产品简要
公司名称 :
Tocris Bioscience
产品类型 :
化学品
产品名称 :
A 83-01
目录 :
2939
规格 :
10 mg (also 50 mg)
价格 :
225美元
更多信息或购买 :
文章摘录数: 77
参考文献
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Li Y, Soendergaard C, Bergenheim F, Aronoff D, Milne G, Riis L, et al. COX-2-PGE2 Signaling Impairs Intestinal Epithelial Regeneration and Associates with TNF Inhibitor Responsiveness in Ulcerative Colitis. EBioMedicine. 2018;36:497-507 pubmed 出版商
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Yakoub A, Sadek M. Development and Characterization of Human Cerebral Organoids: An Optimized Protocol. Cell Transplant. 2018;27:393-406 pubmed 出版商
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Kashfi S, Almozyan S, Jinks N, Koo B, Nateri A. Morphological alterations of cultured human colorectal matched tumour and healthy organoids. Oncotarget. 2018;9:10572-10584 pubmed 出版商
Liu P, Chen M, Liu Y, Qi L, Ding S. CRISPR-Based Chromatin Remodeling of the Endogenous Oct4 or Sox2 Locus Enables Reprogramming to Pluripotency. Cell Stem Cell. 2018;22:252-261.e4 pubmed 出版商
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Mulas C, Kalkan T, Smith A. NODAL Secures Pluripotency upon Embryonic Stem Cell Progression from the Ground State. Stem Cell Reports. 2017;9:77-91 pubmed 出版商
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Genovese N, Domeier T, Telugu B, Roberts R. Enhanced Development of Skeletal Myotubes from Porcine Induced Pluripotent Stem Cells. Sci Rep. 2017;7:41833 pubmed 出版商
Wang L, Jiang X, Chen G, Guo W, Zhang J, Cui L, et al. Anti-tumor activity of SL4 against breast cancer cells: induction of G2/M arrest through modulation of the MAPK-dependent p21 signaling pathway. Sci Rep. 2016;6:36486 pubmed 出版商
Mou H, Vinarsky V, Tata P, Brazauskas K, Choi S, Crooke A, et al. Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells. Cell Stem Cell. 2016;19:217-231 pubmed 出版商
Zhang M, Lin Y, Sun Y, Zhu S, Zheng J, Liu K, et al. Pharmacological Reprogramming of Fibroblasts into Neural Stem Cells by Signaling-Directed Transcriptional Activation. Cell Stem Cell. 2016;18:653-67 pubmed 出版商
Drost J, Karthaus W, Gao D, Driehuis E, Sawyers C, Chen Y, et al. Organoid culture systems for prostate epithelial and cancer tissue. Nat Protoc. 2016;11:347-58 pubmed 出版商
Foulke Abel J, In J, Yin J, Zachos N, Kovbasnjuk O, Estes M, et al. Human Enteroids as a Model of Upper Small Intestinal Ion Transport Physiology and Pathophysiology. Gastroenterology. 2016;150:638-649.e8 pubmed 出版商
Mousavizadeh R, Scott A, LU A, Ardekani G, Behzad H, Lundgreen K, et al. Angiopoietin-like 4 promotes angiogenesis in the tendon and is increased in cyclically loaded tendon fibroblasts. J Physiol. 2016;594:2971-83 pubmed 出版商
Zamudio A, Wang Z, Chung S, Wolosin J. Inhibition of TGFβ cell signaling for limbal explant culture in serumless, defined xeno-free conditions. Exp Eye Res. 2016;145:48-57 pubmed 出版商
Weeber F, van de Wetering M, Hoogstraat M, Dijkstra K, Krijgsman O, Kuilman T, et al. Preserved genetic diversity in organoids cultured from biopsies of human colorectal cancer metastases. Proc Natl Acad Sci U S A. 2015;112:13308-11 pubmed 出版商
Nantasanti S, Spee B, Kruitwagen H, Chen C, Geijsen N, Oosterhoff L, et al. Disease Modeling and Gene Therapy of Copper Storage Disease in Canine Hepatic Organoids. Stem Cell Reports. 2015;5:895-907 pubmed 出版商
Kido T, Koui Y, Suzuki K, Kobayashi A, Miura Y, Chern E, et al. CPM Is a Useful Cell Surface Marker to Isolate Expandable Bi-Potential Liver Progenitor Cells Derived from Human iPS Cells. Stem Cell Reports. 2015;5:508-15 pubmed 出版商
Zhao Y, Londono P, Cao Y, Sharpe E, Proenza C, O Rourke R, et al. High-efficiency reprogramming of fibroblasts into cardiomyocytes requires suppression of pro-fibrotic signalling. Nat Commun. 2015;6:8243 pubmed 出版商
Sibony M, Abdullah M, Greenfield L, Raju D, Wu T, Rodrigues D, et al. Microbial Disruption of Autophagy Alters Expression of the RISC Component AGO2, a Critical Regulator of the miRNA Silencing Pathway. Inflamm Bowel Dis. 2015;21:2778-86 pubmed 出版商
Yang Y, Adachi K, Sheridan M, Alexenko A, Schust D, Schulz L, et al. Heightened potency of human pluripotent stem cell lines created by transient BMP4 exposure. Proc Natl Acad Sci U S A. 2015;112:E2337-46 pubmed 出版商
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Tsankov A, Gu H, Akopian V, Ziller M, Donaghey J, Amit I, et al. Transcription factor binding dynamics during human ES cell differentiation. Nature. 2015;518:344-9 pubmed 出版商
Tan J, Chan S, Lo C, Deane J, McDonald C, Bernard C, et al. Amnion cell-mediated immune modulation following bleomycin challenge: controlling the regulatory T cell response. Stem Cell Res Ther. 2015;6:8 pubmed 出版商
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Li C, Peart N, Xuan Z, Lewis D, Xia Y, Jin J. PMA induces SnoN proteolysis and CD61 expression through an autocrine mechanism. Cell Signal. 2014;26:1369-78 pubmed 出版商
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产品信息
品牌 :
Tocris
master code :
2939
SKU号 :
2939/10
产品名称 :
A 83-01
描述 :
Selective inhibitor of TGF- RI, ALK4 and ALK7
靶标 :
TGF-beta Receptor Inhibitors
类别 :
Small Molecules
单位尺寸 :
10 mg (also 50 mg)
纯度 :
98%
观察到的分子量 :
421.52
网址印刷 :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
功能细节 :
Potent inhibitor of TGF- type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 (IC50 values are 12, 45 and 7.5 nM respectively). Blocks phosphorylation of Smad2 and inhibits TGF- -induced epithelial-to-mesenchymal transition. Only weakly inhibits ALK-1, -2, -3, -6 and MAPK activity. More potent than SB 431542 (Cat.No. 1614). Inhibits differentiation of rat induced pluripotent stem cells (riPSCs) and increases clonal expansion efficiency. Helps maintain homogeneity and long-term in vitro self-renewal of human iPSCs. Also promotes neural differentiation of hPSCs as part of a chemical cocktail.
catalog number base :
2939
产品关键词 :
A83-01 Selective inhibitors inhibits TGF- RI TGF- TGF-betaRI TGFbRI TGFbR1 tgf-b1ALK4 ALK7 ALK Receptors Activin Receptor-like Kinase Serine/Threonine Kinases RSTKs Transforming Growth Factor Beta A8301 stem cells growth factors organoids diffe TGF-beta Receptors BMP and Other Activin Receptors Stem Cell Proliferation Organoids Neural Stem Cells 2939,
extended description :
Selective inhibitor of TGF- RI, ALK4 and ALK7
化学品名文本 :
3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide
配方 :
C 25 H 19 N 5秒
配方文本 :
C25H19N5S
cas num :
909910-43-6
2020美元 :
218
2021美元 :
225美元
储存 :
存放在-20°C
更多信息或购买 :
公司信息
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
公司总部: 英国