产品简要
公司名称 :
Tocris Bioscience
产品类型 :
化学品
产品名称 :
L-685, 458
目录 :
2627/1
规格 :
1毫克
价格 :
371美元
更多信息或购买 :
Tocris Bioscience 产品网页
文章摘录数: 9
参考文献
Mentrup T, Stumpff Niggemann A, Leinung N, Schlosser C, Schubert K, Wehner R, et al. Phagosomal signalling of the C-type lectin receptor Dectin-1 is terminated by intramembrane proteolysis. Nat Commun. 2022;13:1880 pubmed 出版商
Kaylan K, Berg I, Biehl M, Brougham Cook A, Jain I, Jamil S, et al. Spatial patterning of liver progenitor cell differentiation mediated by cellular contractility and Notch signaling. elife. 2018;7: pubmed 出版商
Liu C, Zhang C, Zhou Y, Wong W, Lee L, Ong W, et al. APP upregulation contributes to retinal ganglion cell degeneration via JNK3. Cell Death Differ. 2018;25:661-676 pubmed 出版商
Chai Q, Jovasevic V, Malikov V, Sabo Y, MORHAM S, Walsh D, et al. HIV-1 counteracts an innate restriction by amyloid precursor protein resulting in neurodegeneration. Nat Commun. 2017;8:1522 pubmed 出版商
Ran Y, Ladd G, Ceballos Diaz C, Jung J, Greenbaum D, Felsenstein K, et al. Differential Inhibition of Signal Peptide Peptidase Family Members by Established γ-Secretase Inhibitors. PLoS ONE. 2015;10:e0128619 pubmed 出版商
Greife A, Jankowiak S, Steinbring J, Nikpour P, Niegisch G, Hoffmann M, et al. Canonical Notch signalling is inactive in urothelial carcinoma. BMC Cancer. 2014;14:628 pubmed 出版商
Origlia N, Criscuolo C, Arancio O, Yan S, Domenici L. RAGE inhibition in microglia prevents ischemia-dependent synaptic dysfunction in an amyloid-enriched environment. J Neurosci. 2014;34:8749-60 pubmed 出版商
Ran Y, Cruz P, Ladd T, Fauq A, Jung J, Matthews J, et al. ?-Secretase processing and effects of ?-secretase inhibitors and modulators on long A? peptides in cells. J Biol Chem. 2014;289:3276-87 pubmed 出版商
Williams C, Segarra M, Sierra M, Sainson R, Tosato G, Harris A. Regulation of CXCR4 by the Notch ligand delta-like 4 in endothelial cells. Cancer Res. 2008;68:1889-95 pubmed 出版商
产品信息
品牌 :
Tocris
MasterCode :
2627
SKU号 :
2627/1
产品名称 :
L-685, 458
靶标 :
Secretase Inhibitors
类别 :
Small Molecules
单位尺寸 :
1毫克
纯度 :
97%
观察到的分子量 :
672.85
网址印刷 :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
功能细节 :
L-685,458 is a potent and selective -secretase inhibitor (IC50 = 17 nM) that displays 50-fold selectivity over a range of aspartyl, serine and cysteine proteases. L-685,458 binds with high affinity to the related aspartyl protease, signal peptide peptidase (SPP; KD = 5.1 nM), and inhibits SPP expressed in HEK293 cells (IC50 = 10 M). L-685,458 exhibits equal potency for inhibition of A 40 and A 42 peptides (IC50 values are 48 and 67 nM respectively in human neuroblastoma cells). It also regulates CXCR4 and VEGFR2 expression through inhibition of Notch signaling in vitro .
extended description :
Potent and selective -secretase inhibitor
化学品名文本 :
(5S)-(tert-Butoxycarbonylamino)-6-phenyl-(4R)-hydroxy-(2R)-benzylhexanoyl)-L-leucy-L-phenylalaninamide
配方 :
C 39 H 52 N 4 O 6
配方文本 :
C39H52N4O6
cas num :
292632-98-5
美元 :
371美元
产品细节 :
Potent and selective -secretase inhibitor
别名 :
L 458, -Secretase Inhibitor X
储存 :
存放在-20°C
更多信息或购买 :
Tocris Bioscience 产品网页
公司信息
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
公司总部: 英国