产品简要
公司名称 :
Tocris Bioscience
产品类型 :
化学品
产品名称 :
Pifithrin-mu
目录 :
2653/10
规格 :
10 mg (also 50 mg)
价格 :
119美元
更多信息或购买 :
Tocris Bioscience 产品网页
文章摘录数: 6
参考文献
Li H, Zhang J, Niswander L. Zinc deficiency causes neural tube defects through attenuation of p53 ubiquitylation. Development. 2018;145: pubmed 出版商
Nemade H, Chaudhari U, Acharya A, Hescheler J, Hengstler J, Papadopoulos S, et al. Cell death mechanisms of the anti-cancer drug etoposide on human cardiomyocytes isolated from pluripotent stem cells. Arch Toxicol. 2018;92:1507-1524 pubmed 出版商
Blatzer M, Blum G, Jukic E, Posch W, Gruber P, Nagl M, et al. Blocking Hsp70 enhances the efficiency of amphotericin B treatment against resistant Aspergillus terreus strains. Antimicrob Agents Chemother. 2015;59:3778-88 pubmed 出版商
Xia H, Zhang W, Li Y, Guo N, Yu C. EZH2 silencing with RNA interference induces G2/M arrest in human lung cancer cells in vitro. Biomed Res Int. 2014;2014:348728 pubmed 出版商
Wang H, Wu C, Cheng T, Kuo C, Tsai Y, Chiang S, et al. Active Constituents from Liriope platyphylla Root against Cancer Growth In Vitro. Evid Based Complement Alternat Med. 2013;2013:857929 pubmed 出版商
Kojima K, Burks J, Arts J, Andreeff M. The novel tryptamine derivative JNJ-26854165 induces wild-type p53- and E2F1-mediated apoptosis in acute myeloid and lymphoid leukemias. Mol Cancer Ther. 2010;9:2545-57 pubmed 出版商
产品信息
品牌 :
Tocris
MasterCode :
2653
SKU号 :
2653/10
产品名称 :
Pifithrin-mu
靶标 :
p53 Inhibitors
类别 :
Small Molecules
单位尺寸 :
10 mg (also 50 mg)
纯度 :
99%
观察到的分子量 :
181.21
网址印刷 :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
功能细节 :
Pifithrin- inhibits p53 binding to mitochondria by reducing its affinity for antiapoptotic proteins Bcl-2 and Bcl-XL. Displays no effect on the transactivational or cell cycle checkpoint control function of p53. Potentially increases reprogramming efficiency of human somatic cells to induced pluripotent stem cells (iPSCs) by silencing p53. Pifithrin- reduces cell death induced by -radiation in vitro and protects mice from doses of radiation that cause lethal hematopoietic syndrome. Selectively inhibits heat shock protein 70 (HSP70) activity.
extended description :
Inhibitor of p53-mitochondrial binding
化学品名文本 :
2-Phenylethynesulfonamide
配方 :
C 8 H 7 NO 2秒
配方文本 :
C8H7NO2S
cas num :
64984-31-2
美元 :
119美元
产品细节 :
Inhibitor of p53-mitochondrial binding
别名 :
NSC 303580
储存 :
存放在+4°C
更多信息或购买 :
Tocris Bioscience 产品网页
公司信息
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
公司总部: 英国