产品简要
信息索取 :
公司名称 :
Toronto BioScience
产品类型 :
抗体
产品名称 :
小鼠FGF-21多克隆抗体
目录 :
12180
规格 :
100微克
价格 :
233美元
克隆性 :
多克隆
宿主 :
兔
反应物种 :
小鼠
应用 :
免疫印迹, 酶联免疫吸附测定
更多信息或购买 :
Toronto BioScience 产品网页
文章摘录数: 4
已发表的文献中的应用方法／种属／稀释度参考文献
Zhen E, Jin Z, Ackermann B, Thomas M, Gutierrez J. Circulating FGF21 proteolytic processing mediated by fibroblast activation protein. Biochem J. 2016;473:605-14 pubmed 出版商
Zhang W, Chu S, Ding W, Wang F. Serum Level of Fibroblast Growth Factor 21 Is Independently Associated with Acute Myocardial Infarction. PLoS ONE. 2015;10:e0129791 pubmed 出版商
Samms R, Murphy M, Fowler M, Cooper S, Emmerson P, Coskun T, et al. Dual effects of fibroblast growth factor 21 on hepatic energy metabolism. J Endocrinol. 2015;227:37-47 pubmed 出版商
Ribas F, Villarroya J, Hondares E, Giralt M, Villarroya F. FGF21 expression and release in muscle cells: involvement of MyoD and regulation by mitochondria-driven signalling. Biochem J. 2014;463:191-9 pubmed 出版商
产品信息
目录代码 :
12180
产品名称 :
小鼠FGF-21多克隆抗体
宿主物种 :
兔
克隆性 :
多克隆
共轭 :
纯化
产品类型 :
抗体
规格 :
100微克
标价(美元) :
233美元
Pubmed号列表 :
26635356, 26294388, 26091256, 25055037
抗体亚型 :
兔IgG
产品描述 :
This affinity purifed rabbit polyclonal antibody can detect circular mouse fibroblast growth factor 21 (FGF-21) by ELISA and by Western Blot.
物种摘要 :
小鼠特异性
背景 :
Fibroblast growth factor 21(FGF-21) is a novel protein that has been implicated in the regulation of lipid and glucose metabolism under fasting and ketotic conditions1,2. In murine models, FGF-21 is predominantly expressed in liver, but it also expressed in adipose tissue and pancreatic β- cells3,4. FGF-21 stimulates glucose uptake in adipocytes. It also protects animals from diet-induced obesity when overexpressed in transgenic mice and lowers blood glucose and triglyceride levels when administered to diabetic rodents5. When administered daily for 6 weeks to diabetic rhesus monkeys, FGF-21 caused a dramatic decline in fasting plasma glucose, fructosamine, triglycerides, insulin, and glucagon6. Furthermore, elevated plasma FGF-21 concentrations in humans appear to be related to the presence of hepatic and peripheral insulin resistance7.
别名 :
成纤维细胞生长因子21, FGF-21
免疫原 :
重组全长小鼠FGF-21在大肠杆菌中表达
特异性 :
小鼠
缓冲液 :
溶液在PBS
用途 :
ELISA - This antibody can be used at 2 μg/mL with the appropriate secondary reagents to detect mouse FGF-21. Western blot - This antibody can be used at 0.2μg/mL~0.5μg/mL with the appropriate secondary reagents to detect mouse FGF-21.
应用摘要 :
ELISA - This antibody can be used at 2 μg/mL with the appropriate secondary reagents to detect mouse FGF-21. Western blot - This antibody can be used at 0.2μg/mL~0.5μg/mL with the appropriate secondary reagents to detect mouse FGF-21.
储存 :
Store at –20°C. For long-term storage, aliquot and freeze at -70°C. Avoid repeated freeze/defrost cycles.
一般参考 :
[1] Kharitonenkov A, et al. (2005) J Clin Invest; 115: 1627– 1635. [2] Badman MK, Pissios P, et al. (2007) Cell Metab; 5: 426– 437. [3] Nishimura T, et al. (2000) Biochim Biophys Acta; 1492: 203– 206. [4] Kurosu H, et al. (2007) J Biol Chem; 282: 26687– 26695. [5] Kharitonenkov A, et al. (2005) J. Clin. Invest; 115: 1627–35. [6] Kharitonenkov, et al. (2007) Endocrinology; 148:774-81. [7] Chavez AO, et al. (2009) Diabetes Care; 32:1542-6.
产品引用 :
Diabetes. 2014 Dec;63(12):4064-75.
更多信息或购买 :
Toronto BioScience 产品网页
公司信息
Toronto BioScience
info@torontobioscience.com
www.torontobioscience.com
公司总部: 加拿大