产品简要
公司名称 :
Tocris Bioscience
产品类型 :
化学品
产品名称 :
MTEP hydrochloride
目录 :
2921/10
规格 :
10 mg (also 50 mg)
价格 :
216美元
更多信息或购买 :
文章摘录数: 11
参考文献
Lim D, Mapelli L, Canonico P, Moccia F, Genazzani A. Neuronal Activity-Dependent Activation of Astroglial Calcineurin in Mouse Primary Hippocampal Cultures. Int J Mol Sci. 2018;19: pubmed 出版商
Thomson S, Seo S, Barnes S, Louros S, Muscas M, Dando O, et al. Cell-Type-Specific Translation Profiling Reveals a Novel Strategy for Treating Fragile X Syndrome. Neuron. 2017;95:550-563.e5 pubmed 出版商
Arsenault D, Coulombe K, Zhu A, Gong C, Kil K, Choi J, et al. Loss of Metabotropic Glutamate Receptor 5 Function on Peripheral Benzodiazepine Receptor in Mice Prenatally Exposed to LPS. PLoS ONE. 2015;10:e0142093 pubmed 出版商
Rosa J, Bos R, Sack G, Fortuny C, Agarwal A, Bergles D, et al. Neuron-glia signaling in developing retina mediated by neurotransmitter spillover. elife. 2015;4: pubmed 出版商
Guimaraes I, Carvalho T, Ferguson S, Pereira G, Ribeiro F. The metabotropic glutamate receptor 5 role on motor behavior involves specific neural substrates. Mol Brain. 2015;8:24 pubmed 出版商
Pollard M, Bartolome J, Conn P, Steckler T, Shaban H. Modulation of neuronal microcircuit activities within the medial prefrontal cortex by mGluR5 positive allosteric modulator. J Psychopharmacol. 2014;28:935-46 pubmed 出版商
Reissner K, Gipson C, Tran P, Knackstedt L, Scofield M, Kalivas P. Glutamate transporter GLT-1 mediates N-acetylcysteine inhibition of cocaine reinstatement. Addict Biol. 2015;20:316-23 pubmed 出版商
Jurgens C, Bell K, McQuiston A, Guido W. Optogenetic stimulation of the corticothalamic pathway affects relay cells and GABAergic neurons differently in the mouse visual thalamus. PLoS ONE. 2012;7:e45717 pubmed 出版商
Ren B, Gu X, Zheng Y, Liu C, Wang D, Sun Y, et al. Intrathecal injection of metabotropic glutamate receptor subtype 3 and 5 agonist/antagonist attenuates bone cancer pain by inhibition of spinal astrocyte activation in a mouse model. Anesthesiology. 2012;116:122-32 pubmed 出版商
Sumislawski J, Ramikie T, Patel S. Reversible gating of endocannabinoid plasticity in the amygdala by chronic stress: a potential role for monoacylglycerol lipase inhibition in the prevention of stress-induced behavioral adaptation. Neuropsychopharmacology. 2011;36:2750-61 pubmed 出版商
Tronson N, Guzman Y, Guedea A, Huh K, Gao C, Schwarz M, et al. Metabotropic glutamate receptor 5/Homer interactions underlie stress effects on fear. Biol Psychiatry. 2010;68:1007-15 pubmed 出版商
产品信息
品牌 :
Tocris
MasterCode :
2921
SKU号 :
2921/10
产品名称 :
MTEP hydrochloride
靶标 :
Group I mGluR Antagonists
类别 :
Small Molecules
单位尺寸 :
10 mg (also 50 mg)
纯度 :
99%
观察到的分子量 :
236.72
网址印刷 :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
功能细节 :
MTEP hydrochloride is a potent, selective and non-competitive mGlu5 antagonist (IC50 = 5 nM in Ca2+-flux assay; Ki= 16 nM). Displays anxiolytic activity in vivo and is orally active.
extended description :
Potent and selective mGlu5 antagonist
化学品名文本 :
3-((2-Methyl-1,3-thiazol-4-yl)ethynyl)pyridine hydrochloride
配方 :
C 11 H 8 N 2 secondsHCl
配方文本 :
C11H8N2S.氯化氢
cas num :
1186195-60-7
美元 :
216美元
产品细节 :
Potent and selective mGlu5 antagonist
储存 :
存放在-20°C
更多信息或购买 :
公司信息
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
公司总部: 英国