产品简要
公司名称 :
Tocris Bioscience
产品类型 :
化学品
产品名称 :
SU 5416
目录 :
3037/10
规格 :
10 mg (also 50 mg)
价格 :
205美元
更多信息或购买 :
Tocris Bioscience 产品网页
文章摘录数: 12
参考文献
Longchamp A, Mirabella T, Arduini A, MacArthur M, Das A, Treviño Villarreal J, et al. Amino Acid Restriction Triggers Angiogenesis via GCN2/ATF4 Regulation of VEGF and H2S Production. Cell. 2018;173:117-129.e14 pubmed 出版商
Meloche J, Lampron M, Nadeau V, Maltais M, Potus F, Lambert C, et al. Implication of Inflammation and Epigenetic Readers in Coronary Artery Remodeling in Patients With Pulmonary Arterial Hypertension. Arterioscler Thromb Vasc Biol. 2017;37:1513-1523 pubmed 出版商
Neto Neves E, Brown M, Zaretskaia M, Rezania S, Goodwill A, McCarthy B, et al. Chronic Embolic Pulmonary Hypertension Caused by Pulmonary Embolism and Vascular Endothelial Growth Factor Inhibition. Am J Pathol. 2017;187:700-712 pubmed 出版商
Hurst L, Dunmore B, Long L, Crosby A, Al Lamki R, Deighton J, et al. TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling. Nat Commun. 2017;8:14079 pubmed 出版商
Happé C, de Raaf M, Rol N, Schalij I, Vonk Noordegraaf A, Westerhof N, et al. Pneumonectomy combined with SU5416 induces severe pulmonary hypertension in rats. Am J Physiol Lung Cell Mol Physiol. 2016;310:L1088-97 pubmed 出版商
Azzi S, Treps L, Leclair H, Ngo H, Harford Wright E, Gavard J. Desert Hedgehog/Patch2 Axis Contributes to Vascular Permeability and Angiogenesis in Glioblastoma. Front Pharmacol. 2015;6:281 pubmed 出版商
Long L, Ormiston M, Yang X, Southwood M, Gräf S, Machado R, et al. Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension. Nat Med. 2015;21:777-85 pubmed 出版商
Cavasin M, Demos Davies K, Schuetze K, Blakeslee W, Stratton M, Tuder R, et al. Reversal of severe angioproliferative pulmonary arterial hypertension and right ventricular hypertrophy by combined phosphodiesterase-5 and endothelin receptor inhibition. J Transl Med. 2014;12:314 pubmed 出版商
DiStefano P, Kuebel J, Sarelius I, Glading A. KRIT1 protein depletion modifies endothelial cell behavior via increased vascular endothelial growth factor (VEGF) signaling. J Biol Chem. 2014;289:33054-65 pubmed 出版商
Chabon J, Gebreab L, Kumar R, Debella E, Tanaka T, Koyanagi D, et al. Role of vascular endothelial growth factor signaling in Schistosoma-induced experimental pulmonary hypertension. Pulm Circ. 2014;4:289-99 pubmed 出版商
Hempel C, Hoyer N, Staalsø T, Kurtzhals J. Effects of the vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitor SU5416 on in vitro cultures of Plasmodium falciparum. Malar J. 2014;13:201 pubmed 出版商
Novitskiy S, Csiki I, Huang Y, Johnson D, Harth E, Carbone D, et al. Anti-vascular endothelial growth factor treatment in combination with chemotherapy delays hematopoietic recovery due to decreased proliferation of bone marrow hematopoietic progenitor cells. J Thorac Oncol. 2010;5:1410-5 pubmed 出版商
图像
图像 1 :
Tocris Bioscience 3037/10 图像 1
Cat.No. 3037 - SU 5416 C15H14N2O CAS No. 204005-46-9
产品信息
品牌 :
Tocris
MasterCode :
3037
SKU号 :
3037/10
产品名称 :
SU 5416
靶标 :
VEGF Receptor Inhibitors
类别 :
Small Molecules
单位尺寸 :
10 mg (also 50 mg)
纯度 :
99%
观察到的分子量 :
238.28
网址印刷 :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
功能细节 :
SU 5416, an angiogenesis inhibitor, is a potent vascular endothelial growth factor receptor tyrosine kinase 1/2 inhibitor (IC50 = 40 nM). SU 5416 also potently inhibits c-Kit, FLT3 and RET tyrosine kinases (IC50 values are 30 nM, 160 nM and 170 nM, respectively). SU 5416 shows inhibition of tumour growth and vascularization and can be used to generate an animal model of pulmonary arterial hypertension.
extended description :
VEGFR inhibitor. Also inhibits KIT, RET, MET and FLT3
化学品名文本 :
3-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2H-indol-2-one
配方 :
C 15 H 14 N 2 O
配方文本 :
C15H14N2O
cas num :
204005-46-9
美元 :
205美元
产品细节 :
VEGFR inhibitor. Also inhibits KIT, RET, MET and FLT3
别名 :
Semaxinib
储存 :
Desiccate at -20°C
更多信息或购买 :
Tocris Bioscience 产品网页
公司信息
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
公司总部: 英国