产品简要
公司名称 :
Tocris Bioscience
产品类型 :
化学品
产品名称 :
API-2
目录 :
2151/10
规格 :
10毫克
价格 :
307美元
更多信息或购买 :
文章摘录数: 17
参考文献
Yuan X, Cao X, Yang S. IFT80 is required for stem cell proliferation, differentiation, and odontoblast polarization during tooth development. Cell Death Dis. 2019;10:63 pubmed 出版商
Suarez C, Wu J, Badve S, Sparano J, Kaliney W, Littlepage L. The AKT inhibitor triciribine in combination with paclitaxel has order-specific efficacy against Zfp217-induced breast cancer chemoresistance. Oncotarget. 2017;8:108534-108547 pubmed 出版商
Ali R, Samman N, Al Zahrani H, Nehdi A, Rahman S, Khan A, et al. Isolation and characterization of a new naturally immortalized human breast carcinoma cell line, KAIMRC1. BMC Cancer. 2017;17:803 pubmed 出版商
Arqués O, Chicote I, Puig I, Tenbaum S, Argilés G, Dienstmann R, et al. Tankyrase Inhibition Blocks Wnt/β-Catenin Pathway and Reverts Resistance to PI3K and AKT Inhibitors in the Treatment of Colorectal Cancer. Clin Cancer Res. 2016;22:644-56 pubmed 出版商
Kana K, Song H, Laschinger C, Zandstra P, Radisic M. PI3K Phosphorylation Is Linked to Improved Electrical Excitability in an In Vitro Engineered Heart Tissue Disease Model System. Tissue Eng Part A. 2015;21:2379-89 pubmed 出版商
Rosenberg S, Niglio S, Salehomoum N, Chan J, Jeong B, Wen Y, et al. Targeting Glutamatergic Signaling and the PI3 Kinase Pathway to Halt Melanoma Progression. Transl Oncol. 2015;8:1-9 pubmed 出版商
Shravah J, Wang B, Pavlovic M, Kumar U, Chen D, Luo H, et al. Propofol mediates signal transducer and activator of transcription 3 activation and crosstalk with phosphoinositide 3-kinase/AKT. JAKSTAT. 2014;3:e29554 pubmed 出版商
Kuo T, Chen T, Yan S, Foo F, Ching C, McQueen A, et al. Repression of glucocorticoid-stimulated angiopoietin-like 4 gene transcription by insulin. J Lipid Res. 2014;55:919-28 pubmed 出版商
Robertson A, Coluccio A, Jensen S, Rydlizky K, Coffman J. Sea urchin akt activity is Runx-dependent and required for post-cleavage stage cell division. Biol Open. 2013;2:472-8 pubmed 出版商
Woo M, Xue K, Liu J, McBride H, Tsang B. Calpain-mediated processing of p53-associated parkin-like cytoplasmic protein (PARC) affects chemosensitivity of human ovarian cancer cells by promoting p53 subcellular trafficking. J Biol Chem. 2012;287:3963-75 pubmed 出版商
Duan S, Skaar J, Kuchay S, Toschi A, Kanarek N, Ben Neriah Y, et al. mTOR generates an auto-amplification loop by triggering the ?TrCP- and CK1?-dependent degradation of DEPTOR. Mol Cell. 2011;44:317-24 pubmed 出版商
Barber A, Sentman C. NKG2D receptor regulates human effector T-cell cytokine production. Blood. 2011;117:6571-81 pubmed 出版商
Jackson C, Welch H, Bellamy T. Control of cerebellar long-term potentiation by P-Rex-family guanine-nucleotide exchange factors and phosphoinositide 3-kinase. PLoS ONE. 2010;5:e11962 pubmed 出版商
Liu S, Shen H, Xu M, Liu O, Zhao L, Liu S, et al. FRP inhibits ox-LDL-induced endothelial cell apoptosis through an Akt-NF-{kappa}B-Bcl-2 pathway and inhibits endothelial cell apoptosis in an apoE-knockout mouse model. Am J Physiol Endocrinol Metab. 2010;299:E351-63 pubmed 出版商
Sunters A, Armstrong V, Zaman G, Kypta R, Kawano Y, Lanyon L, et al. Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of insulin-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 r. J Biol Chem. 2010;285:8743-58 pubmed 出版商
Roselli F, Hutzler P, Wegerich Y, Livrea P, Almeida O. Disassembly of shank and homer synaptic clusters is driven by soluble beta-amyloid(1-40) through divergent NMDAR-dependent signalling pathways. PLoS ONE. 2009;4:e6011 pubmed 出版商
Madhunapantula S, Sharma A, Robertson G. PRAS40 deregulates apoptosis in malignant melanoma. Cancer Res. 2007;67:3626-36 pubmed
图像
图像 1 :
Tocris Bioscience 2151/10 图像 1
Cat.No. 2151 - API-2 C13H16N6O4 CAS No. 35943-35-2
产品信息
品牌 :
Tocris
SKU号 :
2151/10
Ranking :
0.071
产品名称 :
API-2
单位尺寸 :
10毫克
描述 :
Selective inhibitor of Akt/PKB signaling. Antitumor and antiviral
靶标 :
Akt (Protein Kinase B) Inhibitors
类别 :
Small Molecules
纯度 :
0.99
观察到的分子量 :
320.31
网址印刷 :
?utm_source=labome utm_medium=referral utm_campaign=product utm_term=smallmolecules
功能细节 :
Selective inhibitor of Akt (protein kinase B) signaling; displays minimal inhibition of PKC, PKA, SGK and p38 pathways. Inhibits phosphorylation and activation of downstream targets of Akt including Bad, GSK-3 span class='symbol' beta; /span and AFX. Induces apoptosis and growth arrest in vitro /em , preferentially in human cancer cells with elevated levels of Akt. Potently and selectively inhibits growth of Akt-overexpressing tumors in mice. Inhibits DNA synthesis and displays antiviral activity against HIV-1 and -2.
catalog number base :
2151
extended description :
Selective inhibitor of Akt/PKB signaling. Antitumor and antiviral
化学品名文本 :
1,5-Dihydro-5-methyl-1- -D-ribofuranosyl-1,4,5,6,8-pentaazaacenaphthylen-3-amine
配方 :
C sub /sub sub /sub sub /sub sub /sub
配方文本 :
C13H16N6O4
cas num :
35943-35-2
2020 Proposedprice USD :
307美元
产品细节 :
Selective inhibitor of Akt/PKB signaling. Antitumor and antiviral
别名 :
Triciribine, NSC 154020, TCN
储存 :
存放在RT
更多信息或购买 :
公司信息
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
公司总部: 英国