产品简要
公司名称 :
Tocris Bioscience
产品类型 :
化学品
产品名称 :
PD 173074
目录 :
3044/10
规格 :
10 mg (also 50 mg)
价格 :
287美元
更多信息或购买 :
Tocris Bioscience 产品网页
文章摘录数: 19
参考文献
Bise T, de Preux Charles A, Jazwinska A. Ciliary neurotrophic factor stimulates cardioprotection and the proliferative activity in the adult zebrafish heart. NPJ Regen Med. 2019;4:2 pubmed 出版商
Yuan X, Cao X, Yang S. IFT80 is required for stem cell proliferation, differentiation, and odontoblast polarization during tooth development. Cell Death Dis. 2019;10:63 pubmed 出版商
Takata N, Sakakura E, Eiraku M, Kasukawa T, Sasai Y. Self-patterning of rostral-caudal neuroectoderm requires dual role of Fgf signaling for localized Wnt antagonism. Nat Commun. 2017;8:1339 pubmed 出版商
Nacu E, Gromberg E, Oliveira C, Drechsel D, Tanaka E. FGF8 and SHH substitute for anterior-posterior tissue interactions to induce limb regeneration. Nature. 2016;533:407-10 pubmed 出版商
Lichtenberger B, Mastrogiannaki M, Watt F. Epidermal β-catenin activation remodels the dermis via paracrine signalling to distinct fibroblast lineages. Nat Commun. 2016;7:10537 pubmed 出版商
Anreddy N, Patel A, Sodani K, Kathawala R, Chen E, Wurpel J, et al. PD173074, a selective FGFR inhibitor, reverses MRP7 (ABCC10)-mediated MDR. Acta Pharm Sin B. 2014;4:202-7 pubmed 出版商
MacKenzie B, Korfei M, Henneke I, Sibinska Z, Tian X, Hezel S, et al. Increased FGF1-FGFRc expression in idiopathic pulmonary fibrosis. Respir Res. 2015;16:83 pubmed 出版商
Yang J, Kaur K, Ong L, Eisenberg C, Eisenberg L. Inhibition of G9a Histone Methyltransferase Converts Bone Marrow Mesenchymal Stem Cells to Cardiac Competent Progenitors. Stem Cells Int. 2015;2015:270428 pubmed 出版商
Knuchel S, Anderle P, Werfelli P, Diamantis E, Rüegg C. Fibroblast surface-associated FGF-2 promotes contact-dependent colorectal cancer cell migration and invasion through FGFR-SRC signaling and integrin αvβ5-mediated adhesion. Oncotarget. 2015;6:14300-17 pubmed
Benzina S, Pitaval A, Lemercier C, Lustremant C, Frouin V, Wu N, et al. A kinome-targeted RNAi-based screen links FGF signaling to H2AX phosphorylation in response to radiation. Cell Mol Life Sci. 2015;72:3559-73 pubmed 出版商
Saito S, Morishima K, Ui T, Hoshino H, Matsubara D, Ishikawa S, et al. The role of HGF/MET and FGF/FGFR in fibroblast-derived growth stimulation and lapatinib-resistance of esophageal squamous cell carcinoma. BMC Cancer. 2015;15:82 pubmed 出版商
Witty A, Mihic A, Tam R, Fisher S, Mikryukov A, Shoichet M, et al. Generation of the epicardial lineage from human pluripotent stem cells. Nat Biotechnol. 2014;32:1026-35 pubmed 出版商
Rankin S, Thi Tran H, Wlizla M, Mancini P, Shifley E, Bloor S, et al. A Molecular atlas of Xenopus respiratory system development. Dev Dyn. 2015;244:69-85 pubmed 出版商
Rodriguez A, Allegrucci C, Alberio R. Modulation of pluripotency in the porcine embryo and iPS cells. PLoS ONE. 2012;7:e49079 pubmed 出版商
Shifley E, Kenny A, Rankin S, Zorn A. Prolonged FGF signaling is necessary for lung and liver induction in Xenopus. BMC Dev Biol. 2012;12:27 pubmed 出版商
Rankin S, Gallas A, Neto A, Gomez Skarmeta J, Zorn A. Suppression of Bmp4 signaling by the zinc-finger repressors Osr1 and Osr2 is required for Wnt/β-catenin-mediated lung specification in Xenopus. Development. 2012;139:3010-20 pubmed 出版商
Cho L, Wamaitha S, Tsai I, Artus J, Sherwood R, Pedersen R, et al. Conversion from mouse embryonic to extra-embryonic endoderm stem cells reveals distinct differentiation capacities of pluripotent stem cell states. Development. 2012;139:2866-77 pubmed 出版商
Wilson T, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature. 2012;487:505-9 pubmed 出版商
Gibson N, Tolbert L, Oland L. Activation of glial FGFRs is essential in glial migration, proliferation, and survival and in glia-neuron signaling during olfactory system development. PLoS ONE. 2012;7:e33828 pubmed 出版商
产品信息
品牌 :
Tocris
MasterCode :
3044
SKU号 :
3044/10
产品名称 :
PD 173074
靶标 :
FGF Receptor Inhibitors
类别 :
Small Molecules
单位尺寸 :
10 mg (also 50 mg)
纯度 :
98%
观察到的分子量 :
523.67
网址印刷 :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
功能细节 :
PD 173074 is a selective FGFR1 and FGFR3 inhibitor (IC50 values are 5, 21.5, ~100, 17600 and 19800 nM for FGFR3, FGFR1, VEGFR2, PDGFR and c-Src respectively, and 50000 nM for EGFR, InsR, MEK and PKC). Inhibits VEGF- and FGF-induced angiogenesis in the mouse cornea model of angiogenesis. Inhibits proliferation and differentiation of oligodendrocyte progenitors. Also promotes mESC self-renewal, facilitates the conversion of mouse epiblast stem cells to an earlier pluripotency state and inhibits differentiation of miPSCs to cardiomyocytes. Suppresses cell proliferation in cell lines expressing mutated FGFR3 protein. Blocks tumor growth in H510 and H69 SCLC xenograft models.
extended description :
FGFR1 and -3 inhibitor
化学品名文本 :
N-[2-[[4-(Diethylamino)butyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N -(1,1-dimethylethyl)urea
配方 :
C 28 H 41 N 7 O 3
配方文本 :
C28H41N7O3
cas num :
219580-11-7
美元 :
287美元
产品细节 :
FGFR1 and -3 inhibitor
储存 :
存放在+4°C
更多信息或购买 :
Tocris Bioscience 产品网页
公司信息
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
公司总部: 英国