产品简要
公司名称 :
US Biological
产品类型 :
抗体
产品名称 :
肿瘤坏死因子受体超家族成员6
目录 :
030214
规格 :
100微升
价格 :
502美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
13B292
反应物种 :
人类
更多信息或购买 :
产品信息
目录号 :
030214
Product wo Prefix :
肿瘤坏死因子受体超家族成员6
宿主 :
小鼠
产品类型 :
单克隆抗体
类别 :
抗体
尺寸1 :
100微升
Size1 List :
502美元
克隆#USB :
13B292
抗体亚型 :
IgG1
Desc1 :
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. Applications: Western Bloting: 1:500-1:2000. Flow cytometry: 1:200-1:400. ELISA: Suggested dilution 1:10000. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Calc Crossreactivity :
Hu
又名 :
APT1;CD95;FAS1;ApoE基因-1;FASTM;ALPS1A;TNFRSF6
免疫原 :
纯化重组片段对应于人肿瘤坏死因子受体超家族成员6在大肠杆菌中表达
特异性 :
人类
纯度 :
纯化
形式 :
Purified antibody in PBS with 0.05% sodium azide and 0.5% protein stabilizer.
浓度 :
~1毫克/毫升
Desc2 :
Product Type: Mab Isotype: IgG1 Clone No: 13B292 Host: mouse Source: human Concentration: ~1mg/ml Form: Purified antibody in PBS with 0.05% sodium azide and 0.5% protein stabilizer. Purity: Purified Immunogen: Purified recombinant fragment of human FAS expressed in E. coli. Specificity: human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Calc Applications Abbrev :
E FC免疫印迹
储存温度 :
-20°C
参考文献 :
Int J Surg Pathol. 2010 Dec;18(6):493-8 Am J Hum Genet. 2009 Nov;85(5):628-42
更多信息或购买 :
公司信息
US Biological
4 Technology Way
Salem, MA01970
tech@usbio.net
https://www.usbio.net
800-520-3011 781-639-5092
公司总部: 美国
United States Biological是生命科学领域的知名品牌,致力于用真实、有价值的个性化采购经验降低研究用成本。