化学品

SMBA 1

5314/10

10 mg (also 50 mg)

230美元

5314

5314/10

0.071

SMBA 1

High affinity and selective activator of Bax

Bcl-2 Family Inhibitors

Small Molecules

10 mg (also 50 mg)

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SMBA 1 is a high affinity and selective activator of Bax (Ki = 43.3 nM). Binds to the S184 binding pocket to block Bax phosphorylation. Does not bind to other Bcl-2 family members, including Bcl-2, Bak and Bid. Facilitates Bax insertion into the mitochondrial membrane and promotes Bax-dependent cytochrome c release. Induces apoptosis in lung cancer cell lines expressing high levels of Bax selectively over normal cells expressing low levels of Bax. Represses tumor growth of A549 lung cancer xenografts in mice.

High affinity and selective activator of Bax

2-[(2-Nitro-9H-fluorene-9-ylidene)methyl]phenol

C 20 H 13 NO 3

C20H13NO3

906440-37-7

230美元

High affinity and selective activator of Bax

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.