抗体

APP (Amyloid beta A4 Protein, ABPP, APPI, Alzheimer Disease Amyloid Protein, Cerebral Vascular Amyloid Peptide, CVAP, PreA4, Protease Nexin-II, PN-II, A4, AD1)

029722

100微克

493美元

多克隆

domestic rabbit

未共轭

APP (Amyloid beta A4 Protein, ABPP, APPI, Alzheimer Disease Amyloid Protein, Cerebral Vascular Amyloid Peptide, CVAP, PreA4, Protease Nexin-II, PN-II, A4, AD1)

兔

多克隆抗体

抗体

100微克

493美元

IgG

Accumulation of the amyloid-b peptide (Ab) in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. The b-amyloid protein precursor (APP) is cleaved by b-secretase, producing a soluble derivative of the protein and a membrane anchored 99aa carboxy-terminal fragment (C99). The C99 fragment serves as substrate for g-secretase to generate the 4kD amyloid-b peptide, which is deposited in the brains of all suffers of Alzheimer's disease. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1-4ug/ml Immunohistochemistry: 2-10ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Ch Hu Mk Mo Rt

Synthetic peptide corresponding to aa737-751 from human amyloid A4 protein precursor (APP) or aa85-99 of the C99 fragment generated by b-secretase cleavage.

Recognizes human APP. Species Crossreactivity: chicken, monkey, mouse and rat.

经免疫亲和层析纯化

以溶解在PBS液体方式提供, pH值7.2, 1% BSA, 0.02% 硫柳汞, 50% 甘油

~0.5毫克/毫升

Product Type: Pab Isotype: IgG Host: rabbit Source: human Concentration: ~0.5mg/ml Form: Supplied as a liquid in PBS, pH 7.2, 1% BSA, 0.02% thimerosal, 50% glycerol. Purity: Purified by immunoaffinity chromatography. Immunogen: Synthetic peptide corresponding to aa737-751 from human amyloid A4 protein precursor (APP) or aa85-99 of the C99 fragment generated by b-secretase cleavage. Specificity: Recognizes human APP. Species Crossreactivity: chicken, monkey, mouse and rat. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

免疫组化免疫印迹

-20°C