产品简要
公司名称 :
Tocris Bioscience
产品类型 :
化学品
产品名称 :
Go 6983
目录 :
2285/1
规格 :
1 mg (also 10 mg)
价格 :
147美元
更多信息或购买 :
文章摘录数: 26
参考文献
Mclaurin J, Weiner O. Multiple sources of signal amplification within the B-cell Ras/MAPK pathway. Mol Biol Cell. 2019;30:1610-1620 pubmed 出版商
Rostovskaya M, Stirparo G, Smith A. Capacitation of human naïve pluripotent stem cells for multi-lineage differentiation. Development. 2019;146: pubmed 出版商
Messmer T, von Meyenn F, Savino A, Santos F, Mohammed H, Lun A, et al. Transcriptional Heterogeneity in Naive and Primed Human Pluripotent Stem Cells at Single-Cell Resolution. Cell Rep. 2019;26:815-824.e4 pubmed 出版商
Schaffer T, Smith J, Cook E, Phan T, Margolis S. PKCε Inhibits Neuronal Dendritic Spine Development through Dual Phosphorylation of Ephexin5. Cell Rep. 2018;25:2470-2483.e8 pubmed 出版商
Liu T, Shi Y, Chan M, Peng G, Zhang Q, Sun X, et al. Developmental protein kinase C hyper-activation results in microcephaly and behavioral abnormalities in zebrafish. Transl Psychiatry. 2018;8:232 pubmed 出版商
Fang F, Xia N, Angulo B, Carey J, Cady Z, Durruthy Durruthy J, et al. A distinct isoform of ZNF207 controls self-renewal and pluripotency of human embryonic stem cells. Nat Commun. 2018;9:4384 pubmed 出版商
Carriba P, Davies A. CD40 is a major regulator of dendrite growth from developing excitatory and inhibitory neurons. elife. 2017;6: pubmed 出版商
Augustin H, McGourty K, Allen M, Madem S, Adcott J, Kerr F, et al. Reduced insulin signaling maintains electrical transmission in a neural circuit in aging flies. PLoS Biol. 2017;15:e2001655 pubmed 出版商
Zhang Z, Meszaros G, He W, Xu Y, de Fatima Magliarelli H, Mailly L, et al. Protein kinase D at the Golgi controls NLRP3 inflammasome activation. J Exp Med. 2017;214:2671-2693 pubmed 出版商
Tuvikene J, Pruunsild P, Orav E, Esvald E, Timmusk T. AP-1 Transcription Factors Mediate BDNF-Positive Feedback Loop in Cortical Neurons. J Neurosci. 2016;36:1290-305 pubmed 出版商
Li X, Rhee D, Malhotra R, Mayeur C, Hurst L, Ager E, et al. Progesterone receptor membrane component-1 regulates hepcidin biosynthesis. J Clin Invest. 2016;126:389-401 pubmed 出版商
Shakiba N, White C, Lipsitz Y, Yachie Kinoshita A, Tonge P, Hussein S, et al. CD24 tracks divergent pluripotent states in mouse and human cells. Nat Commun. 2015;6:7329 pubmed 出版商
Devinney M, Fields D, Huxtable A, Peterson T, Dale E, Mitchell G. Phrenic long-term facilitation requires PKCθ activity within phrenic motor neurons. J Neurosci. 2015;35:8107-17 pubmed 出版商
Toda A, Huganir R. Regulation of AMPA receptor phosphorylation by the neuropeptide PACAP38. Proc Natl Acad Sci U S A. 2015;112:6712-7 pubmed 出版商
Kuan C, Yee Y, See Too W, Few L. Ets and GATA transcription factors play a critical role in PMA-mediated repression of the ckβ promoter via the protein kinase C signaling pathway. PLoS ONE. 2014;9:e113485 pubmed 出版商
Yi C, Allen J, Russo B, Lee S, Heindl J, Baxt L, et al. Systematic analysis of bacterial effector-postsynaptic density 95/disc large/zonula occludens-1 (PDZ) domain interactions demonstrates Shigella OspE protein promotes protein kinase C activation via PDLIM proteins. J Biol Chem. 2014;289:30101-13 pubmed 出版商
Cavaliere F, Benito Muñoz M, Panicker M, Matute C. NMDA modulates oligodendrocyte differentiation of subventricular zone cells through PKC activation. Front Cell Neurosci. 2013;7:261 pubmed 出版商
Gafni O, Weinberger L, Mansour A, Manor Y, Chomsky E, Ben Yosef D, et al. Derivation of novel human ground state naive pluripotent stem cells. Nature. 2013;504:282-6 pubmed 出版商
Pakpour N, Camp L, Smithers H, Wang B, Tu Z, Nadler S, et al. Protein kinase C-dependent signaling controls the midgut epithelial barrier to malaria parasite infection in anopheline mosquitoes. PLoS ONE. 2013;8:e76535 pubmed 出版商
van Vliet S, Vuist I, Lenos K, Tefsen B, Kalay H, Garcia Vallejo J, et al. Human T cell activation results in extracellular signal-regulated kinase (ERK)-calcineurin-dependent exposure of Tn antigen on the cell surface and binding of the macrophage galactose-type lectin (MGL). J Biol Chem. 2013;288:27519-32 pubmed 出版商
Rajendran G, Dutta D, Hong J, Paul A, Saha B, Mahato B, et al. Inhibition of protein kinase C signaling maintains rat embryonic stem cell pluripotency. J Biol Chem. 2013;288:24351-62 pubmed 出版商
Atwood S, Li M, Lee A, Tang J, Oro A. GLI activation by atypical protein kinase C ?/? regulates the growth of basal cell carcinomas. Nature. 2013;494:484-8 pubmed 出版商
Garrett A, Schreiner D, Lobas M, Weiner J. ?-protocadherins control cortical dendrite arborization by regulating the activity of a FAK/PKC/MARCKS signaling pathway. Neuron. 2012;74:269-76 pubmed 出版商
Scarisbrick I, Radulovic M, Burda J, Larson N, Blaber S, Giannini C, et al. Kallikrein 6 is a novel molecular trigger of reactive astrogliosis. Biol Chem. 2012;393:355-67 pubmed 出版商
Baskin R, Sayeski P. Angiotensin II mediates cell survival through upregulation and activation of the serum and glucocorticoid inducible kinase 1. Cell Signal. 2012;24:435-42 pubmed 出版商
Dutta D, Ray S, Home P, Larson M, Wolfe M, Paul S. Self-renewal versus lineage commitment of embryonic stem cells: protein kinase C signaling shifts the balance. Stem Cells. 2011;29:618-28 pubmed 出版商
产品信息
品牌 :
Tocris
MasterCode :
2285
SKU号 :
2285/1
产品名称 :
Go 6983
靶标 :
Protein Kinase C Inhibitors
类别 :
Small Molecules
单位尺寸 :
1 mg (also 10 mg)
纯度 :
98%
观察到的分子量 :
442.51
网址印刷 :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
功能细节 :
Go 6983 is a broad spectrum protein kinase C (PKC) inhibitor (IC50 values are 7, 7, 6, 10, 60 and 20000 nM for PKC , PKC , PKC , PKC , PKC and PKC u respectively). Displays cardioprotective properties; reduces polymorphonuclear leukocyte adherence and infiltration following myocardial ischemia/reperfusion injury. Optimizes na ve human pluripotent stem cell growth and viability following na ve cell derivation from primed ESCs and iPSCs using na ve human stem cell medium (NHSM).
extended description :
Broad spectrum PKC inhibitor
化学品名文本 :
3-[1-[3-(Dimethylamino)propyl]-5-methoxy-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione
配方 :
C 26 H 26 N 4 O 3
配方文本 :
C26H26N4O3
cas num :
133053-19-7
美元 :
147美元
产品细节 :
Broad spectrum PKC inhibitor
别名 :
Goe 6983
储存 :
存放在-20°C
更多信息或购买 :
公司信息
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
公司总部: 英国