产品简要
公司名称 :
Tocris Bioscience
产品类型 :
化学品
产品名称 :
SU 5402
目录 :
3300/1
规格 :
1毫克
价格 :
326美元
更多信息或购买 :
Tocris Bioscience 产品网页
文章摘录数: 17
参考文献
Gibb N, Lazic S, Yuan X, Deshwar A, Leslie M, Wilson M, et al. Hey2 regulates the size of the cardiac progenitor pool during vertebrate heart development. Development. 2018;145: pubmed 出版商
Yang J, Ryan D, Wang W, Tsang J, Lan G, Masaki H, et al. Establishment of mouse expanded potential stem cells. Nature. 2017;550:393-397 pubmed 出版商
Yan C, Yang Q, Huo X, Li H, Zhou L, Gong Z. Chemical inhibition reveals differential requirements of signaling pathways in krasV12- and Myc-induced liver tumors in transgenic zebrafish. Sci Rep. 2017;7:45796 pubmed 出版商
Rodrigues A, Yakushiji Kaminatsui N, Atsuta Y, Andrey G, Schorderet P, Duboule D, et al. Integration of Shh and Fgf signaling in controlling Hox gene expression in cultured limb cells. Proc Natl Acad Sci U S A. 2017;114:3139-3144 pubmed 出版商
Li M, Page McCaw P, Chen W. FGF1 Mediates Overnutrition-Induced Compensatory β-Cell Differentiation. Diabetes. 2016;65:96-109 pubmed 出版商
Cunningham T, Brade T, Sandell L, Lewandoski M, Trainor P, Colas A, et al. Retinoic Acid Activity in Undifferentiated Neural Progenitors Is Sufficient to Fulfill Its Role in Restricting Fgf8 Expression for Somitogenesis. PLoS ONE. 2015;10:e0137894 pubmed 出版商
Benzina S, Pitaval A, Lemercier C, Lustremant C, Frouin V, Wu N, et al. A kinome-targeted RNAi-based screen links FGF signaling to H2AX phosphorylation in response to radiation. Cell Mol Life Sci. 2015;72:3559-73 pubmed 出版商
Dean B, Erdoğan B, Gamse J, Wu S. Dbx1b defines the dorsal habenular progenitor domain in the zebrafish epithalamus. Neural Dev. 2014;9:20 pubmed 出版商
Chen J, Galloway J. The development of zebrafish tendon and ligament progenitors. Development. 2014;141:2035-45 pubmed 出版商
Bernet J, Doles J, Hall J, Kelly Tanaka K, Carter T, Olwin B. p38 MAPK signaling underlies a cell-autonomous loss of stem cell self-renewal in skeletal muscle of aged mice. Nat Med. 2014;20:265-71 pubmed 出版商
Dai W, Bai Y, Hebda L, Zhong X, Liu J, Kao J, et al. Calcium deficiency-induced and TRP channel-regulated IGF1R-PI3K-Akt signaling regulates abnormal epithelial cell proliferation. Cell Death Differ. 2014;21:568-81 pubmed 出版商
Neugebauer J, Yost H. FGF signaling is required for brain left-right asymmetry and brain midline formation. Dev Biol. 2014;386:123-34 pubmed 出版商
Hashiguchi M, Mullins M. Anteroposterior and dorsoventral patterning are coordinated by an identical patterning clock. Development. 2013;140:1970-80 pubmed 出版商
Clanton J, Hope K, Gamse J. Fgf signaling governs cell fate in the zebrafish pineal complex. Development. 2013;140:323-32 pubmed 出版商
Rankin S, Gallas A, Neto A, Gomez Skarmeta J, Zorn A. Suppression of Bmp4 signaling by the zinc-finger repressors Osr1 and Osr2 is required for Wnt/β-catenin-mediated lung specification in Xenopus. Development. 2012;139:3010-20 pubmed 出版商
Sato A, Scholl A, Kuhn E, Kuhn E, Stadt H, Decker J, et al. FGF8 signaling is chemotactic for cardiac neural crest cells. Dev Biol. 2011;354:18-30 pubmed 出版商
Tan T, Tang X, Zhang J, Niu Y, Chen H, Li B, et al. Generation of trophoblast stem cells from rabbit embryonic stem cells with BMP4. PLoS ONE. 2011;6:e17124 pubmed 出版商
产品信息
品牌 :
Tocris, a Bio-Techne Brand
catalog number base :
3300
SKU号 :
3300/1
产品名称 :
SU 5402
描述 :
Potent FGFR and VEGFR inhibitor
靶标 :
FGF Receptor Inhibitors
类别 :
Small Molecules
单位尺寸 :
1毫克
纯度 :
95%
观察到的分子量 :
296.32
网址印刷 :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
功能细节 :
SU 5402 is a potent and selective vascular endothelial growth factor receptor (VEGFR) and fibroblast growth factor receptor (FGFR) inhibitor (IC50 values are 0.02, 0.03, 0.51 and 100 M at VEGFR2, FGFR1, PDGFR and EGFR respectively). Inhibits embryonic left-right determination and exhibits potent anticancer activity in vitro and in vivo . Also attenuates integrin 4-induced differentiation of neural stem cells. Supports mESC self-renewal. . For more information about how SU 5402 may be used, see our protocol: Accelerated Induction of Cortical Neurons from hiPSCs
extended description :
Potent FGFR and VEGFR inhibitor
化学品名文本 :
2-[(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl]-4-methyl-1H-pyrrole-3-propanoic acid
配方 :
C 17 H 16 N 2 O 3
配方文本 :
C17H16N2O3
cas num :
215543-92-3
美元 :
326美元
产品细节 :
Potent FGFR and VEGFR inhibitor
储存 :
存放在-20°C
更多信息或购买 :
Tocris Bioscience 产品网页
公司信息
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
公司总部: 英国