ATM (Ataxia telangiectasia mutated) | US Biological 029974 产品信息

产品简要

公司名称 :

US Biological

产品类型 :

抗体

产品名称 :

ATM (Ataxia telangiectasia mutated)

029974

规格 :

100微升

价格 :

502美元

克隆性 :

单克隆

宿主 :

小鼠

共轭标签 :

未共轭

克隆名称 :

13B52

反应物种 :

人类

更多信息或购买 :

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产品信息

目录号 :

029974

Product wo Prefix :

ATM (Ataxia telangiectasia mutated)

宿主 :

小鼠

产品类型 :

单克隆抗体

类别 :

抗体

尺寸1 :

100微升

Size1 List :

502美元

克隆#USB :

13B52

抗体亚型 :

IgG1

Desc1 :

The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.Tissue specificity: Found in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain, heart, spleen, thymus, testis, ovary, small intestine, colon and leukocytes. Applications: Western Bloting: 1:500-1:2000. ELISA: Suggested dilution 1:10000. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Calc Crossreactivity :

又名 :

AT1;ATA;ATC;ATD;ATE;ATDC;TEL1;TELO1;MGC74674;DKFZp781A0353;毛细血管扩张性共济失调症突变蛋白

免疫原 :

纯化重组片段对应于人毛细血管扩张性共济失调症突变蛋白在大肠杆菌中表达

特异性 :

人类

纯度 :

腹水

形式 :

Ascites fluid, 0.03% sodium azide.

浓度 :

未确定

Desc2 :

Product Type: Mab Isotype: IgG1 Clone No: 13B52 Host: mouse Source: human Concentration: Not determined Form: Ascites fluid, 0.03% sodium azide. Purity: Ascites Immunogen: Purified recombinant fragment of human ATM expressed in E. coli. Specificity: Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

E免疫印迹

储存温度 :

-20°C

参考文献 :

1. Am J Hum Genet. 2008 Aug;83(2):243-53. 2. Mol Cell. 2008 Jul 25;31(2):167-77.

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公司信息