抗体

CDH1 (Cadherin 1, type 1, E-cadherin (epithelial), E-cadherin, Epithelial cadherin, LCAM, UVO, Uvomorulin)

030074

100微升

473美元

单克隆

小鼠

未共轭

13B152

CDH1 (Cadherin 1, type 1, E-cadherin (epithelial), E-cadherin, Epithelial cadherin, LCAM, UVO, Uvomorulin)

小鼠

单克隆抗体

抗体

100微升

473美元

13B152

IgG1

E-Cadherin is a 120kD transmembrane glycoprotein that is localized in the adherens junctions of epithelial cells. There, it interacts with the cytoskeleton through the associated cytoplasmic catenin proteins. In addition to being a calcium-dependent adhesion molecule, E-Cadherin is also a critical regulator of epithelial junction formation. Its association with catenins is necessary for cell-cell adhesion. These E-cadherin/catenin complexes associate with corical actin bundles at both the zonula adherens and the lateral adhesion plaques. Tyrosine phosphorylation can disrupt these complexes, leading to changes in cell adhesion properties. E-Cadherin expression is often down-regulated in highly invasive, poorly differentiated carcinomas. Increased expression of E-Cadherin in these cells reduces invasiveness. Thus, loss of expression or function of E-Cadherin appears to be an important step in tumorigenic progression.Tissue specificity: Non-neural epithelial tissues. Applications: Western Bloting: 1:500-1:2000. Immunohistochemistry: 1:200-1:1000. Flow cytometry: 1:200-1:400. ELISA: Suggested dilution 1:10000. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Hu Mk Mo

UVO; CDHE; ECAD; LCAM; Arc-1; CD324; CDH1

纯化重组片段对应于人CDH1在大肠杆菌中表达

Human, Mouse, Monkey

腹水

Ascites fluid, 0.03% sodium azide.

未确定

Product Type: Mab Isotype: IgG1 Clone No: 13B152 Host: mouse Source: human Concentration: Not determined Form: Ascites fluid, 0.03% sodium azide. Purity: Ascites Immunogen: Purified recombinant fragment of human CDH1 expressed in E. coli. Specificity: Human, Mouse, Monkey Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

E FC免疫组化免疫印迹

-20°C

1. Nat Genet. 2009 Dec;41(12):1330-4. 2. Zhonghua Zhong Liu Za Zhi. 2009 Jul;31(7):515-9. 3. J Biol Chem. 2010 Feb 26;285(9):6658-69.