化学品

Ro 08-2750

2272/1

1 mg (also 10 mg, 50 mg)

127美元

2272

2272/1

Ro 08-2750

Trk Receptor Inhibitors

Small Molecules

1 mg (also 10 mg, 50 mg)

95%

270.24

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Ro 08-2750 is a non-peptide inhibitor of NGF that binds the NGF dimer (KD ~ 1 u M) possibly causing a conformational change. Selectively inhibits binding of NGF to p75NTR at submicromolar concentrations, and to both p75NTR and TrkA at concentrations 5 u M. Prevents NGF-induced apoptosis in SK-N-MC cells. Suppresses cancer cell proliferation via regulation of Hippo signaling aand YAP phosphorylation.

Inhibits NGF binding to p75NTR and TrkA

2,3,4,10-Tetrahydro-7,10-dimethyl-2,4-dioxobenzo[g]pteridine-8-carboxaldehyde

C 13 H 10 N 4 O 3

C13H10N4O3

37854-59-4

127美元

Inhibits NGF binding to p75NTR and TrkA

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