产品简要
公司名称 :
Tocris Bioscience
产品类型 :
化学品
产品名称 :
Ro 3306
目录 :
4181/10
规格 :
10 mg (also 50 mg)
价格 :
263美元
更多信息或购买 :
Tocris Bioscience 产品网页
文章摘录数: 10
参考文献
Smith R, Cordeiro M, Davey N, Vallardi G, Ciliberto A, Gross F, et al. PP1 and PP2A Use Opposite Phospho-dependencies to Control Distinct Processes at the Kinetochore. Cell Rep. 2019;28:2206-2219.e8 pubmed 出版商
Liccardi G, Ramos Garcia L, Tenev T, Annibaldi A, Legrand A, Robertson D, et al. RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation. Mol Cell. 2019;73:413-428.e7 pubmed 出版商
Meyer S, Dunn M, Vidler D, Porter A, Blain P, Jowsey P. Phosphorylation of MCPH1 isoforms during mitosis followed by isoform-specific degradation by APC/C-CDH1. FASEB J. 2019;33:2796-2808 pubmed 出版商
Sacristan C, Ahmad M, Keller J, Fermie J, Groenewold V, Tromer E, et al. Dynamic kinetochore size regulation promotes microtubule capture and chromosome biorientation in mitosis. Nat Cell Biol. 2018;20:800-810 pubmed 出版商
Karki M, Keyhaninejad N, Shuster C. Precocious centriole disengagement and centrosome fragmentation induced by mitotic delay. Nat Commun. 2017;8:15803 pubmed 出版商
Ramkumar P, Lee C, Moradian A, Sweredoski M, Hess S, Sharrocks A, et al. JNK-associated Leucine Zipper Protein Functions as a Docking Platform for Polo-like Kinase 1 and Regulation of the Associating Transcription Factor Forkhead Box Protein K1. J Biol Chem. 2015;290:29617-28 pubmed 出版商
Shukla A, Kong D, Sharma M, Magidson V, Loncarek J. Plk1 relieves centriole block to reduplication by promoting daughter centriole maturation. Nat Commun. 2015;6:8077 pubmed 出版商
Silva V, Plooster M, Leung J, Cassimeris L. A delay prior to mitotic entry triggers caspase 8-dependent cell death in p53-deficient Hela and HCT-116 cells. Cell Cycle. 2015;14:1070-81 pubmed 出版商
Goonesekere N, Wang X, Ludwig L, Guda C. A meta analysis of pancreatic microarray datasets yields new targets as cancer genes and biomarkers. PLoS ONE. 2014;9:e93046 pubmed 出版商
Rossi M, Duan S, Jeong Y, Horn M, Saraf A, Florens L, et al. Regulation of the CRL4(Cdt2) ubiquitin ligase and cell-cycle exit by the SCF(Fbxo11) ubiquitin ligase. Mol Cell. 2013;49:1159-66 pubmed 出版商
产品信息
品牌 :
Tocris
master code :
4181
SKU号 :
4181/10
rank :
0.061
产品名称 :
Ro 3306
描述 :
Cdk1 inhibitor
靶标 :
Cyclin-dependent Kinase Inhibitors
类别 :
Small Molecules
sizes available :
10 mg (also 50 mg)
网址印刷 :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
功能细节 :
Ro 3306 is an ATP-competitive cyclin-dependent kinase 1 (cdk1) inhibitor (Ki values range from 35 to 240 nM depending on cdk1 binding partner). Also reported to inhibit other cdks (Ki values are 0.89-1.32, 0.03 and >2 M for cdk2, cdk3 and cdk4, respectively). Induces G2/M phase cell cycle arrest and apoptosis. Downregulates the expression of antiapoptotic proteins such as Bcl-2 and survivin and enhances downstream p53 signaling in acute myeloid leukemia (AML). RO 3306 also improves homology-directed repair (HDR) -mediated gene editing in hematopoietic stem and progenitor cells.
extended description :
Cdk1 inhibitor
化学品名文本 :
5-(6-Quinolinylmethylene)-2-[(2-thienylmethyl)amino]-4(5H)-thiazolone
配方 :
C 18 H 13 N 3 OS 2
配方文本 :
C18H13N3OS2
cas num :
872573-93-8
美元 :
263美元
产品细节 :
Cdk1 inhibitor
储存 :
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
更多信息或购买 :
Tocris Bioscience 产品网页
公司信息
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
公司总部: 英国