产品简要
公司名称 :
Tocris Bioscience
产品类型 :
化学品
产品名称 :
RS 102895 hydrochloride
目录 :
2089
规格 :
10 mg (also 50 mg)
价格 :
162美元
更多信息或购买 :
Tocris Bioscience 产品网页
文章摘录数: 5
参考文献
Teng K, Han J, Zhang X, Hsu S, He S, Wani N, et al. Blocking the CCL2-CCR2 Axis Using CCL2-Neutralizing Antibody Is an Effective Therapy for Hepatocellular Cancer in a Mouse Model. Mol Cancer Ther. 2017;16:312-322 pubmed 出版商
Cerri C, Genovesi S, Allegra M, Pistillo F, Püntener U, Guglielmotti A, et al. The Chemokine CCL2 Mediates the Seizure-enhancing Effects of Systemic Inflammation. J Neurosci. 2016;36:3777-88 pubmed 出版商
Maxwell P, Neisen J, Messenger J, Waugh D. Tumor-derived CXCL8 signaling augments stroma-derived CCL2-promoted proliferation and CXCL12-mediated invasion of PTEN-deficient prostate cancer cells. Oncotarget. 2014;5:4895-908 pubmed
Sennlaub F, Auvynet C, Calippe B, Lavalette S, Poupel L, Hu S, et al. CCR2(+) monocytes infiltrate atrophic lesions in age-related macular disease and mediate photoreceptor degeneration in experimental subretinal inflammation in Cx3cr1 deficient mice. EMBO Mol Med. 2013;5:1775-93 pubmed 出版商
Hung Y, Lai M, Tseng Y, Chou C, Lin Y. Monocyte chemoattractant protein-1 affects migration of hippocampal neural progenitors following status epilepticus in rats. J Neuroinflammation. 2013;10:11 pubmed 出版商
产品信息
品牌 :
Tocris
master code :
2089
SKU号 :
2089/10
产品名称 :
RS 102895 hydrochloride
描述 :
CCR2b chemokine receptor antagonist
靶标 :
Chemokine Receptor Antagonists
类别 :
Small Molecules
单位尺寸 :
10 mg (also 50 mg)
纯度 :
99%
观察到的分子量 :
426.86
网址印刷 :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
功能细节 :
CCR2-selective chemokine receptor antagonist (IC50 values are 0.36 and 17.8 u M for inhibition of human recombinant CCR2b and CCR1 receptors respectively). Blocks MCP-1-stimulated calcium influx and chemotaxis with IC50 values of 32 nM and 1.7 u M respectively. Also inhibits 1A, 1D and 5-HT1A receptors.
catalog number base :
2089
产品关键词 :
CCR2b chemokine receptor antagonists Chemokine Receptors RS102895 hydrochloride Chemokine CC Receptors 2089,
extended description :
CCR2b chemokine receptor antagonist
化学品名文本 :
1 -[2-[4-(Trifluoromethyl)phenyl]ethyl]-spiro[4H-3,1-benzoxazine-4,4 -piperidin]-2(1H)-one hydrochloride
配方 :
C 21 H 21 F 3 N 2 O 2。 氯化氢
配方文本 :
C21H21F3N2O2.氯化氢
cas num :
1173022-16-6
2020美元 :
155
2021美元 :
162美元
储存 :
Desiccate at RT
更多信息或购买 :
Tocris Bioscience 产品网页
公司信息
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
公司总部: 英国