产品简要
公司名称 :
Tocris Bioscience
产品类型 :
化学品
产品名称 :
A 769662
目录 :
3336/10
规格 :
10 mg (also 50 mg)
价格 :
269美元
更多信息或购买 :
文章摘录数: 24
参考文献
Ahwazi D, Neopane K, Markby G, Kopietz F, Ovens A, Dall M, et al. Investigation of the specificity and mechanism of action of the ULK1/AMPK inhibitor SBI-0206965. Biochem J. 2021;478:2977-2997 pubmed 出版商
Paige C, Mejia G, Dussor G, PRICE T. AMPK activation regulates P-body dynamics in mouse sensory neurons in vitro and in vivo. Neurobiol Pain. 2019;5: pubmed 出版商
Lee J, Lee J, Cho Y. Peroxisome Proliferator-Activated Receptor α Agonist and Its Target Nanog Cooperate to Induce Pluripotency. J Clin Med. 2018;7: pubmed 出版商
Hamann J, Surcel A, Chen R, Teragawa C, Albeck J, Robinson D, et al. Entosis Is Induced by Glucose Starvation. Cell Rep. 2017;20:201-210 pubmed 出版商
Dai S, Dulcey A, Hu X, Wassif C, Porter F, Austin C, et al. Methyl-β-cyclodextrin restores impaired autophagy flux in Niemann-Pick C1-deficient cells through activation of AMPK. Autophagy. 2017;13:1435-1451 pubmed 出版商
Vlachaki Walker J, Robb J, Cruz A, Malhi A, Weightman Potter P, Ashford M, et al. AMP-activated protein kinase (AMPK) activator A-769662 increases intracellular calcium and ATP release from astrocytes in an AMPK-independent manner. Diabetes Obes Metab. 2017;19:997-1005 pubmed 出版商
Mahapatra G, Varughese A, Ji Q, Lee I, Liu J, Vaishnav A, et al. Phosphorylation of Cytochrome c Threonine 28 Regulates Electron Transport Chain Activity in Kidney: IMPLICATIONS FOR AMP KINASE. J Biol Chem. 2017;292:64-79 pubmed 出版商
Muller Durovic B, Lanna A, Covre L, Mills R, Henson S, Akbar A. Killer Cell Lectin-like Receptor G1 Inhibits NK Cell Function through Activation of Adenosine 5'-Monophosphate-Activated Protein Kinase. J Immunol. 2016;197:2891-2899 pubmed 出版商
Walter C, Clemens L, Müller A, Fallier Becker P, Proikas Cezanne T, Riess O, et al. Activation of AMPK-induced autophagy ameliorates Huntington disease pathology in vitro. Neuropharmacology. 2016;108:24-38 pubmed 出版商
Saric A, Hipolito V, Kay J, Canton J, Antonescu C, Botelho R. mTOR controls lysosome tubulation and antigen presentation in macrophages and dendritic cells. Mol Biol Cell. 2016;27:321-33 pubmed 出版商
Hwang J, Kim Y, Noh J, Choi D, Kim K, Lee C. Enhanced Production of Adenosine Triphosphate by Pharmacological Activation of Adenosine Monophosphate-Activated Protein Kinase Ameliorates Acetaminophen-Induced Liver Injury. Mol Cells. 2015;38:843-50 pubmed 出版商
Peart T, Ramos Valdes Y, Correa R, Fazio E, Bertrand M, McGee J, et al. Intact LKB1 activity is required for survival of dormant ovarian cancer spheroids. Oncotarget. 2015;6:22424-38 pubmed
Mo J, Meng Z, Kim Y, Park H, Hansen C, Kim S, et al. Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway. Nat Cell Biol. 2015;17:500-10 pubmed 出版商
Kenney J, Sorokina O, Genheden M, Sorokin A, Armstrong J, Proud C. Dynamics of elongation factor 2 kinase regulation in cortical neurons in response to synaptic activity. J Neurosci. 2015;35:3034-47 pubmed 出版商
López Cotarelo P, Escribano Díaz C, González Bethencourt I, Gómez Moreira C, Deguiz M, Torres Bacete J, et al. A novel MEK-ERK-AMPK signaling axis controls chemokine receptor CCR7-dependent survival in human mature dendritic cells. J Biol Chem. 2015;290:827-40 pubmed 出版商
Weikel K, Cacicedo J, Ruderman N, Ido Y. Glucose and palmitate uncouple AMPK from autophagy in human aortic endothelial cells. Am J Physiol Cell Physiol. 2015;308:C249-63 pubmed 出版商
Melemedjian O, Mejia G, Lepow T, Zoph O, Price T. Bidirectional regulation of P body formation mediated by eIF4F complex formation in sensory neurons. Neurosci Lett. 2014;563:169-74 pubmed 出版商
Wu N, Zheng B, SHAYWITZ A, Dagon Y, Tower C, Bellinger G, et al. AMPK-dependent degradation of TXNIP upon energy stress leads to enhanced glucose uptake via GLUT1. Mol Cell. 2013;49:1167-75 pubmed 出版商
Lo B, Strasser G, Sagolla M, Austin C, Junttila M, Mellman I. Lkb1 regulates organogenesis and early oncogenesis along AMPK-dependent and -independent pathways. J Cell Biol. 2012;199:1117-30 pubmed 出版商
Mack H, Zheng B, Asara J, Thomas S. AMPK-dependent phosphorylation of ULK1 regulates ATG9 localization. Autophagy. 2012;8:1197-214 pubmed 出版商
Zhang Y, Qiu J, Wang X, Zhang Y, Xia M. AMP-activated protein kinase suppresses endothelial cell inflammation through phosphorylation of transcriptional coactivator p300. Arterioscler Thromb Vasc Biol. 2011;31:2897-908 pubmed 出版商
Bumpus N, Johnson E. 5-Aminoimidazole-4-carboxyamide-ribonucleoside (AICAR)-stimulated hepatic expression of Cyp4a10, Cyp4a14, Cyp4a31, and other peroxisome proliferator-activated receptor α-responsive mouse genes is AICAR 5'-monophosphate-dependent and AMP-activated pro. J Pharmacol Exp Ther. 2011;339:886-95 pubmed 出版商
Paiva M, Rutter Locher Z, Goncalves L, Providencia L, Davidson S, Yellon D, et al. Enhancing AMPK activation during ischemia protects the diabetic heart against reperfusion injury. Am J Physiol Heart Circ Physiol. 2011;300:H2123-34 pubmed 出版商
Terkeltaub R, Yang B, Lotz M, Liu Bryan R. Chondrocyte AMP-activated protein kinase activity suppresses matrix degradation responses to proinflammatory cytokines interleukin-1? and tumor necrosis factor ?. Arthritis Rheum. 2011;63:1928-37 pubmed 出版商
产品信息
品牌 :
Tocris, a Bio-Techne Brand
catalog number base :
3336
SKU号 :
3336/10
产品名称 :
A 769662
描述 :
Potent AMPK activator
靶标 :
AMPK Activators
类别 :
Small Molecules
单位尺寸 :
10 mg (also 50 mg)
纯度 :
98%
观察到的分子量 :
360.39
网址印刷 :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
功能细节 :
A 769662 is a potent, reversible AMP-activated protein kinase (AMPK) activator (EC50 = 0.8 M) that displays selectivity towards 1 subunit-containing heterotrimers. Inhibits fatty acid synthesis (IC50 = 3.2 M) and decreases plasma glucose and triglyceride levels in vivo . Also inhibits proliferation of mesenchymal stem cells, and impedes reprogramming of mouse embryonic fibroblasts to iPSCs. Activates autophagy.
extended description :
Potent AMPK activator
化学品名文本 :
6,7-Dihydro-4-hydroxy-3-(2 -hydroxy[1,1 -biphenyl]-4-yl)-6-oxo-thieno[2,3-b]pyridine-5-carbonitrile
配方 :
C 20 H 12 N 2 O 3秒
配方文本 :
C20H12N2O3S
cas num :
844499-71-4
美元 :
269美元
产品细节 :
Potent AMPK activator
储存 :
存放在+4°C
更多信息或购买 :
公司信息
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
公司总部: 英国