产品简要
公司名称 :
Tocris Bioscience
产品类型 :
化学品
产品名称 :
MRS 2365
目录 :
2157/1
规格 :
1毫克
价格 :
482美元
更多信息或购买 :
文章摘录数: 11
参考文献
Zhang W, Bonadiman A, Ciorraga M, Benitez M, Garrido J. P2Y1 Purinergic Receptor Modulate Axon Initial Segment Initial Development. Front Cell Neurosci. 2019;13:152 pubmed 出版商
Stefanini L, Paul D, Robledo R, Chan E, Getz T, Campbell R, et al. RASA3 is a critical inhibitor of RAP1-dependent platelet activation. J Clin Invest. 2015;125:1419-32 pubmed 出版商
Kurahashi M, MUTAFOVA YAMBOLIEVA V, Koh S, Sanders K. Platelet-derived growth factor receptor-?-positive cells and not smooth muscle cells mediate purinergic hyperpolarization in murine colonic muscles. Am J Physiol Cell Physiol. 2014;307:C561-70 pubmed 出版商
Koch H, Bespalov A, Drescher K, Franke H, Krügel U. Impaired cognition after stimulation of P2Y1 receptors in the rat medial prefrontal cortex. Neuropsychopharmacology. 2015;40:305-14 pubmed 出版商
Ilatovskaya D, Palygin O, Levchenko V, Staruschenko A. Pharmacological characterization of the P2 receptors profile in the podocytes of the freshly isolated rat glomeruli. Am J Physiol Cell Physiol. 2013;305:C1050-9 pubmed 出版商
Shabir S, Cross W, Kirkwood L, Pearson J, Appleby P, Walker D, et al. Functional expression of purinergic P2 receptors and transient receptor potential channels by the human urothelium. Am J Physiol Renal Physiol. 2013;305:F396-406 pubmed 出版商
Gao Z, Wei Q, Jayasekara M, Jacobson K. The role of P2Y(14) and other P2Y receptors in degranulation of human LAD2 mast cells. Purinergic Signal. 2013;9:31-40 pubmed 出版商
Chandaka G, Salzer I, Drobny H, Boehm S, Schicker K. Facilitation of transmitter release from rat sympathetic neurons via presynaptic P2Y(1) receptors. Br J Pharmacol. 2011;164:1522-33 pubmed 出版商
Kuboyama K, Harada H, Tozaki Saitoh H, Tsuda M, Ushijima K, Inoue K. Astrocytic P2Y(1) receptor is involved in the regulation of cytokine/chemokine transcription and cerebral damage in a rat model of cerebral ischemia. J Cereb Blood Flow Metab. 2011;31:1930-41 pubmed 出版商
Filippov A, Simon J, Barnard E, Brown D. The scaffold protein NHERF2 determines the coupling of P2Y1 nucleotide and mGluR5 glutamate receptor to different ion channels in neurons. J Neurosci. 2010;30:11068-72 pubmed 出版商
Mamedova L, Wang R, Besada P, Liang B, Jacobson K. Attenuation of apoptosis in vitro and ischemia/reperfusion injury in vivo in mouse skeletal muscle by P2Y6 receptor activation. Pharmacol Res. 2008;58:232-9 pubmed 出版商
产品信息
品牌 :
Tocris
MasterCode :
2157
SKU号 :
2157/1
产品名称 :
MRS 2365
靶标 :
P2Y Receptor Agonists
类别 :
Small Molecules
单位尺寸 :
1毫克
纯度 :
98%
观察到的分子量 :
549.28
网址印刷 :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
功能细节 :
MRS 2365 is a highly potent, selective P2Y1 receptor agonist (EC50 = 0.4 nM). Displays no activity at P2Y12 receptors and only very low agonist activity at P2Y13 receptors (at concentrations up to 1 u M). Increases the upregulation of NTPDase1 by ATP S.
extended description :
Highly potent and selective P2Y1 agonist
化学品名文本 :
[[(1R,2R,3S,4R,5S)-4-[6-Amino-2-(methylthio)-9H-purin-9-yl]-2,3-dihydroxybicyclo[3.1.0]hex-1-yl]methyl] diphosphoric acid mono ester trisodium salt
配方 :
C 13 H 16 N 5 O 9 P 2 SNa 3
配方文本 :
C13H16N5O9P2SNa3
美元 :
482美元
产品细节 :
Highly potent and selective P2Y1 agonist
储存 :
存放在-20°C
更多信息或购买 :
公司信息
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
公司总部: 英国