产品简要
公司名称 :
Tocris Bioscience
产品类型 :
化学品
产品名称 :
Bosutinib
目录 :
4361/10
规格 :
10 mg (also 50 mg)
价格 :
323美元
更多信息或购买 :
Tocris Bioscience 产品网页
文章摘录数: 2
参考文献
Levinson N, Boxer S. A conserved water-mediated hydrogen bond network defines bosutinib's kinase selectivity. Nat Chem Biol. 2014;10:127-32 pubmed 出版商
Levinson N, Boxer S. Structural and spectroscopic analysis of the kinase inhibitor bosutinib and an isomer of bosutinib binding to the Abl tyrosine kinase domain. PLoS ONE. 2012;7:e29828 pubmed 出版商
产品信息
品牌 :
Tocris
master code :
4361
SKU号 :
4361/10
rank :
0.061
产品名称 :
Bosutinib
描述 :
Dual Src-Abl inhibitor; antiproliferative
靶标 :
Src Family Kinase Inhibitors
类别 :
Small Molecules
sizes available :
10 mg (also 50 mg)
网址印刷 :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
功能细节 :
Bosutinib is a dual inhibitor of Abl and Src kinases (IC50 = 1.2 nM for Src in an enzymatic assay). Displays antiproliferative activity against chronic myelogenous leukemia (CML) cells and decreases the motility and invasion of breast cancer cell lines. Also exhibits potent antiproliferative activity in anchorage-independent, Src-transformed rat fibroblasts (IC50 = 100 nM). Displays selectivity for Src over non-Src family kinases such as growth factor receptor tyrosine kinases.
extended description :
Dual Src-Abl inhibitor; antiproliferative
化学品名文本 :
4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile
配方 :
C 26 H 29 Cl 2 N 5 O 3
配方文本 :
C26H29Cl2N5O3
cas num :
380843-75-4
美元 :
323美元
产品细节 :
Dual Src-Abl inhibitor; antiproliferative
别名 :
滑雪-606
储存 :
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
更多信息或购买 :
Tocris Bioscience 产品网页
公司信息
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
公司总部: 英国