产品简要
公司名称 :
Tocris Bioscience
产品类型 :
化学品
产品名称 :
SB 218078
目录 :
2560/1
规格 :
1 mg (also 10 mg)
价格 :
176美元
更多信息或购买 :
Tocris Bioscience 产品网页
文章摘录数: 7
参考文献
Lee Y, Muddaluru V, Anwar S, Wilson J, Campos A. A screen of kinase inhibitors reveals a potential role of Chk1 in regulating Hydra head regeneration and maintenance. Int J Dev Biol. 2021;65:523-536 pubmed 出版商
Colin D, Hain K, Allan L, Clarke P. Cellular responses to a prolonged delay in mitosis are determined by a DNA damage response controlled by Bcl-2 family proteins. Open Biol. 2015;5:140156 pubmed 出版商
Shirazi Fard S, All Ericsson C, Hallböök F. The heterogenic final cell cycle of chicken retinal Lim1 horizontal cells is not regulated by the DNA damage response pathway. Cell Cycle. 2014;13:408-17 pubmed 出版商
Ward S, Kim H, Komurov K, Mendiratta S, Tsai P, Schmolke M, et al. Host modulators of H1N1 cytopathogenicity. PLoS ONE. 2012;7:e39284 pubmed 出版商
Luo Y, Lou S, Deng X, Liu Z, Li Y, Kleiboeker S, et al. Parvovirus B19 infection of human primary erythroid progenitor cells triggers ATR-Chk1 signaling, which promotes B19 virus replication. J Virol. 2011;85:8046-55 pubmed 出版商
Persico A, Cervigni R, Barretta M, Corda D, Colanzi A. Golgi partitioning controls mitotic entry through Aurora-A kinase. Mol Biol Cell. 2010;21:3708-21 pubmed 出版商
Azorsa D, Gonzales I, Basu G, Choudhary A, Arora S, Bisanz K, et al. Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer. J Transl Med. 2009;7:43 pubmed 出版商
图像
图像 1 :
Tocris Bioscience 2560/1 图像 1
Cat.No. 2560 - SB 218078 C24H15N3O3 CAS No. 135897-06-2
产品信息
品牌 :
Tocris, a Bio-Techne Brand
catalog number base :
2560
SKU号 :
2560/1
产品名称 :
SB 218078
描述 :
Chk1 inhibitor
靶标 :
Checkpoint Kinase Inhibitors
类别 :
Small Molecules
单位尺寸 :
1 mg (also 10 mg)
纯度 :
98%
观察到的分子量 :
393.39
网址印刷 :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
功能细节 :
SB 218078 is an inhibitor of checkpoint kinase 1 (Chk1) that displays selectivity over other protein kinases (IC50 values are 15, 250 and 1000 nM for Chk1, cdc2 and PKC respectively). Abrogates G2 cell cycle arrest caused by -irradiation and topoisomerase I inhibition. Potentiates cytotoxicity of DNA-damaging drugs, enhancing the efficacy of some chemotherapeutics.
extended description :
Chk1 inhibitor
化学品名文本 :
9,10,11,12-Tetrahydro- 9,12-epoxy-1H-diindolo[1,2,3-fg:3 ,2 ,1 -kl]pyrrolo[3,4-i][1,6]benzodiazocine-1,3(2H)-dione
配方 :
C 24 H 15 N 3 O 3
配方文本 :
C24H15N3O3
cas num :
135897-06-2
美元 :
176美元
产品细节 :
Chk1 inhibitor
储存 :
存放在RT
更多信息或购买 :
Tocris Bioscience 产品网页
公司信息
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
公司总部: 英国