产品简要
公司名称 :
Tocris Bioscience
产品类型 :
化学品
产品名称 :
SB 265610
目录 :
2724/1
规格 :
1 mg (also 10 mg, 50 mg)
价格 :
129美元
更多信息或购买 :
文章摘录数: 8
参考文献
He W, Holtkamp S, Hergenhan S, Kraus K, De Juan A, Weber J, et al. Circadian Expression of Migratory Factors Establishes Lineage-Specific Signatures that Guide the Homing of Leukocyte Subsets to Tissues. Immunity. 2018;49:1175-1190.e7 pubmed 出版商
Jung J, Kang K, Kim J, Hong S, Park Y, Kim B. CXCR2 Inhibition in Human Pluripotent Stem Cells Induces Predominant Differentiation to Mesoderm and Endoderm Through Repression of mTOR, ?-Catenin, and hTERT Activities. Stem Cells Dev. 2016;25:1006-19 pubmed 出版商
Esser von Bieren J, Volpe B, Sutherland D, Bürgi J, Verbeek J, Marsland B, et al. Immune antibodies and helminth products drive CXCR2-dependent macrophage-myofibroblast crosstalk to promote intestinal repair. PLoS Pathog. 2015;11:e1004778 pubmed 出版商
Ha H, Bensman T, Ho H, Beringer P, Neamati N. A novel phenylcyclohex-1-enecarbothioamide derivative inhibits CXCL8-mediated chemotaxis through selective regulation of CXCR2-mediated signalling. Br J Pharmacol. 2014;171:1551-65 pubmed 出版商
Toh B, Wang X, Keeble J, Sim W, Khoo K, Wong W, et al. Mesenchymal transition and dissemination of cancer cells is driven by myeloid-derived suppressor cells infiltrating the primary tumor. PLoS Biol. 2011;9:e1001162 pubmed 出版商
Halpern J, Kilbarger A, Lynch C. Mesenchymal stem cells promote mammary cancer cell migration in vitro via the CXCR2 receptor. Cancer Lett. 2011;308:91-9 pubmed 出版商
Burton V, Ciuclan L, Holmes A, Rodman D, Walker C, Budd D. Bone morphogenetic protein receptor II regulates pulmonary artery endothelial cell barrier function. Blood. 2011;117:333-41 pubmed 出版商
Lavoie Lamoureux A, Moran K, Beauchamp G, Mauel S, Steinbach F, Lefebvre Lavoie J, et al. IL-4 activates equine neutrophils and induces a mixed inflammatory cytokine expression profile with enhanced neutrophil chemotactic mediator release ex vivo. Am J Physiol Lung Cell Mol Physiol. 2010;299:L472-82 pubmed 出版商
产品信息
品牌 :
Tocris
MasterCode :
2724
SKU号 :
2724/1
产品名称 :
SB 265610
靶标 :
Chemokine Receptor Antagonists
类别 :
Small Molecules
单位尺寸 :
1 mg (also 10 mg, 50 mg)
纯度 :
98%
观察到的分子量 :
357.16
网址印刷 :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
功能细节 :
SB 265610 is a potent CXCR2 antagonist that inhibits CINC-1-mediated but not C5a-mediated Ca2+ mobilization (IC50 values are 3.4 and 6800 nM respectively). Inhibits CINC-induced chemotaxis and attenuates neutrophil accumulation in inflammatory lung injury in vivo .
extended description :
Potent CXCR2 antagonist
化学品名文本 :
N-(2-Bromophenyl)-N -(7-cyano-1H-benzotriazol-4-yl)urea
配方 :
C 14 H 9 BrN 6 O
配方文本 :
C14H9BrN6O
cas num :
211096-49-0
美元 :
129美元
产品细节 :
Potent CXCR2 antagonist
储存 :
存放在RT
更多信息或购买 :
公司信息
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
公司总部: 英国