产品简要
公司名称 :
Tocris Bioscience
产品类型 :
化学品
产品名称 :
Marimastat
目录 :
2631/1
规格 :
1 mg (also 10 mg)
价格 :
189美元
更多信息或购买 :
文章摘录数: 22
参考文献
Wisdom K, Adebowale K, Chang J, Lee J, Nam S, Desai R, et al. Matrix mechanical plasticity regulates cancer cell migration through confining microenvironments. Nat Commun. 2018;9:4144 pubmed 出版商
Megia Fernandez A, Mills B, Michels C, Chankeshwara S, Krstajic N, Haslett C, et al. Bimodal fluorogenic sensing of matrix proteolytic signatures in lung cancer. Org Biomol Chem. 2018;16:8056-8063 pubmed 出版商
Bezenah J, Kong Y, Putnam A. Evaluating the potential of endothelial cells derived from human induced pluripotent stem cells to form microvascular networks in 3D cultures. Sci Rep. 2018;8:2671 pubmed 出版商
Pitt J, Wilcox K, Tortelli V, Diniz L, Oliveira M, Dobbins C, et al. Neuroprotective astrocyte-derived insulin/insulin-like growth factor 1 stimulates endocytic processing and extracellular release of neuron-bound A? oligomers. Mol Biol Cell. 2017;28:2623-2636 pubmed 出版商
Rosner M, Pham H, Moriggl R, Hengstschlager M. Human stem cells alter the invasive properties of somatic cells via paracrine activation of mTORC1. Nat Commun. 2017;8:595 pubmed 出版商
Trappmann B, Baker B, Polacheck W, Choi C, Burdick J, Chen C. Matrix degradability controls multicellularity of 3D cell migration. Nat Commun. 2017;8:371 pubmed 出版商
Lahey K, Ronaghan N, Shang J, Dion S, Desilets A, Leduc R, et al. Signaling pathways induced by serine proteases to increase intestinal epithelial barrier function. PLoS ONE. 2017;12:e0180259 pubmed 出版商
Madoux F, Dreymüller D, Pettiloud J, Santos R, Becker Pauly C, Ludwig A, et al. Discovery of an enzyme and substrate selective inhibitor of ADAM10 using an exosite-binding glycosylated substrate. Sci Rep. 2016;6:11 pubmed 出版商
Nicolaou A, Zhao Z, Northoff B, Sass K, Herbst A, Kohlmaier A, et al. Adam17 Deficiency Promotes Atherosclerosis by Enhanced TNFR2 Signaling in Mice. Arterioscler Thromb Vasc Biol. 2017;37:247-257 pubmed 出版商
Ji J, Jia S, Jia Y, Ji K, Hargest R, Jiang W. WISP-2 in human gastric cancer and its potential metastatic suppressor role in gastric cancer cells mediated by JNK and PLC-γ pathways. Br J Cancer. 2015;113:921-33 pubmed 出版商
Knapinska A, Dreymüller D, Ludwig A, Smith L, Golubkov V, Sohail A, et al. SAR Studies of Exosite-Binding Substrate-Selective Inhibitors of A Disintegrin And Metalloprotease 17 (ADAM17) and Application as Selective in Vitro Probes. J Med Chem. 2015;58:5808-24 pubmed 出版商
Zariffard M, Anastos K, French A, Munyazesa E, Cohen M, Landay A, et al. Cleavage/alteration of interleukin-8 by matrix metalloproteinase-9 in the female lower genital tract. PLoS ONE. 2015;10:e0116911 pubmed 出版商
Lee C, Zhan Q, Lezcano C, Frank M, Huang J, Larson A, et al. Nestin depletion induces melanoma matrix metalloproteinases and invasion. Lab Invest. 2014;94:1382-95 pubmed 出版商
Li M, Shao J, Meng Y, Mei J, Wang Y, Li H, et al. NME1 suppression promotes growth, adhesion and implantation of endometrial stromal cells via Akt and MAPK/Erk1/2 signal pathways in the endometriotic milieu. Hum Reprod. 2013;28:2822-31 pubmed 出版商
Guo Z, Jin X, Jia H. Inhibition of ADAM-17 more effectively down-regulates the Notch pathway than that of ?-secretase in renal carcinoma. J Exp Clin Cancer Res. 2013;32:26 pubmed 出版商
Brafman D, Phung C, Kumar N, Willert K. Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions. Cell Death Differ. 2013;20:369-81 pubmed 出版商
Yurtsever Z, Sala Rabanal M, Randolph D, Scheaffer S, Roswit W, Alevy Y, et al. Self-cleavage of human CLCA1 protein by a novel internal metalloprotease domain controls calcium-activated chloride channel activation. J Biol Chem. 2012;287:42138-49 pubmed 出版商
Mezil L, Berruyer Pouyet C, Cabaud O, Josselin E, Combes S, Brunel J, et al. Tumor selective cytotoxic action of a thiomorpholin hydroxamate inhibitor (TMI-1) in breast cancer. PLoS ONE. 2012;7:e43409 pubmed 出版商
Prendergast A, Linbo T, Swarts T, Ungos J, McGraw H, Krispin S, et al. The metalloproteinase inhibitor Reck is essential for zebrafish DRG development. Development. 2012;139:1141-52 pubmed 出版商
Kachgal S, Carrion B, Janson I, Putnam A. Bone marrow stromal cells stimulate an angiogenic program that requires endothelial MT1-MMP. J Cell Physiol. 2012;227:3546-55 pubmed 出版商
Kachgal S, Putnam A. Mesenchymal stem cells from adipose and bone marrow promote angiogenesis via distinct cytokine and protease expression mechanisms. Angiogenesis. 2011;14:47-59 pubmed 出版商
Ghajar C, Kachgal S, Kniazeva E, Mori H, Costes S, George S, et al. Mesenchymal cells stimulate capillary morphogenesis via distinct proteolytic mechanisms. Exp Cell Res. 2010;316:813-25 pubmed 出版商
产品信息
品牌 :
Tocris
MasterCode :
2631
SKU号 :
2631/1
产品名称 :
Marimastat
靶标 :
Synthetic Metalloprotease Inhibitors
类别 :
Small Molecules
单位尺寸 :
1 mg (also 10 mg)
纯度 :
99%
观察到的分子量 :
331.41
网址印刷 :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
功能细节 :
Marimastat is a broad spectrum inhibitor of MMPs (IC50 values are 3, 5, 6, 9 and 13 nM for MMP-9, MMP-1, MMP-2, MMP-14 and MMP-7 respectively). Inhibits peritoneal dissemination of human gastric cancer cells in vivo through inhibition of tumor angiogenesis.
extended description :
Broad spectrum MMP inhibitor
化学品名文本 :
(2S,3R)-N4-[(1S)-2,2-Dimethyl-1-[(methylamino)carbonyl]propyl]-N1,2-dihydroxy-3-(2-methylpropyl)butanediamide
配方 :
C 15 H 29 N 3 O 5
配方文本 :
C15H29N3O5
cas num :
154039-60-8
美元 :
189美元
产品细节 :
Broad spectrum MMP inhibitor
别名 :
BB 2516, Marimistat
储存 :
存放在-20°C
更多信息或购买 :
公司信息
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
公司总部: 英国