抗体

FGFR4(成纤维细胞生长因子受体4)

030225

100微升

473美元

单克隆

小鼠

未共轭

13B303

FGFR4(成纤维细胞生长因子受体4)

小鼠

单克隆抗体

抗体

100微升

473美元

13B303

IgG1

FGFR4: fibroblast growth factor receptor 4. Entrez Protein NP_002002. It is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis. Applications: Western Bloting: 1:500-1:2000. Immunofluorescence: 1:200-1:1000. ELISA: Suggested dilution 1:10000. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Hu

TKF;JTK2;CD334

Purified recombinant extracellular fragment of human FGFR4 fused with hIgGFc tag expressed in HEK293 cell line.

人类

腹水

Ascites fluid, 0.03% sodium azide.

未确定

Product Type: Mab Isotype: IgG1 Clone No: 13B303 Host: mouse Source: human Concentration: Not determined Form: Ascites fluid, 0.03% sodium azide. Purity: Ascites Immunogen: Purified recombinant extracellular fragment of human FGFR4 fused with hIgGFc tag expressed in HEK293 cell line. Specificity: Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

E免疫印迹

-20°C

1. Br J Cancer. 2006 Jun 19;94(12):1879-86. 2. Diabetes. 2007 Oct;56(10):2501-10.