产品简要
公司名称 :
Tocris Bioscience
产品类型 :
化学品
产品名称 :
TPCA-1
目录 :
2559/10
规格 :
10毫克
价格 :
323美元
更多信息或购买 :
Tocris Bioscience 产品网页
文章摘录数: 8
参考文献
Betancur P, Abraham B, Yiu Y, Willingham S, Khameneh F, Zarnegar M, et al. A CD47-associated super-enhancer links pro-inflammatory signalling to CD47 upregulation in breast cancer. Nat Commun. 2017;8:14802 pubmed 出版商
Pescatore A, Esposito E, Dráber P, Walczak H, Ursini M. NEMO regulates a cell death switch in TNF signaling by inhibiting recruitment of RIPK3 to the cell death-inducing complex II. Cell Death Dis. 2016;7:e2346 pubmed 出版商
O Sullivan S, Gasparini F, Mir A, Dev K. Fractalkine shedding is mediated by p38 and the ADAM10 protease under pro-inflammatory conditions in human astrocytes. J Neuroinflammation. 2016;13:189 pubmed 出版商
Cataldi M, Shah N, Felt S, Grdzelishvili V. Breaking resistance of pancreatic cancer cells to an attenuated vesicular stomatitis virus through a novel activity of IKK inhibitor TPCA-1. Virology. 2015;485:340-54 pubmed 出版商
Gaddipati S, Lu Q, Kasetti R, Miller M, Lu Q, Trent J, et al. IKK2 inhibition using TPCA-1-loaded PLGA microparticles attenuates laser-induced choroidal neovascularization and macrophage recruitment. PLoS ONE. 2015;10:e0121185 pubmed 出版商
Yi F, Wang H, Chai Q, Wang X, Shen W, Willis M, et al. Regulation of large conductance Ca2+-activated K+ (BK) channel ?1 subunit expression by muscle RING finger protein 1 in diabetic vessels. J Biol Chem. 2014;289:10853-64 pubmed 出版商
Lu H, Lu Q, Gaddipati S, Kasetti R, Wang W, Pasparakis M, et al. IKK2 inhibition attenuates laser-induced choroidal neovascularization. PLoS ONE. 2014;9:e87530 pubmed 出版商
Rauert H, Stühmer T, Bargou R, Wajant H, Siegmund D. TNFR1 and TNFR2 regulate the extrinsic apoptotic pathway in myeloma cells by multiple mechanisms. Cell Death Dis. 2011;2:e194 pubmed 出版商
产品信息
品牌 :
Tocris, a Bio-Techne Brand
catalog number base :
2559
SKU号 :
2559/10
产品名称 :
TPCA-1
描述 :
Potent, selective inhibitor of IKK
靶标 :
IkB Kinase Inhibitors
类别 :
Small Molecules
单位尺寸 :
10毫克
纯度 :
97%
观察到的分子量 :
279.29
网址印刷 :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
功能细节 :
TPCA-1 is a potent, selective inhibitor of I B kinase (IKK) (IC50 = 17.9 nM) that displays 22-fold selectivity over IKK and 550-fold selectivity over other kinases and enzymes. Inhibits production of pro-inflammatory cytokines in vitro and in vivo and inhibits NF- B nuclear localization. Reduces the severity and onset of collagen-induced arthritis; anti-inflammatory.
extended description :
Potent, selective inhibitor of IKK
化学品名文本 :
2-[(Aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide
配方 :
C 12 H 10 FN 3 O 2秒
配方文本 :
C12H10FN3O2S
cas num :
507475-17-4
美元 :
323美元
产品细节 :
Potent, selective inhibitor of IKK
储存 :
存放在-20°C
更多信息或购买 :
Tocris Bioscience 产品网页
公司信息
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
公司总部: 英国