产品简要
公司名称 :
Tocris Bioscience
产品类型 :
化学品
产品名称 :
10-DEBC hydrochloride
目录 :
2558/10
规格 :
10 mg (also 50 mg)
价格 :
182美元
更多信息或购买 :
Tocris Bioscience 产品网页
文章摘录数: 6
参考文献
Waltero C, de Abreu L, Alonso T, Nunes da Fonseca R, da Silva Vaz I, Logullo C. TOR as a Regulatory Target in Rhipicephalus microplus Embryogenesis. Front Physiol. 2019;10:965 pubmed 出版商
Ali R, Samman N, Al Zahrani H, Nehdi A, Rahman S, Khan A, et al. Isolation and characterization of a new naturally immortalized human breast carcinoma cell line, KAIMRC1. BMC Cancer. 2017;17:803 pubmed 出版商
Liddell J, Lehtonen S, Duncan C, Keksa Goldsteine V, Levonen A, Goldsteins G, et al. Pyrrolidine dithiocarbamate activates the Nrf2 pathway in astrocytes. J Neuroinflammation. 2016;13:49 pubmed 出版商
Sokołowska P, Urbańska A, Biegańska K, Wagner W, Ciszewski W, Namiecinska M, et al. Orexins protect neuronal cell cultures against hypoxic stress: an involvement of Akt signaling. J Mol Neurosci. 2014;52:48-55 pubmed 出版商
Goodnough J, Ramos E, Nemeth E, Ganz T. Inhibition of hepcidin transcription by growth factors. Hepatology. 2012;56:291-9 pubmed 出版商
Gangoiti P, Bernacchioni C, Donati C, Cencetti F, Ouro A, Gomez Munoz A, et al. Ceramide 1-phosphate stimulates proliferation of C2C12 myoblasts. Biochimie. 2012;94:597-607 pubmed 出版商
产品信息
品牌 :
Tocris, a Bio-Techne Brand
catalog number base :
2558
SKU号 :
2558/10
产品名称 :
10-DEBC hydrochloride
描述 :
Selective Akt/PKB inhibitor
靶标 :
Akt (Protein Kinase B) Inhibitors
类别 :
Small Molecules
单位尺寸 :
10 mg (also 50 mg)
纯度 :
99%
观察到的分子量 :
381.34
网址印刷 :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
功能细节 :
10-DEBC hydrochloride is a selective inhibitor of Akt/PKB. Inhibits IGF-1-stimulated phosphorylation and activation of Akt (complete inhibition at 2.5 u M), suppressing downstream activation of mTOR, p70 S6 kinase and S6 ribosomal protein. Shows no activity at PDK1, SGK1 or PI 3-kinase. Inhibits cell growth (IC50 ~ 2-6 u M) and induces apoptosis in rhabdomyosarcoma cells.
extended description :
Selective Akt/PKB inhibitor
化学品名文本 :
10-[4 -(N,N-Diethylamino)butyl]-2-chlorophenoxazine hydrochloride
配方 :
C 20 H 25 N 2 OCl.氯化氢
配方文本 :
C20H25N2OCl.氯化氢
cas num :
925681-41-0
美元 :
182美元
产品细节 :
Selective Akt/PKB inhibitor
别名 :
Akt Inhibitor X
储存 :
Desiccate at +4°C
更多信息或购买 :
Tocris Bioscience 产品网页
公司信息
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
公司总部: 英国