产品简要
公司名称 :
Tocris Bioscience
产品类型 :
化学品
产品名称 :
API-2
目录 :
2151/10
规格 :
10毫克
价格 :
396美元
更多信息或购买 :
文章摘录数: 17
参考文献 |
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Sunters A, Armstrong V, Zaman G, Kypta R, Kawano Y, Lanyon L, et al. Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of insulin-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 r. J Biol Chem. 2010;285:8743-58 pubmed 出版商
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Madhunapantula S, Sharma A, Robertson G. PRAS40 deregulates apoptosis in malignant melanoma. Cancer Res. 2007;67:3626-36 pubmed
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产品信息
品牌 :
Tocris
MasterCode :
2151
SKU号 :
2151/10
产品名称 :
API-2
靶标 :
Akt (Protein Kinase B) Inhibitors
类别 :
Small Molecules
单位尺寸 :
10毫克
纯度 :
99%
观察到的分子量 :
320.31
网址印刷 :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
功能细节 :
API-2 is a selective inhibitor of Akt (protein kinase B) signaling; displays minimal inhibition of PKC, PKA, SGK and p38 pathways. Inhibits phosphorylation and activation of downstream targets of Akt including Bad, GSK-3 and AFX. Induces apoptosis and growth arrest in vitro , preferentially in human cancer cells with elevated levels of Akt. Potently and selectively inhibits growth of Akt-overexpressing tumors in mice. Inhibits DNA synthesis and displays antiviral activity against HIV-1 and -2.
extended description :
Selective inhibitor of Akt/PKB signaling. Antitumor and antiviral
化学品名文本 :
1,5-Dihydro-5-methyl-1- -D-ribofuranosyl-1,4,5,6,8-pentaazaacenaphthylen-3-amine
配方 :
C 13 H 16 N 6 O 4
配方文本 :
C13H16N6O4
cas num :
35943-35-2
美元 :
396美元
产品细节 :
Selective inhibitor of Akt/PKB signaling. Antitumor and antiviral
别名 :
Triciribine, NSC 154020, TCN
储存 :
存放在RT
更多信息或购买 :
公司信息
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com800-343-7475
公司总部: 英国