ERBB3 | US Biological 030189 产品信息

产品简要

公司名称 :

US Biological

产品类型 :

抗体

产品名称 :

ERBB3

030189

规格 :

100微升

价格 :

473美元

克隆性 :

单克隆

宿主 :

小鼠

共轭标签 :

未共轭

克隆名称 :

13B267

反应物种 :

人类

更多信息或购买 :

US Biological 产品网页

产品信息

目录号 :

030189

Product wo Prefix :

ERBB3

宿主 :

小鼠

产品类型 :

单克隆抗体

类别 :

抗体

尺寸1 :

100微升

Size1 List :

473美元

克隆#USB :

13B267

抗体亚型 :

IgG1

Desc1 :

ERBB3: v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian). This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. Applications: Western Bloting: 1:500-1:2000. Immunohistochemistry: 1:200-1:1000. ELISA: Suggested dilution 1:10000. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Calc Crossreactivity :

又名 :

HER3;LCCS2

免疫原 :

Purified recombinant fragment of ERBB3 (aa1175-1275) expressed in E. coli.

特异性 :

人类

纯度 :

腹水

形式 :

Ascites fluid, 0.03% sodium azide.

浓度 :

未确定

Desc2 :

Product Type: Mab Isotype: IgG1 Clone No: 13B267 Host: mouse Source: human Concentration: Not determined Form: Ascites fluid, 0.03% sodium azide. Purity: Ascites Immunogen: Purified recombinant fragment of ERBB3 (aa1175-1275) expressed in E. coli. Specificity: Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

E免疫组化免疫印迹

储存温度 :

-20°C

参考文献 :

1. Cancer Sci. 2007 Sep;98(9):1498-503. 2. Breast Cancer Res. 2008;10(1):R2.

更多信息或购买 :

US Biological 产品网页

公司信息