产品简要
公司名称 :
Tocris Bioscience
产品类型 :
化学品
产品名称 :
DAPT
目录 :
2634/10
规格 :
10 mg (also 50 mg)
价格 :
293美元
更多信息或购买 :
文章摘录数: 53
参考文献
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Raven F, Ward J, Zoltowska K, Wan Y, Bylykbashi E, Miller S, et al. Soluble Gamma-secretase Modulators Attenuate Alzheimer's ?-amyloid Pathology and Induce Conformational Changes in Presenilin 1. EBioMedicine. 2017;24:93-101 pubmed 出版商
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Calton C, Bronnimann M, Manson A, Li S, Chapman J, Suarez Berumen M, et al. Translocation of the papillomavirus L2/vDNA complex across the limiting membrane requires the onset of mitosis. PLoS Pathog. 2017;13:e1006200 pubmed 出版商
Schumacher M, Hedl M, Abraham C, Bernard J, Lozano P, Hsieh J, et al. ErbB4 signaling stimulates pro-inflammatory macrophage apoptosis and limits colonic inflammation. Cell Death Dis. 2017;8:e2622 pubmed 出版商
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Guest R, Boulter L, Dwyer B, Kendall T, Man T, Minnis Lyons S, et al. Notch3 drives development and progression of cholangiocarcinoma. Proc Natl Acad Sci U S A. 2016;113:12250-12255 pubmed
Wang L, Egli D, Leibel R. Efficient Generation of Hypothalamic Neurons from Human Pluripotent Stem Cells. Curr Protoc Hum Genet. 2016;90:21.5.1-21.5.14 pubmed 出版商
Campbell D, Chrysostomou E, Doetzlhofer A. Canonical Notch signaling plays an instructive role in auditory supporting cell development. Sci Rep. 2016;6:19484 pubmed 出版商
Lu J, Zhong X, Liu H, Hao L, Huang C, Sherafat M, et al. Generation of serotonin neurons from human pluripotent stem cells. Nat Biotechnol. 2016;34:89-94 pubmed 出版商
Onai T, Aramaki T, Inomata H, Hirai T, Kuratani S. On the origin of vertebrate somites. Zoological Lett. 2015;1:33 pubmed 出版商
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Gomez D, O Driscoll M, Sheets T, Hruban R, Oberholzer J, McGarrigle J, et al. Neurogenin 3 Expressing Cells in the Human Exocrine Pancreas Have the Capacity for Endocrine Cell Fate. PLoS ONE. 2015;10:e0133862 pubmed 出版商
Edri R, Yaffe Y, Ziller M, Mutukula N, Volkman R, David E, et al. Analysing human neural stem cell ontogeny by consecutive isolation of Notch active neural progenitors. Nat Commun. 2015;6:6500 pubmed 出版商
Kerr G, Sheldon H, Chaikuad A, Alfano I, von Delft F, Bullock A, et al. A small molecule targeting ALK1 prevents Notch cooperativity and inhibits functional angiogenesis. Angiogenesis. 2015;18:209-17 pubmed 出版商
Gioia U, Di Carlo V, Caramanica P, Toselli C, Cinquino A, Marchioni M, et al. Mir-23a and mir-125b regulate neural stem/progenitor cell proliferation by targeting Musashi1. RNA Biol. 2014;11:1105-12 pubmed 出版商
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Shah M, Zerlin M, Li B, Herzog T, KITAJEWSKI J, Wright J. The role of Notch and gamma-secretase inhibition in an ovarian cancer model. Anticancer Res. 2013;33:801-8 pubmed
Fraser G, Bloomquist R, Streelman J. Common developmental pathways link tooth shape to regeneration. Dev Biol. 2013;377:399-414 pubmed 出版商
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Hsieh E, Lo D. Jagged1 and Notch1 help edit M cell patterning in Peyer's patch follicle epithelium. Dev Comp Immunol. 2012;37:306-12 pubmed 出版商
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El Bejjani R, Hammarlund M. Notch signaling inhibits axon regeneration. Neuron. 2012;73:268-78 pubmed 出版商
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Berndt J, Aoyagi A, Yang P, Anastas J, Tang L, Moon R. Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/?-catenin signaling. J Cell Biol. 2011;194:737-50 pubmed 出版商
Kolegraff K, Nava P, Laur O, Parkos C, Nusrat A. Characterization of full-length and proteolytic cleavage fragments of desmoglein-2 in native human colon and colonic epithelial cell lines. Cell Adh Migr. 2011;5:306-14 pubmed
Kim S, Fraser P, Westaway D, St George Hyslop P, Ehrlich M, Gandy S. Group II metabotropic glutamate receptor stimulation triggers production and release of Alzheimer's amyloid(beta)42 from isolated intact nerve terminals. J Neurosci. 2010;30:3870-5 pubmed 出版商
产品信息
品牌 :
Tocris
MasterCode :
2634
SKU号 :
2634/10
产品名称 :
DAPT
靶标 :
Secretase Inhibitors
类别 :
Small Molecules
单位尺寸 :
10 mg (also 50 mg)
纯度 :
99%
观察到的分子量 :
432.46
网址印刷 :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
功能细节 :
DAPT is a -secretase inhibitor. DAPT reduces A 40 and A 42 levels in human primary neuronal cultures (IC50 values are 115 and 200 nM for total A and A 42 respectively) and in brain extract, cerebrospinal fluid and plasma in vivo . DAPT has no effect on APP and APP levels. DAPT blocks Notch signaling in hybrid human-mouse fetal thymus organ culture (FTOC) and causes ESCs to commit to neuronal differentiation. DAPT can be used in a small molecule cocktail to derive cortical neurons from hPSCs and to maintain hepatocytes in culture. DAPT also promotes the formation of cone photoreceptors in retinal organoids. . For more information about how DAPT may be used, see our protocols: Accelerated Induction of Cortical Neurons from hiPSCs, Human iPSC-derived Myoblasts, Generating Midbrain Dopaminergic Neurons from hPSCs . . DAPT synthesized to Ancillary Material Grade also available.
extended description :
Gamma -secretase inhibitor; induces neuronal differentiation; blocks Notch signaling
化学品名文本 :
(2S)-N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenyl]glycine 1,1-dimethylethyl ester
配方 :
C 23 H 26 F 2 N 2 O 4
配方文本 :
C23H26F2N2O4
cas num :
208255-80-5
美元 :
293美元
产品细节 :
Gamma -secretase inhibitor; induces neuronal differentiation; blocks Notch signaling
储存 :
存放在+4°C
更多信息或购买 :
公司信息
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
公司总部: 英国