产品简要
公司名称 :
Tocris Bioscience
产品类型 :
化学品
产品名称 :
NSC 87877
目录 :
2613/50
规格 :
50毫克
价格 :
202美元
更多信息或购买 :
Tocris Bioscience 产品网页
文章摘录数: 8
参考文献
Zhang B, Lu W. Src homology 2 domain-containing phosphotyrosine phosphatase 2 (Shp2) controls surface GluA1 protein in synaptic homeostasis. J Biol Chem. 2017;292:15481-15488 pubmed 出版商
Kim A, Ulirsch J, Wilmes S, Unal E, Moraga I, Karakukcu M, et al. Functional Selectivity in Cytokine Signaling Revealed Through a Pathogenic EPO Mutation. Cell. 2017;168:1053-1064.e15 pubmed 出版商
Zhang B, Du Y, Lu W, Yan X, Yang Q, Yang W, et al. Increased Activity of Src Homology 2 Domain Containing Phosphotyrosine Phosphatase 2 (Shp2) Regulates Activity-dependent AMPA Receptor Trafficking. J Biol Chem. 2016;291:18856-66 pubmed 出版商
Taylor A, Harker J, Chanthong K, Stevenson P, Zuniga E, Rudd C. Glycogen Synthase Kinase 3 Inactivation Drives T-bet-Mediated Downregulation of Co-receptor PD-1 to Enhance CD8(+) Cytolytic T Cell Responses. Immunity. 2016;44:274-86 pubmed 出版商
Pinzon Guzman C, Xing T, Zhang S, Barnstable C. Regulation of rod photoreceptor differentiation by STAT3 is controlled by a tyrosine phosphatase. J Mol Neurosci. 2015;55:152-159 pubmed 出版商
Quintanar Audelo M, Yusoff P, Sinniah S, Chandramouli S, Guy G. Sprouty-related Ena/vasodilator-stimulated phosphoprotein homology 1-domain-containing protein (SPRED1), a tyrosine-protein phosphatase non-receptor type 11 (SHP2) substrate in the Ras/extracellular signal-regulated kinase (ERK) pathway. J Biol Chem. 2011;286:23102-12 pubmed 出版商
Abeyweera T, Merino E, Huse M. Inhibitory signaling blocks activating receptor clustering and induces cytoskeletal retraction in natural killer cells. J Cell Biol. 2011;192:675-90 pubmed 出版商
Fragale A, Stellacci E, Ilari R, Remoli A, Lanciotti A, Perrotti E, et al. Critical role of IRF-8 in negative regulation of TLR3 expression by Src homology 2 domain-containing protein tyrosine phosphatase-2 activity in human myeloid dendritic cells. J Immunol. 2011;186:1951-62 pubmed 出版商
产品信息
品牌 :
Tocris
MasterCode :
2613
SKU号 :
2613/50
产品名称 :
NSC 87877
靶标 :
Protein Tyrosine Phosphatase Inhibitors
类别 :
Small Molecules
单位尺寸 :
50毫克
纯度 :
98%
观察到的分子量 :
459.45
网址印刷 :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
功能细节 :
NSC 87877 is a potent inhibitor of shp2 and shp1 protein tyrosine phosphatases (PTP) (IC50 values are 0.318, 0.355, 1.691, 7.745, 65.617, 84.473 and 150.930 u M for shp2, shp1, PTP1B, HePTP, DEP1, CD45 and LAR respectively). Inhibits EGF-induced Erk1/2 activation in HEK293 cells and significantly reduces MDA-MB-468 cell viability/proliferation.
extended description :
Potent inhibitor of shp2 and shp1 PTP
化学品名文本 :
8-Hydroxy-7-[(6-sulfo-2-naphthyl)azo]-5-quinolinesulfonic acid
配方 :
C 19 H 13 N 3 O 7秒2
配方文本 :
C19H13N3O7S2
cas num :
56990-57-9
美元 :
202美元
产品细节 :
Potent inhibitor of shp2 and shp1 PTP
储存 :
存放在+4°C
更多信息或购买 :
Tocris Bioscience 产品网页
公司信息
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
公司总部: 英国