产品简要
公司名称 :
Tocris Bioscience
产品类型 :
化学品
产品名称 :
SB 225002
目录 :
2725/10
规格 :
10 mg (also 50 mg)
价格 :
275美元
更多信息或购买 :
Tocris Bioscience 产品网页
文章摘录数: 12
参考文献
Chen J, Lai Y, Chu P, Chan S, Wang L, Hung W. Cancer-Derived VEGF-C Increases Chemokine Production in Lymphatic Endothelial Cells to Promote CXCR2-Dependent Cancer Invasion and MDSC Recruitment. Cancers (Basel). 2019;11: pubmed 出版商
Karim H, Kim S, Lauderdale K, Lapato A, Atkinson K, Yasui N, et al. Analogues of ERβ ligand chloroindazole exert immunomodulatory and remyelinating effects in a mouse model of multiple sclerosis. Sci Rep. 2019;9:503 pubmed 出版商
Saika F, Matsuzaki S, Kobayashi D, Kiguchi N, Kishioka S. Chemokine CXCL1 is responsible for cocaine-induced reward in mice. Neuropsychopharmacol Rep. 2018;38:145-148 pubmed 出版商
Jung J, Kang K, Kim J, Hong S, Park Y, Kim B. CXCR2 Inhibition in Human Pluripotent Stem Cells Induces Predominant Differentiation to Mesoderm and Endoderm Through Repression of mTOR, ?-Catenin, and hTERT Activities. Stem Cells Dev. 2016;25:1006-19 pubmed 出版商
Devapatla B, Sharma A, Woo S. CXCR2 Inhibition Combined with Sorafenib Improved Antitumor and Antiangiogenic Response in Preclinical Models of Ovarian Cancer. PLoS ONE. 2015;10:e0139237 pubmed 出版商
Grabner B, Schramek D, Mueller K, Moll H, Svinka J, Hoffmann T, et al. Disruption of STAT3 signalling promotes KRAS-induced lung tumorigenesis. Nat Commun. 2015;6:6285 pubmed 出版商
Lourenço S, Teixeira V, Kalber T, José R, Floto R, Janes S. Macrophage migration inhibitory factor-CXCR4 is the dominant chemotactic axis in human mesenchymal stem cell recruitment to tumors. J Immunol. 2015;194:3463-74 pubmed 出版商
Raccosta L, Fontana R, Maggioni D, Lanterna C, Villablanca E, Paniccia A, et al. The oxysterol-CXCR2 axis plays a key role in the recruitment of tumor-promoting neutrophils. J Exp Med. 2013;210:1711-28 pubmed 出版商
Yuen D, Zhang Y, Thai K, Spring C, Chan L, Guo X, et al. Angiogenic dysfunction in bone marrow-derived early outgrowth cells from diabetic animals is attenuated by SIRT1 activation. Stem Cells Transl Med. 2012;1:921-6 pubmed 出版商
Toh B, Wang X, Keeble J, Sim W, Khoo K, Wong W, et al. Mesenchymal transition and dissemination of cancer cells is driven by myeloid-derived suppressor cells infiltrating the primary tumor. PLoS Biol. 2011;9:e1001162 pubmed 出版商
Jang J, Hod E, Spitalnik S, Frenette P. CXCL1 and its receptor, CXCR2, mediate murine sickle cell vaso-occlusion during hemolytic transfusion reactions. J Clin Invest. 2011;121:1397-401 pubmed 出版商
Lavoie Lamoureux A, Moran K, Beauchamp G, Mauel S, Steinbach F, Lefebvre Lavoie J, et al. IL-4 activates equine neutrophils and induces a mixed inflammatory cytokine expression profile with enhanced neutrophil chemotactic mediator release ex vivo. Am J Physiol Lung Cell Mol Physiol. 2010;299:L472-82 pubmed 出版商
产品信息
品牌 :
Tocris
MasterCode :
2725
SKU号 :
2725/10
产品名称 :
SB 225002
靶标 :
Chemokine Receptor Antagonists
类别 :
Small Molecules
单位尺寸 :
10 mg (also 50 mg)
纯度 :
99%
观察到的分子量 :
352.14
网址印刷 :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
功能细节 :
SB 225002 is a potent and selective CXCR2 chemokine receptor antagonist (IC50 = 22 nM) that displays 150-fold selectivity over CXCR1 receptors. Causes inhibition of IL-8 and GRO -mediated calcium mobilization in HL60 cells (IC50 values are 8 and 10 nM respectively). Prevents IL-8-induced neutrophil chemotaxis in vitro and sequestration in vivo . Inhibits HIV replication in lymphocytes and macrophages.
extended description :
Potent and selective CXCR2 antagonist
化学品名文本 :
N-(2-Bromophenyl)-N -(2-hydroxy-4-nitrophenyl)urea
配方 :
C 13 H 10 BrN 3 O 4
配方文本 :
C13H10BrN3O4
cas num :
182498-32-4
美元 :
275美元
产品细节 :
Potent and selective CXCR2 antagonist
储存 :
存放在RT
更多信息或购买 :
Tocris Bioscience 产品网页
公司信息
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
公司总部: 英国