产品简要
公司名称 :
Tocris Bioscience
产品类型 :
化学品
产品名称 :
RS 504393
目录 :
2517
规格 :
10毫克
价格 :
229美元
更多信息或购买 :
文章摘录数: 15
参考文献
Tong Y, Zhou L, Yang L, Guo P, Cao Y, Qin F, et al. Concomitant type I IFN and M-CSF signaling reprograms monocyte differentiation and drives pro-tumoral arginase production. EBioMedicine. 2019;39:132-144 pubmed 出版商
Linde N, Casanova Acebes M, Sosa M, Mortha A, Rahman A, Farias E, et al. Macrophages orchestrate breast cancer early dissemination and metastasis. Nat Commun. 2018;9:21 pubmed 出版商
Kwiatkowski K, Piotrowska A, Rojewska E, Makuch W, Mika J. The RS504393 Influences the Level of Nociceptive Factors and Enhances Opioid Analgesic Potency in Neuropathic Rats. J Neuroimmune Pharmacol. 2017;12:402-419 pubmed 出版商
Lu W, Tang Y, Zhang Z, Zhang X, Yao Y, Fu C, et al. Inhibiting the mobilization of Ly6C(high) monocytes after acute myocardial infarction enhances the efficiency of mesenchymal stromal cell transplantation and curbs myocardial remodeling. Am J Transl Res. 2015;7:587-97 pubmed
Ayoub M, Zhang Y, Kelly R, See H, Johnstone E, McCall E, et al. Functional interaction between angiotensin II receptor type 1 and chemokine (C-C motif) receptor 2 with implications for chronic kidney disease. PLoS ONE. 2015;10:e0119803 pubmed 出版商
Mazumdar S, Arendt L, Phillips S, Sedic M, Kuperwasser C, Gill G. CoREST1 promotes tumor formation and tumor stroma interactions in a mouse model of breast cancer. PLoS ONE. 2015;10:e0121281 pubmed 出版商
Lourenço S, Teixeira V, Kalber T, José R, Floto R, Janes S. Macrophage migration inhibitory factor-CXCR4 is the dominant chemotactic axis in human mesenchymal stem cell recruitment to tumors. J Immunol. 2015;194:3463-74 pubmed 出版商
Matsubara K, Matsushita Y, Sakai K, Kano F, Kondo M, Noda M, et al. Secreted ectodomain of sialic acid-binding Ig-like lectin-9 and monocyte chemoattractant protein-1 promote recovery after rat spinal cord injury by altering macrophage polarity. J Neurosci. 2015;35:2452-64 pubmed 出版商
Kim J, Kim W, Le H, Moon U, Tran V, Kim H, et al. IL-33-induced hematopoietic stem and progenitor cell mobilization depends upon CCR2. J Immunol. 2014;193:3792-802 pubmed 出版商
Arendt L, McCready J, Keller P, Baker D, Naber S, Seewaldt V, et al. Obesity promotes breast cancer by CCL2-mediated macrophage recruitment and angiogenesis. Cancer Res. 2013;73:6080-93 pubmed 出版商
Arms L, Girard B, Malley S, Vizzard M. Expression and function of CCL2/CCR2 in rat micturition reflexes and somatic sensitivity with urinary bladder inflammation. Am J Physiol Renal Physiol. 2013;305:F111-22 pubmed 出版商
Miller R, Tran P, Das R, Ghoreishi Haack N, Ren D, Miller R, et al. CCR2 chemokine receptor signaling mediates pain in experimental osteoarthritis. Proc Natl Acad Sci U S A. 2012;109:20602-7 pubmed 出版商
Zhang Z, Dong Y, Lu Y, Cao S, Zhao Z, Gao Y. Chemokine CCL2 and its receptor CCR2 in the medullary dorsal horn are involved in trigeminal neuropathic pain. J Neuroinflammation. 2012;9:136 pubmed 出版商
Simonson M, Ismail Beigi F. Endothelin-1 increases collagen accumulation in renal mesangial cells by stimulating a chemokine and cytokine autocrine signaling loop. J Biol Chem. 2011;286:11003-8 pubmed 出版商
Yang S, IglayReger H, Kadouh H, Bodary P. Inhibition of the chemokine (C-C motif) ligand 2/chemokine (C-C motif) receptor 2 pathway attenuates hyperglycaemia and inflammation in a mouse model of hepatic steatosis and lipoatrophy. Diabetologia. 2009;52:972-81 pubmed 出版商
产品信息
品牌 :
Tocris
master code :
2517
SKU号 :
2517/10
产品名称 :
RS 504393
描述 :
Highly selective CCR2 chemokine receptor antagonist
靶标 :
Chemokine Receptor Antagonists
类别 :
Small Molecules
单位尺寸 :
10毫克
纯度 :
99%
观察到的分子量 :
417.5
网址印刷 :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
功能细节 :
Extremely selective CCR2 chemokine receptor antagonist (IC50 values are 98 nM and 100 u M for inhibition of human recombinant CCR2b and CCR1 receptors respectively). Inhibits MCP-1 chemotaxis (IC50 = 330 nM) and ischemia-reperfusion injury in kidneys.
catalog number base :
2517
产品关键词 :
selective CCR2 chemokine receptor antagonists CXCR Chemokine Receptors RS504393 Chemokine CC Receptors 2517,
extended description :
Highly selective CCR2 chemokine receptor antagonist
化学品名文本 :
6-Methyl-1 -[2-(5-methyl-2-phenyl-4-oxazolyl)ethyl]-spiro[4H-3,1-benzoxazine-4,4 -piperidin]-2(1H)-one
配方 :
C 25 H 27 N 3 O 3
配方文本 :
C25H27N3O3
cas num :
300816-15-3
2020美元 :
220
2021美元 :
229美元
储存 :
存放在+4°C
更多信息或购买 :
公司信息
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
公司总部: 英国