产品简要
公司名称 :
Tocris Bioscience
产品类型 :
化学品
产品名称 :
Batimastat
目录 :
2961/1
规格 :
1 mg (also 10 mg)
价格 :
189美元
更多信息或购买 :
文章摘录数: 29
参考文献
Orth He E, Huang H, Rao S, Wang Q, Chen Q, O Mara C, et al. Protein folding stress potentiates NLRP1 and CARD8 inflammasome activation. Cell Rep. 2023;42:111965 pubmed 出版商
Baggen J, Thibaut H, Hurdiss D, Wahedi M, Marceau C, van Vliet A, et al. Identification of the Cell-Surface Protease ADAM9 as an Entry Factor for Encephalomyocarditis Virus. MBio. 2019;10: pubmed 出版商
Pitt J, Wilcox K, Tortelli V, Diniz L, Oliveira M, Dobbins C, et al. Neuroprotective astrocyte-derived insulin/insulin-like growth factor 1 stimulates endocytic processing and extracellular release of neuron-bound A? oligomers. Mol Biol Cell. 2017;28:2623-2636 pubmed 出版商
Sanz R, Ferraro G, Girouard M, Fournier A. Ectodomain shedding of Limbic System-Associated Membrane Protein (LSAMP) by ADAM Metallopeptidases promotes neurite outgrowth in DRG neurons. Sci Rep. 2017;7:7961 pubmed 出版商
Lim Y, Lee M, Jeong H, Kim H. Involvement of PI3K and MMP1 in PDGF-induced Migration of Human Adipose-derived Stem Cells. Dev Reprod. 2017;21:167-180 pubmed 出版商
Ren Z, Chen J, Khalil R. Zymography as a Research Tool in the Study of Matrix Metalloproteinase Inhibitors. Methods Mol Biol. 2017;1626:79-102 pubmed 出版商
Carroll M, Kapur A, Felder M, Patankar M, Kreeger P. M2 macrophages induce ovarian cancer cell proliferation via a heparin binding epidermal growth factor/matrix metalloproteinase 9 intercellular feedback loop. Oncotarget. 2016;7:86608-86620 pubmed 出版商
Feng Z, Jia X, Adams M, Ghosh S, Bonomo R, Weinberg A. Epithelial innate immune response to Acinetobacter baumannii challenge. Infect Immun. 2014;82:4458-65 pubmed 出版商
Esteso G, Luzón E, Sarmiento E, Gómez Caro R, Steinle A, Murphy G, et al. Altered microRNA expression after infection with human cytomegalovirus leads to TIMP3 downregulation and increased shedding of metalloprotease substrates, including MICA. J Immunol. 2014;193:1344-52 pubmed 出版商
Siwetz M, Blaschitz A, Kremshofer J, Bilic J, Desoye G, Huppertz B, et al. Metalloprotease dependent release of placenta derived fractalkine. Mediators Inflamm. 2014;2014:839290 pubmed 出版商
Ji Y, Hwang Y, Mood K, Cho H, Lee H, Winterbottom E, et al. EphrinB2 affects apical constriction in Xenopus embryos and is regulated by ADAM10 and flotillin-1. Nat Commun. 2014;5:3516 pubmed 出版商
Wojtalewicz N, Sadeqzadeh E, Weiß J, Tehrani M, Klein Scory S, Hahn S, et al. A soluble form of the giant cadherin Fat1 is released from pancreatic cancer cells by ADAM10 mediated ectodomain shedding. PLoS ONE. 2014;9:e90461 pubmed 出版商
Zhou C, Petroll W. MMP regulation of corneal keratocyte motility and mechanics in 3-D collagen matrices. Exp Eye Res. 2014;121:147-60 pubmed 出版商
Woods N, Padmanabhan J. Inhibition of amyloid precursor protein processing enhances gemcitabine-mediated cytotoxicity in pancreatic cancer cells. J Biol Chem. 2013;288:30114-24 pubmed 出版商
Yoo J, Rodriguez Perez C, Nie W, Sinnett Smith J, Rozengurt E. TNF-? and LPA promote synergistic expression of COX-2 in human colonic myofibroblasts: role of LPA-mediated transactivation of upregulated EGFR. BMC Gastroenterol. 2013;13:90 pubmed 出版商
Brafman D, Phung C, Kumar N, Willert K. Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions. Cell Death Differ. 2013;20:369-81 pubmed 出版商
Yurtsever Z, Sala Rabanal M, Randolph D, Scheaffer S, Roswit W, Alevy Y, et al. Self-cleavage of human CLCA1 protein by a novel internal metalloprotease domain controls calcium-activated chloride channel activation. J Biol Chem. 2012;287:42138-49 pubmed 出版商
Mezil L, Berruyer Pouyet C, Cabaud O, Josselin E, Combes S, Brunel J, et al. Tumor selective cytotoxic action of a thiomorpholin hydroxamate inhibitor (TMI-1) in breast cancer. PLoS ONE. 2012;7:e43409 pubmed 出版商
Jijon H, Buret A, Hirota C, Hollenberg M, Beck P. The EGF receptor and HER2 participate in TNF-?-dependent MAPK activation and IL-8 secretion in intestinal epithelial cells. Mediators Inflamm. 2012;2012:207398 pubmed 出版商
Kalous A, Nangle M, Anastasía A, Hempstead B, Keast J. Neurotrophic actions initiated by proNGF in adult sensory neurons may require peri-somatic glia to drive local cleavage to NGF. J Neurochem. 2012;122:523-36 pubmed 出版商
Yin Z, Sada A, Reslan O, Narula N, Khalil R. Increased MMPs expression and decreased contraction in the rat myometrium during pregnancy and in response to prolonged stretch and sex hormones. Am J Physiol Endocrinol Metab. 2012;303:E55-70 pubmed 出版商
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Kim J, Lee J, Kim S, Choi Y, Lee W, Jeong M, et al. Thrombin-induced Migration and Matrix Metalloproteinase-9 Expression Are Regulated by MAPK and PI3K Pathways in C6 Glioma Cells. Korean J Physiol Pharmacol. 2011;15:211-6 pubmed 出版商
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Park C, Shin T, Lee H, Kim S, Lee W. Matrix metalloproteinase inhibitors attenuate neuroinflammation following focal cerebral ischemia in mice. Korean J Physiol Pharmacol. 2011;15:115-22 pubmed 出版商
Walsh L, Damjanovski S. IGF-1 increases invasive potential of MCF 7 breast cancer cells and induces activation of latent TGF-?1 resulting in epithelial to mesenchymal transition. Cell Commun Signal. 2011;9:10 pubmed 出版商
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Dang M, Dubbin K, D Aiello A, Hartmann M, Lodish H, Herrlich A. Epidermal growth factor (EGF) ligand release by substrate-specific a disintegrin and metalloproteases (ADAMs) involves different protein kinase C (PKC) isoenzymes depending on the stimulus. J Biol Chem. 2011;286:17704-13 pubmed 出版商
产品信息
品牌 :
Tocris
MasterCode :
2961
SKU号 :
2961/1
产品名称 :
Batimastat
靶标 :
Synthetic Metalloprotease Inhibitors
类别 :
Small Molecules
单位尺寸 :
1 mg (also 10 mg)
纯度 :
99%
观察到的分子量 :
477.64
网址印刷 :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
功能细节 :
Batimastat is a potent, broad spectrum MMP inhibitor (IC50 values are 3, 4, 4, 6 and 20 nM for MMP -1, -2, -9, -7 and -3 respectively). Exhibits antiproliferative, anti-invasive and antimetastatic activity in human ovarian carcinoma xenografts in vivo .
extended description :
Potent, broad spectrum MMP inhibitor
化学品名文本 :
(2R,3S)-N4-Hydroxy-N1-[(1S)-2-(methylamino)-2-oxo-1-(phenylmethyl)ethyl]-2-(2-methylpropyl)-3-[(2-thienylthio)methyl]butanediamide
配方 :
C 23 H 31 N 3 O 4秒2
配方文本 :
C23H31N3O4S2
cas num :
130370-60-4
美元 :
189美元
产品细节 :
Potent, broad spectrum MMP inhibitor
别名 :
BB-94
储存 :
存放在-20°C
更多信息或购买 :
公司信息
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
公司总部: 英国