产品简要
公司名称 :
Tocris Bioscience
产品类型 :
化学品
产品名称 :
GSK 690693
目录 :
4144/10
规格 :
10毫克
价格 :
384美元
更多信息或购买 :
Tocris Bioscience 产品网页
文章摘录数: 3
参考文献
Rogers S, Gahring L. Upregulation of Nicotinic Acetylcholine Receptor alph4+beta2 through a Ligand-Independent PI3Kbeta Mechanism That Is Enhanced by TNFalpha and the Jak2/p38Mapk Pathways. PLoS ONE. 2015;10:e0143319 pubmed 出版商
Sokołowska P, Urbańska A, Biegańska K, Wagner W, Ciszewski W, Namiecinska M, et al. Orexins protect neuronal cell cultures against hypoxic stress: an involvement of Akt signaling. J Mol Neurosci. 2014;52:48-55 pubmed 出版商
Khuituan P, Teerapornpuntakit J, Wongdee K, Suntornsaratoon P, Konthapakdee N, Sangsaksri J, et al. Fibroblast growth factor-23 abolishes 1,25-dihydroxyvitamin D?-enhanced duodenal calcium transport in male mice. Am J Physiol Endocrinol Metab. 2012;302:E903-13 pubmed 出版商
产品信息
品牌 :
Tocris
master code :
4144
SKU号 :
4144/10
rank :
0.061
产品名称 :
GSK 690693
描述 :
Akt kinase inhibitor. Antitumor
靶标 :
Akt (Protein Kinase B) Inhibitors
类别 :
Small Molecules
sizes available :
10毫克
网址印刷 :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
功能细节 :
GSK 690693 is an ATP-competitive pan-Akt kinase inhibitor (IC50 values are 2, 13 and 9 nM of Akt1, 2 and 3 respectively). Also exhibits some inhibition for AMPK, PKA and PAK and PKC isoforms (IC50 100 nM). Displays antiproliferative and apoptotic effects in tumor cell lines.
extended description :
Akt kinase inhibitor. Antitumor
化学品名文本 :
4-[2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-3-piperidinylmethoxy)-1H-imidazo[4,5-c]pyridin-4-yl]-2-methyl-3-butyn-2-ol
配方 :
C 21 H 27 N 7 O 3
配方文本 :
C21H27N7O3
cas num :
937174-76-0
美元 :
384美元
产品细节 :
Akt kinase inhibitor. Antitumor
储存 :
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
更多信息或购买 :
Tocris Bioscience 产品网页
公司信息
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
公司总部: 英国