产品简要
公司名称 :
Tocris Bioscience
产品类型 :
化学品
产品名称 :
(5Z)-7-Oxozeaenol
目录 :
3604/1
规格 :
1毫克
价格 :
222美元
更多信息或购买 :
文章摘录数: 40
参考文献
Maddali P, Ambesi A, McKeown Longo P. Induction of pro-inflammatory genes by fibronectin DAMPs in three fibroblast cell lines: Role of TAK1 and MAP kinases. PLoS ONE. 2023;18:e0286390 pubmed 出版商
Hughes S, Lin M, Weir A, Huang B, Xiong L, Chua N, et al. Caspase-8-driven apoptotic and pyroptotic crosstalk causes cell death and IL-1β release in X-linked inhibitor of apoptosis (XIAP) deficiency. EMBO J. 2023;42:e110468 pubmed 出版商
Carrillo C, Ravi V, Tiwari S, Chernoff E, Belecky Adams T. TAK1 inhibition increases proliferation and differentiation of chick retinal cells. Front Cell Dev Biol. 2022;10:698233 pubmed 出版商
Rodrigues M, Petrova T, Tibbs B, Arthur J, Cohen P. TAK1 protein kinase activity is required for TLR signalling and cytokine production in myeloid cells. Biochem J. 2022;479:1891-1907 pubmed 出版商
Moser R, Annis J, Nikolova O, Whatcott C, Gurley K, Mendez E, et al. Pharmacologic Targeting of TFIIH Suppresses KRAS-Mutant Pancreatic Ductal Adenocarcinoma and Synergizes with TRAIL. Cancer Res. 2022;82:3375-3393 pubmed 出版商
Wang J, Tseng C, Lin F, Chen J, Hsieh E, Lama S, et al. Topical application of TAK1 inhibitor encapsulated by gelatin particle alleviates corneal neovascularization. Theranostics. 2022;12:657-674 pubmed 出版商
Chen T, Du W, Junco J, Bridges C, Shen Y, Puppi M, et al. Inhibition of the MAP2K7-JNK pathway with 5Z-7-oxozeaenol induces apoptosis in T-cell acute lymphoblastic leukemia. Oncotarget. 2021;12:1787-1801 pubmed 出版商
Cibi D, Sandireddy R, Bogireddi H, Tee N, Ghani S, Singh B, et al. Cardiac Tissue Factor Regulates Inflammation, Hypertrophy, and Heart Failure in Mouse Model of Type 1 Diabetes. Diabetes. 2021;70:2131-2146 pubmed 出版商
Wang C, Shen J, Ying J, Xiao D, O Keefe R. FoxO1 is a crucial mediator of TGF-β/TAK1 signaling and protects against osteoarthritis by maintaining articular cartilage homeostasis. Proc Natl Acad Sci U S A. 2020;117:30488-30497 pubmed 出版商
Jin J, Jung I, Moon S, Jeon S, Jeong S, Sonn S, et al. CD137 Signaling Regulates Acute Colitis via RALDH2-Expressing CD11b-CD103+ DCs. Cell Rep. 2020;30:4124-4136.e5 pubmed 出版商
Ariana A, Alturki N, Hajjar S, Stumpo D, Tiedje C, Alnemri E, et al. Tristetraprolin regulates necroptosis during tonic Toll-like receptor 4 (TLR4) signaling in murine macrophages. J Biol Chem. 2020;295:4661-4672 pubmed 出版商
Zonneville J, Wong V, Limoge M, NIKIFOROV M, Bakin A. TAK1 signaling regulates p53 through a mechanism involving ribosomal stress. Sci Rep. 2020;10:2517 pubmed 出版商
Kehl S, Soos B, Saha B, Choi S, Herren A, Johansen T, et al. TAK1 converts Sequestosome 1/p62 from an autophagy receptor to a signaling platform. EMBO Rep. 2019;20:e46238 pubmed 出版商
Lionarons D, Hancock D, Rana S, East P, Moore C, Murillo M, et al. RAC1P29S Induces a Mesenchymal Phenotypic Switch via Serum Response Factor to Promote Melanoma Development and Therapy Resistance. Cancer Cell. 2019;: pubmed 出版商
Fleskens V, Minutti C, Wu X, Wei P, Pals C, McCrae J, et al. Nemo-like Kinase Drives Foxp3 Stability and Is Critical for Maintenance of Immune Tolerance by Regulatory T Cells. Cell Rep. 2019;26:3600-3612.e6 pubmed 出版商
Hilt Z, Pariser D, Ture S, Mohan A, Quijada P, Asante A, et al. Platelet-derived β2M regulates monocyte inflammatory responses. JCI Insight. 2019;: pubmed 出版商
Iriondo O, Liu Y, Lee G, Elhodaky M, Jimenez C, Li L, et al. TAK1 mediates microenvironment-triggered autocrine signals and promotes triple-negative breast cancer lung metastasis. Nat Commun. 2018;9:1994 pubmed 出版商
Jones D, Jenney A, Joughin B, Sorger P, Lauffenburger D. Inflammatory but not mitogenic contexts prime synovial fibroblasts for compensatory signaling responses to p38 inhibition. Sci Signal. 2018;11: pubmed 出版商
Annibaldi A, Wicky John S, Vanden Berghe T, Swatek K, Ruan J, Liccardi G, et al. Ubiquitin-Mediated Regulation of RIPK1 Kinase Activity Independent of IKK and MK2. Mol Cell. 2018;69:566-580.e5 pubmed 出版商
Lu L, Zhang X, Tong H, Zhang W, Xu P, Qu S. Central Administration of 5Z-7-Oxozeaenol Protects Experimental Autoimmune Encephalomyelitis Mice by Inhibiting Microglia Activation. Front Pharmacol. 2017;8:789 pubmed 出版商
Yang Y, Qiu Y, Tang M, Wu Z, Hu W, Chen C. Expression and function of transforming growth factor‑β‑activated protein kinase 1 in gastric cancer. Mol Med Rep. 2017;16:3103-3110 pubmed 出版商
Shen H, Li L, Yang S, Wang D, Zhou S, Chen X, et al. Regulatory role of tumor necrosis factor receptor-associated factor 6 in breast cancer by activating the protein kinase B/glycogen synthase kinase 3β signaling pathway. Mol Med Rep. 2017;16:2269-2273 pubmed 出版商
van Caam A, Madej W, García de Vinuesa A, Goumans M, Ten Dijke P, Blaney Davidson E, et al. TGF?1-induced SMAD2/3 and SMAD1/5 phosphorylation are both ALK5-kinase-dependent in primary chondrocytes and mediated by TAK1 kinase activity. Arthritis Res Ther. 2017;19:112 pubmed 出版商
Jaco I, Annibaldi A, Lalaoui N, Wilson R, Tenev T, Laurien L, et al. MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death. Mol Cell. 2017;66:698-710.e5 pubmed 出版商
Jones D, Jenney A, Swantek J, Burke J, Lauffenburger D, Sorger P. Profiling drugs for rheumatoid arthritis that inhibit synovial fibroblast activation. Nat Chem Biol. 2017;13:38-45 pubmed 出版商
Ismail H, Didangelos A, Vincent T, Saklatvala J. Rapid Activation of Transforming Growth Factor ?-Activated Kinase 1 in Chondrocytes by Phosphorylation and K63 -Linked Polyubiquitination Upon Injury to Animal Articular Cartilage. Arthritis Rheumatol. 2017;69:565-575 pubmed 出版商
Thamodaran V, Bruce A. p38 (Mapk14/11) occupies a regulatory node governing entry into primitive endoderm differentiation during preimplantation mouse embryo development. Open Biol. 2016;6: pubmed 出版商
Kim M, Caplen N, Chakka S, Hernandez L, House C, Pongas G, et al. Identification of therapeutic targets applicable to clinical strategies in ovarian cancer. BMC Cancer. 2016;16:678 pubmed 出版商
Venna V, Benashski S, Chauhan A, McCullough L. Inhibition of glycogen synthase kinase-3β enhances cognitive recovery after stroke: the role of TAK1. Learn Mem. 2015;22:336-43 pubmed 出版商
Kuk H, Hutchenreuther J, Murphy Marshman H, Carter D, Leask A. 5Z-7-Oxozeanol Inhibits the Effects of TGFβ1 on Human Gingival Fibroblasts. PLoS ONE. 2015;10:e0123689 pubmed 出版商
Huang H, Chiang C, Hung W, Hou M. Targeting of TGF-β-activated protein kinase 1 inhibits chemokine (C-C motif) receptor 7 expression, tumor growth and metastasis in breast cancer. Oncotarget. 2015;6:995-1007 pubmed
Graham S, Wicher K, Jedrusik A, Guo G, Herath W, Robson P, et al. BMP signalling regulates the pre-implantation development of extra-embryonic cell lineages in the mouse embryo. Nat Commun. 2014;5:5667 pubmed 出版商
Zhang Z, Li S, Zhang H, Wu Q, Gong J, Liang T, et al. Stabilization of ATF5 by TAK1-Nemo-like kinase critically regulates the interleukin-1β-stimulated C/EBP signaling pathway. Mol Cell Biol. 2015;35:778-88 pubmed 出版商
van Beuningen H, de Vries van Melle M, Vitters E, Schreurs W, van den Berg W, van Osch G, et al. Inhibition of TAK1 and/or JAK can rescue impaired chondrogenic differentiation of human mesenchymal stem cells in osteoarthritis-like conditions. Tissue Eng Part A. 2014;20:2243-52 pubmed 出版商
Ansell S, Hodge L, Secreto F, Manske M, Braggio E, Price Troska T, et al. Activation of TAK1 by MYD88 L265P drives malignant B-cell Growth in non-Hodgkin lymphoma. Blood Cancer J. 2014;4:e183 pubmed 出版商
Olsen K, Epa A, Kulkarni A, Kottmann R, McCarthy C, Johnson G, et al. Inhibition of transglutaminase 2, a novel target for pulmonary fibrosis, by two small electrophilic molecules. Am J Respir Cell Mol Biol. 2014;50:737-47 pubmed 出版商
Choi H, Kim J, Do K, Park S, Moon Y. Prolonged NF-?B activation by a macrophage inhibitory cytokine 1-linked signal in enteropathogenic Escherichia coli-infected epithelial cells. Infect Immun. 2013;81:1860-9 pubmed 出版商
White B, Tarabishy S, Venna V, Manwani B, Benashski S, McCullough L, et al. Protection from cerebral ischemia by inhibition of TGFβ-activated kinase. Exp Neurol. 2012;237:238-45 pubmed 出版商
Ahmed N, Zeng M, Sinha I, Polin L, Wei W, Rathinam C, et al. The E3 ligase Itch and deubiquitinase Cyld act together to regulate Tak1 and inflammation. Nat Immunol. 2011;12:1176-83 pubmed 出版商
Morimoto R, Shindou H, Oda Y, Shimizu T. Phosphorylation of lysophosphatidylcholine acyltransferase 2 at Ser34 enhances platelet-activating factor production in endotoxin-stimulated macrophages. J Biol Chem. 2010;285:29857-62 pubmed 出版商
产品信息
品牌 :
Tocris, a Bio-Techne Brand
catalog number base :
3604
SKU号 :
3604/1
产品名称 :
(5Z)-7-Oxozeaenol
描述 :
Potent and selective TAK1 MAPKKK inhibitor
靶标 :
Other Kinase Inhibitors
类别 :
Small Molecules
单位尺寸 :
1毫克
纯度 :
98%
观察到的分子量 :
362.37
网址印刷 :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
功能细节 :
(5 Z )-7-Oxozeaenol is a resorcyclic lactone of fungal origin that acts as a potent and selective transforming growth factor- -activated kinase 1 (TAK1) mitogen-activated protein kinase kinase kinase (MAPKKK) inhibitor (IC50 = 8 nM). Displays 33-fold and 62-fold selectivity over MEKK1 and MEKK4 respectively. Inhibits IL-1-induced activation of NF- B (IC50 = 83 nM) and JNK/p38. Inhibits production of inflammatory mediators, and sensitizes cells to TRAIL- and TNF- -induced apoptosis in vitro .
extended description :
Potent and selective TAK1 MAPKKK inhibitor
化学品名文本 :
(3S,5Z,8S,9S,11E)-3,4,9,10-tetrahydro-8,9,16-trihydroxy-14-methoxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione
配方 :
C 19 H 22 O 7
配方文本 :
C19H22O7
cas num :
253863-19-3
美元 :
222美元
产品细节 :
Potent and selective TAK1 MAPKKK inhibitor
储存 :
Desiccate at -20°C
更多信息或购买 :
公司信息
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
公司总部: 英国