AKT1(蛋白激酶B, RAC甲丝氨酸/苏氨酸蛋白激酶)

产品简要

公司名称 :

US Biological

产品类型 :

抗体

产品名称 :

AKT1(蛋白激酶B, RAC甲丝氨酸/苏氨酸蛋白激酶)

029942

规格 :

100微升

价格 :

473美元

克隆性 :

单克隆

宿主 :

小鼠

共轭标签 :

未共轭

克隆名称 :

13B20

反应物种 :

人类

更多信息或购买 :

US Biological 产品网页

产品信息

目录号 :

029942

Product wo Prefix :

AKT1(蛋白激酶B, RAC甲丝氨酸/苏氨酸蛋白激酶)

宿主 :

小鼠

产品类型 :

单克隆抗体

类别 :

抗体

尺寸1 :

100微升

Size1 List :

473美元

克隆#USB :

13B20

抗体亚型 :

IgG1

Desc1 :

The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Multiple alternatively spliced transcript variants have been found for this gene. Applications: Western Bloting: 1:500-1:2000. ELISA: Suggested dilution 1:10000. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Calc Crossreactivity :

Hu Mk Mo

又名 :

AKT;PKB;RAC;PRKBA;MGC99656;PKB-甲;RAC-甲;AKT1

免疫原 :

纯化重组片段对应于人AKT1在大肠杆菌中表达

特异性 :

Human, Mouse, Monkey

纯度 :

腹水

形式 :

Ascites fluid, 0.03% sodium azide.

浓度 :

未确定

Desc2 :

Product Type: Mab Isotype: IgG1 Clone No: 13B20 Host: mouse Source: human Concentration: Not determined Form: Ascites fluid, 0.03% sodium azide. Purity: Ascites Immunogen: Purified recombinant fragment of human AKT1 expressed in E. coli. Specificity: Human, Mouse, Monkey Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

E免疫印迹

储存温度 :

-20°C

参考文献 :

1. J Cell Physiol. 2010 Oct;225(1):168-73. 2. Mol Cell Biol. 1995 Apr;15(4):2304-10. 3. EMBO J. 1997 Sep 1;16(17):5445-54.

更多信息或购买 :

US Biological 产品网页

公司信息