产品简要
公司名称 :
Toronto BioScience
产品类型 :
抗体
产品名称 :
视黄醇结合蛋白4(人类), 小鼠单克隆1A2
目录 :
21061
规格 :
100微克
价格 :
194美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
nonconjugated
克隆名称 :
1A2
反应物种 :
人类
更多信息或购买 :
文章摘录数: 4
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产品信息
目录代码 :
21061
产品名称 :
视黄醇结合蛋白4(人类), 小鼠单克隆1A2
宿主物种 :
小鼠
克隆性 :
单克隆
共轭 :
纯化
产品类型 :
抗体
规格 :
100微克
标价(美元) :
194美元
Pubmed号列表 :
19766271, 19709697, 18796616, 19147488
克隆 :
1A2
抗体亚型 :
小鼠IgG
产品描述 :
This mouse monoclonal antibody can be used as a detection antibody in a human retinol binding protein 4 ELISA in combination with monoclonal anti-human retinol binding protein 4 antibody (Cat. No.: 21060)
物种摘要 :
人类特异性
背景 :
Retinol binding protein 4 (RBP4), originally known as a specific transport of retinol in blood, is also a novel inflammatory and insulin resistance marker. Serum RBP4 levels are elevated in insulin-resistant mice and humans with obesity and type 2 diabetes. Animal experiments found that increased secretion of RBP4 might reduces insulin-dependent glucose uptake by muscle tissue by reducing the activity of PI(3)K (phosphoinositide 3-kinase), and increased hepatic glucose output by increasing the expression of the enzyme PEPCK2. Studies suggested that elevated serum RBP4 was associated with components of the metabolic syndrome, including increased body-mass index, waist-to-hip ratio, serum triglyceride levels, and systolic blood pressure and decreased high- density lipoprotein cholesterol levels. Furthermore, circulating RBP4 concentrations were associated with subclinical cardiovascular disease, which imply that RBP4 could be involved in the development of atherosclerosis.
别名 :
Retinol binding protein (RBP4) is also known as 4RDCCAS and MCOPCB10
免疫原 :
E. coli derived recombinant human RBP4 (Cat. No. 41060)
特异性 :
人类
缓冲液 :
溶液在PBS
用途 :
ELISA - detection antibody
应用摘要 :
This antibody can be used as a detection antibody in a human retinol binding protein 4 ELISA in combination with monoclonal anti-human retinol binding protein 4 antibody (Cat. No.: 21060)
储存 :
存放在–20°C
一般参考 :
1.The metabolic role of retinol binding protein 4: an update. Christou GA, Tselepis AD, Kiortsis DN. Horm Metab Res. 2012 44(1):6-14.
2. RBP4: a controversial adipokine. Kotnik P, Fischer-Posovszky P, Wabitsch M. Eur J Endocrinol. 2011 Nov;165(5):703-11
产品引用 :
Journal of Clinical Endocrinology & Metabolism 2012 [97(12):4701-8]; PLoS One 2013 [8(6):e66607]; PLoS One. 2014 May 6;9(5):e96489;
更多信息或购买 :
公司信息
Toronto BioScience