产品简要
信息索取 :
公司名称 :
Toronto BioScience
产品类型 :
抗体
产品名称 :
脂联素(人类), 小鼠单克隆Ha7
目录 :
21011
规格 :
100微克
价格 :
194美元
克隆性 :
单克隆
宿主 :
小鼠
反应物种 :
人类
更多信息或购买 :
文章摘录数: 5
| 已发表的文献中的应用方法／种属／稀释度 | 参考文献 |
|---|---|
产品信息
目录代码 :
21011
产品名称 :
脂联素(人类), 小鼠单克隆Ha7
宿主物种 :
小鼠
克隆性 :
单克隆
共轭 :
纯化
产品类型 :
抗体
规格 :
100微克
标价(美元) :
194美元
Pubmed号列表 :
26417088, 26166748, 25915851, 25961840, 25071026
克隆 :
Ha7
抗体亚型 :
小鼠IgG
产品描述 :
This affinity purified mouse monoclonal antibody can be used as a detection antibody in a human adiponectin ELISA in combination with monoclonal anti-human adiponectin antibody (Cat. No.: 21011).
交叉活性 :
Not yet tested in other species.
物种摘要 :
人类特异性
背景 :
As described in the product data sheet, adiponectin, also known as apM1, Acrp30, GBP28 and adipoQ, is a circulating hormone predominantly produced from adipose tissue. Many pharmacological studies demonstrated that this protein possesses potent anti-diabetic, anti-atherogenic and anti-inflammatory functions. Supplement of adiponectin protein can decrease blood glucose, improve insulin sensitivity, alleviate fatty liver and prevent atherosclerosis. The protein is posttranslationally modified by hydroxylation and glycosylation, and forms three different oligomeric complexes in the circulation. Many clinical studies demonstrated that plasma adiponectin is an useful biomarker for metabolic syndrome, nonalcoholic steatohepatitis and certain type of cancers. Decreased circulating levels of plasma adiponectin (hypoadiponectinaemia) are associated with increased body mass index (BMI), decreased insulin sensitivity, less favourable plasma lipid profiles, increased levels of inflammatory markers and increased risk for the development of type 2 diabetes, hypertension, and coronary heart diseases. Low adiponectin concentrations were found to be predictive of a future reduction in insulin sensitivity and cardiovascular disorders. Administration of the anti-diabetic drugs thiazolidinediones (TZDs) raises circulating adiponectin levels. In addition, low plasma adiponectin levels are also associated with nonalcoholic steatohepatitis (NASH) and certain types of cancers.
别名 :
Adiponectin is also known as apM1, Acrp30, GBP28 and adipoQ.
免疫原 :
HEK-293 derived recombinant human adiponectin (Cat. No. 41013)
特异性 :
人类
缓冲液 :
溶液在PBS
用途 :
This antibody can be used as a detection antibody in a human adiponectin ELISA in combination with monoclonal anti-human adiponectin antibody (Cat. No.: 21011)
应用摘要 :
This antibody can be used as a detection antibody in a human adiponectin ELISA in combination with monoclonal anti-human adiponectin antibody (Cat. No.: 21011)
储存 :
存放在–20°C
一般参考 :
[1] Trujillo ME, Scherer PE. (2005) J Intern Med. 257:167-175. [2] Berg AH. et al. (2001) Nat Med. 7:947-953. [3] Yamauchi T. et al.(2001) Nat Med. 7:941-946. [4] Xu A. et al. (2003) J Clin Invest, 112:91-100. [5] Okamoto Y. et al. (2002) Circulation. 106:2767-2770. [6] Wang Y. et al. (2002) J Biol Chem. 277:19521-19529. [7] Xu A. et al. (2005) J Biol Chem. 280:18073-18080. [8] Maeda N. et al. (2001) Diabetes. 50:2094-2099.
产品引用 :
Journal American Heart Association 2013 [2(1):e004176]
更多信息或购买 :
公司信息
Toronto BioScience