产品简要
公司名称 :
Tocris Bioscience
产品类型 :
化学品
产品名称 :
LY 364947
目录 :
2718
规格 :
1 mg (also 10 mg)
价格 :
103美元
更多信息或购买 :
Tocris Bioscience 产品网页
文章摘录数: 11
参考文献
Al Ameri W, Ahmed I, Al Dasim F, Ali Mohamoud Y, Al Azwani I, Malek J, et al. Cell Type-Specific TGF-β Mediated EMT in 3D and 2D Models and Its Reversal by TGF-β Receptor Kinase Inhibitor in Ovarian Cancer Cell Lines. Int J Mol Sci. 2019;20: pubmed 出版商
Wang F, Wang X, Shapiro L, Cotrina M, Liu W, Wang E, et al. NKCC1 up-regulation contributes to early post-traumatic seizures and increased post-traumatic seizure susceptibility. Brain Struct Funct. 2017;222:1543-1556 pubmed 出版商
Yumoto K, Eber M, Wang J, Cackowski F, Decker A, Lee E, et al. Axl is required for TGF-β2-induced dormancy of prostate cancer cells in the bone marrow. Sci Rep. 2016;6:36520 pubmed 出版商
Oruqaj G, Karnati S, Vijayan V, Kotarkonda L, Boateng E, Zhang W, et al. Compromised peroxisomes in idiopathic pulmonary fibrosis, a vicious cycle inducing a higher fibrotic response via TGF-β signaling. Proc Natl Acad Sci U S A. 2015;112:E2048-57 pubmed 出版商
Oshimori N, Oristian D, Fuchs E. TGF-β promotes heterogeneity and drug resistance in squamous cell carcinoma. Cell. 2015;160:963-976 pubmed 出版商
Jajosky A, Coad J, Vos J, Martin K, Senft J, Wenger S, et al. RepSox slows decay of CD34+ acute myeloid leukemia cells and decreases T cell immunoglobulin mucin-3 expression. Stem Cells Transl Med. 2014;3:836-48 pubmed 出版商
Sethi A, Wordinger R, Clark A. Gremlin utilizes canonical and non-canonical TGF? signaling to induce lysyl oxidase (LOX) genes in human trabecular meshwork cells. Exp Eye Res. 2013;113:117-27 pubmed 出版商
Oerlecke I, Bauer E, Dittmer A, Leyh B, Dittmer J. Cyclic AMP enhances TGF? responses of breast cancer cells by upregulating TGF? receptor I expression. PLoS ONE. 2013;8:e54261 pubmed 出版商
Hough C, Radu M, Doré J. Tgf-beta induced Erk phosphorylation of smad linker region regulates smad signaling. PLoS ONE. 2012;7:e42513 pubmed 出版商
Sethi A, Jain A, Zode G, Wordinger R, Clark A. Role of TGFbeta/Smad signaling in gremlin induction of human trabecular meshwork extracellular matrix proteins. Invest Ophthalmol Vis Sci. 2011;52:5251-9 pubmed 出版商
Sethi A, Mao W, Wordinger R, Clark A. Transforming growth factor-beta induces extracellular matrix protein cross-linking lysyl oxidase (LOX) genes in human trabecular meshwork cells. Invest Ophthalmol Vis Sci. 2011;52:5240-50 pubmed 出版商
产品信息
品牌 :
Tocris
master code :
2718
SKU号 :
2718/1
产品名称 :
LY 364947
描述 :
Selective inhibitor of TGF- RI
靶标 :
TGF-beta Receptor Inhibitors
类别 :
Small Molecules
单位尺寸 :
1 mg (also 10 mg)
纯度 :
99%
观察到的分子量 :
272.31
网址印刷 :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
功能细节 :
Selective inhibitor of TGF- type-I receptor (TGF- RI, TGFR-I, T R-I, ALK-5) (IC50 values are 59, 400 and 1400 nM for TGR- RI, TGF- RII and MLK-7K respectively). Inhibits TGF- -dependent luciferase production in mink lung cells (p3TP lux) and growth in mouse fibroblasts (NIH 3T3) (IC50 values are 47 and 89 nM respectively). Suppresses invasion of MDA-MB-231 breast cancer cells in a matrigel invasion assay.
catalog number base :
2718
extended description :
Selective inhibitor of TGF- RI
化学品名文本 :
4-[3-(2-Pyridinyl)-1H-pyrazol-4-yl]-quinoline
配方 :
C 17 H 12 N 4
配方文本 :
C17H12N4
cas num :
396129-53-6
美元 :
103美元
别名 :
HTS 466284
储存 :
存放在RT
更多信息或购买 :
Tocris Bioscience 产品网页
公司信息
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
公司总部: 英国