产品简要
公司名称 :
Tocris Bioscience
产品类型 :
化学品
产品名称 :
MDL 100907
目录 :
4173/10
规格 :
10 mg (also 50 mg)
价格 :
332美元
更多信息或购买 :
Tocris Bioscience 产品网页
文章摘录数: 8
参考文献
Yuede C, Wallace C, Davis T, Gardiner W, Hettinger J, Edwards H, et al. Pimavanserin, a 5HT2A receptor inverse agonist, rapidly suppresses Aβ production and related pathology in a mouse model of Alzheimer's disease. J Neurochem. 2021;156:658-673 pubmed 出版商
Zhou W, Jin Y, Meng Q, Zhu X, Bai T, Tian Y, et al. A neural circuit for comorbid depressive symptoms in chronic pain. Nat Neurosci. 2019;22:1649-1658 pubmed 出版商
Alharris E, Singh N, Nagarkatti P, Nagarkatti M. Role of miRNA in the regulation of cannabidiol-mediated apoptosis in neuroblastoma cells. Oncotarget. 2019;10:45-59 pubmed 出版商
Athilingam J, Ben Shalom R, Keeshen C, Sohal V, Bender K. Serotonin enhances excitability and gamma frequency temporal integration in mouse prefrontal fast-spiking interneurons. elife. 2017;6: pubmed 出版商
Moutkine I, Quentin E, Guiard B, Maroteaux L, Doly S. Heterodimers of serotonin receptor subtypes 2 are driven by 5-HT2C protomers. J Biol Chem. 2017;292:6352-6368 pubmed 出版商
Grønli J, Clegern W, Schmidt M, Nemri R, Rempe M, Gallitano A, et al. Sleep Homeostatic and Waking Behavioral Phenotypes in Egr3-Deficient Mice Associated with Serotonin Receptor 5-HT2 Deficits. Sleep. 2016;39:2189-2199 pubmed 出版商
Bocchio M, Fucsina G, Oikonomidis L, McHugh S, Bannerman D, Sharp T, et al. Increased Serotonin Transporter Expression Reduces Fear and Recruitment of Parvalbumin Interneurons of the Amygdala. Neuropsychopharmacology. 2015;40:3015-26 pubmed 出版商
Daftary S, Calderon G, Rios M. Essential role of brain-derived neurotrophic factor in the regulation of serotonin transmission in the basolateral amygdala. Neuroscience. 2012;224:125-34 pubmed 出版商
产品信息
品牌 :
Tocris
master code :
4173
SKU号 :
4173/10
rank :
0.061
产品名称 :
MDL 100907
描述 :
Potent and selective 5-HT2A antagonist
靶标 :
5-HT2A Receptor Antagonists
类别 :
Small Molecules
sizes available :
10 mg (also 50 mg)
网址印刷 :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
功能细节 :
MDL 100907 is a potent and selective 5-HT2A receptor antagonist (Ki = 0.36 nM, IC50 = 3.3-5.1 nM). MDL 100907 exhibits > 80-fold selectivity for 5-HT2A receptors over other serotonergic receptor subtypes. MDL 100907 is neuroprotective; protects cultured dopaminergic neurons from MPP+ induced toxicity. Antipsychotic agent in vivo .
extended description :
Potent and selective 5-HT2A antagonist
化学品名文本 :
(R)-(+)- -(2,3-Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperinemethanol
配方 :
C 22 H 28 FNO 3
配方文本 :
C22H28FNO3
cas num :
139290-65-6
美元 :
332美元
产品细节 :
Potent and selective 5-HT2A antagonist
别名 :
Volinanserin
储存 :
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
更多信息或购买 :
Tocris Bioscience 产品网页
公司信息
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
公司总部: 英国