产品简要
公司名称 :
Tocris Bioscience
产品类型 :
化学品
产品名称 :
(Z)-4-Hydroxytamoxifen
目录 :
3412/10
规格 :
10 mg (also 50 mg)
价格 :
238美元
更多信息或购买 :
Tocris Bioscience 产品网页
文章摘录数: 5
参考文献
Chatterjee S, Bhat V, Berdnikov A, Liu J, Zhang G, Buchel E, et al. Paracrine Crosstalk between Fibroblasts and ER+ Breast Cancer Cells Creates an IL1β-Enriched Niche that Promotes Tumor Growth. iScience. 2019;19:388-401 pubmed 出版商
Zhang W, Chronis C, Chen X, Zhang H, Spalinskas R, Pardo M, et al. The BAF and PRC2 Complex Subunits Dpf2 and Eed Antagonistically Converge on Tbx3 to Control ESC Differentiation. Cell Stem Cell. 2019;24:138-152.e8 pubmed 出版商
Ito K, Park S, Katsyv I, Zhang W, De Angelis C, Schiff R, et al. PTK6 regulates growth and survival of endocrine therapy-resistant ER+ breast cancer cells. NPJ Breast Cancer. 2017;3:45 pubmed 出版商
Lee M, Koh D, Na H, Ka N, Kim S, Kim H, et al. MTA1 is a novel regulator of autophagy that induces tamoxifen resistance in breast cancer cells. Autophagy. 2017;: pubmed 出版商
Candelaria N, Weldon R, Muthusamy S, Nguyen Vu T, Addanki S, Yoffou P, et al. Alcohol Regulates Genes that Are Associated with Response to Endocrine Therapy and Attenuates the Actions of Tamoxifen in Breast Cancer Cells. PLoS ONE. 2015;10:e0145061 pubmed 出版商
产品信息
品牌 :
Tocris, a Bio-Techne Brand
catalog number base :
3412
SKU号 :
3412/10
产品名称 :
(Z)-4-Hydroxytamoxifen
描述 :
Metabolite of tamoxifen (Cat. No. 0999)
靶标 :
Estrogen and Related Receptor Modulators
类别 :
Small Molecules
单位尺寸 :
10 mg (also 50 mg)
纯度 :
98%
观察到的分子量 :
387.51
网址印刷 :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
功能细节 :
( Z )-4-Hydroxytamoxifen is an estrogen receptor antagonist (IC50 = 27 M). ( Z )-4-Hydroxytamoxifen is a Tamoxifen (Cat. No. 0999) metabolite; that exhibits greater potency than the parent compound. ( Z )-4-Hydroxytamoxifen also activates intein-linked inactive Cas9, reducing off-target CRISPR-mediated gene editing; system has ~25-fold higher specificity than wtCas9. ( Z )-4-Hydroxytamoxifen binds to voltage-gated sodium channels, near the intracellular gate and inhibits the sodium current by delaying channel recovery from the inactivated state (IC50 values are 297 nM and 2.1 ?M for NavM and human Nav, respectively in HEK cells); this inhibition is independent of estrogen receptor modulation. Chemotherapeutic agent.
extended description :
Metabolite of tamoxifen (Cat. No. 0999)
化学品名文本 :
4-[(1Z)-1-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]phenol
配方 :
C 26 H 29 NO 2
配方文本 :
C26H29NO2
cas num :
68047-06-3
美元 :
238美元
产品细节 :
Metabolite of tamoxifen (Cat. No. 0999)
别名 :
4-OH-TAM
储存 :
存放在+4°C
更多信息或购买 :
Tocris Bioscience 产品网页
公司信息
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
公司总部: 英国