :
SB 431542
描述 :
Potent, selective inhibitor of TGF- RI, ALK4 and ALK7
靶标 :
TGF-beta Receptor Inhibitors
类别 :
Small Molecules
单位尺寸 :
1 mg (also 10 mg, 50 mg)
纯度 :
99%
观察到的分子量 :
384.39
网址印刷 :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
功能细节 :
Potent and selective inhibitor of the transforming growth factor- (TGF- ) type I receptor/ALK5 (IC50 = 94 nM), and its relatives ALK4 and ALK7. Suppresses TGF- -induced proliferation of human osteosarcoma cells. Replaces SOX2 in reprogramming of fibroblasts into iPSCs. Stimulates proliferation, differentiation and sheet formation of ESC-derived endothelial cells. Inhibits TGF- -induced EMT, migration, invasion and VEGF secretion in several human cancer cell lines. . SB 431542 synthesized to cGMP guidelines also available.
catalog number base :
1614
产品关键词 :
Potent selective inhibitors inhibits TGF- RI TGF- TGF-betaRI TGFbRI TGFbR1 tgf-b1 ALK4 ALK7 Transforming Growth Factors Beta Receptors Receptor Serine/Threonine Kinases RSTKs SB431542 stem cells GlaxoSmithKline GSK EMT migration invasion epithe TGF-beta Receptors Stem Cell Proliferation Other Differentiation Products Stem Cell Reprogramming Organoids ALK 1614,
extended description :
Potent, selective inhibitor of TGF- RI, ALK4 and ALK7
化学品名文本 :
4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide
配方 :
C 22 H 16 N 4 O 3
配方文本 :
C22H16N4O3
cas num :
301836-41-9
2020美元 :
140
2021美元 :
147美元
储存 :
存放在RT
更多信息或购买 :
公司信息
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
公司总部: 英国