抗体

基质金属蛋白酶2(基质金属蛋白酶-2, MMP2, 基质金属蛋白酶-II, 胶原酶IV, 72kD类型IV胶原酶, 胶原酶类型4甲, CLG4A, CLG4, 72kD明胶酶, 明胶酶a, 明胶酶甲, 明胶酶中性粒细胞 , MONA, TBE-1)

030432

100微克

502美元

单克隆

小鼠

未共轭

13B510

基质金属蛋白酶2(基质金属蛋白酶-2, MMP2, 基质金属蛋白酶-II, 胶原酶IV, 72kD类型IV胶原酶, 胶原酶类型4甲, CLG4A, CLG4, 72kD明胶酶, 明胶酶a, 明胶酶甲, 明胶酶中性粒细胞 , MONA, TBE-1)

小鼠

单克隆抗体

抗体

100微克

502美元

13B510

IgG1

Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that degrade substances within the extracellular matrix. The MMP family includes six different groups of enzymes: collagenases, gelatinases, stromelysins, transmembrane MMPs, matrilysins and others. MMPs are secreted as proenzymes that have to be cleaved in order to be activated. Other MMPs, plasmins as well as other factors activate MMPs. MMPs are thought to play an important role in tissue remodeling associated with various physiological and pathological processes. MMP1 cleaves collagens of types I, II, III, VII and X. MMP1 is thought to play an important role in rheumatoid and osteo-arthritis pathogenesis as mediators of cartilage and bone destruction. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms have been found for this gene. Applications: Western Blot: 1:500-1:2000 ELISA: 1:10000 Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Hu

纯化重组片段对应于人MMP2(AA: 242-396)在大肠杆菌中表达

人类

纯化

Purified antibody in PBS with 0.05% sodium azide and 0.5% protein stabilizer

As reported

Product Type: Mab Isotype: IgG1 Clone No: 13B510 Host: mouse Source: human Concentration: As reported Form: Purified antibody in PBS with 0.05% sodium azide and 0.5% protein stabilizer Purity: Purified Immunogen: Purified recombinant fragment of human MMP2 (AA: 242-396) expressed in E. coli. Specificity: Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

E免疫印迹

-20°C

1.Br J Cancer. 2012 Apr 24;106(9):1495-8. 2.Iran J Immunol. 2011 Jun;8(2):120-6.