This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
产品简要
公司名称 :
Tocris Bioscience
产品类型 :
化学品
产品名称 :
Zileuton
目录 :
3308/50
规格 :
50毫克
价格 :
215美元
文章摘录数: 7
参考文献
Oguh Olayinka L, Agarwal V, Ranatunge D, Campbell A, Laufer S, Cawkwell L, et al. The Investigation of Lipoxygenases as Therapeutic Targets in Malignant Pleural Mesothelioma. Pathol Oncol Res. 2019;: pubmed 出版商
Li C, Deng X, Xie X, Liu Y, Friedmann Angeli J, Lai L. Activation of Glutathione Peroxidase 4 as a Novel Anti-inflammatory Strategy. Front Pharmacol. 2018;9:1120 pubmed 出版商
Sharma Walia N, Chandran K, Patel K, Veettil M, Marginean A. The Kaposi's sarcoma-associated herpesvirus (KSHV)-induced 5-lipoxygenase-leukotriene B4 cascade plays key roles in KSHV latency, monocyte recruitment, and lipogenesis. J Virol. 2014;88:2131-56 pubmed 出版商
Chang T, Uen Y, Chou C, Sheu J, Chou D. The role of cyclooxygenase-derived oxidative stress in surgically induced lymphedema in a mouse tail model. Pharm Biol. 2013;51:573-80 pubmed 出版商
Mothe Satney I, Filloux C, Amghar H, Pons C, Bourlier V, Galitzky J, et al. Adipocytes secrete leukotrienes: contribution to obesity-associated inflammation and insulin resistance in mice. Diabetes. 2012;61:2311-9 pubmed 出版商
Gregus A, Doolen S, Dumlao D, Buczynski M, Takasusuki T, Fitzsimmons B, et al. Spinal 12-lipoxygenase-derived hepoxilin A3 contributes to inflammatory hyperalgesia via activation of TRPV1 and TRPA1 receptors. Proc Natl Acad Sci U S A. 2012;109:6721-6 pubmed 出版商
Jiang Z, Yin X, Jiang Q. Natural forms of vitamin E and 13'-carboxychromanol, a long-chain vitamin E metabolite, inhibit leukotriene generation from stimulated neutrophils by blocking calcium influx and suppressing 5-lipoxygenase activity, respectively. J Immunol. 2011;186:1173-9 pubmed 出版商
产品信息
品牌 :
Tocris
master code :
3308
SKU号 :
3308/50
产品名称 :
Zileuton
描述 :
5-LOX inhibitor; orally bioavailable
靶标 :
脂肪氧化酶抑制剂
类别 :
Small Molecules
单位尺寸 :
50毫克
纯度 :
99%
观察到的分子量 :
236.29
网址印刷 :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
功能细节 :
Zileuton is an orally active 5-lipoxygenase (5-LOX) inhibitor that inhibits LTB4 synthesis (IC50 values are 0.56, 2.3 and 2.6 M in dog, rat and human blood respectively). Inhibits antigen-induced contraction of tracheal strips in vitro (IC50 = 6 M) and exhibits antiasthmatic activity in vivo . Also weakly inhibits CYP1A2 (Ki = 66 - 98 M). Ferroptosis inhibitor.
catalog number base :
3308
extended description :
5-LOX inhibitor; orally bioavailable
化学品名文本 :
N-(1-Benzo[b]thien-2-ylethyl)-N-hydroxyurea
配方 :
C 11 H 12 N 2 O 2秒
配方文本 :
C11H12N2O2S
cas num :
111406-87-2
美元2021 :
201
美元2022 :
215美元
产品细节 :
5-LOX inhibitor; orally bioavailable
atl names :
ICI D2138
储存 :
存放在+4°C
公司信息
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
公司总部: 英国