产品简要
公司名称 :
US Biological
产品类型 :
抗体
产品名称 :
NF-κB p65 (Nuclear factor NF-kappa-B p65 subunit)
目录 :
030488
规格 :
100微升
价格 :
473美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
13B566
反应物种 :
人类
更多信息或购买 :
产品信息
目录号 :
030488
Product wo Prefix :
NF-κB p65 (Nuclear factor NF-kappa-B p65 subunit)
宿主 :
小鼠
产品类型 :
单克隆抗体
类别 :
抗体
尺寸1 :
100微升
Size1 List :
473美元
克隆#USB :
13B566
抗体亚型 :
IgG1
Desc1 :
Transcription factors of the nuclear factor κ B (NF-κB)/Rel family is a ubiquitously expressed transcription factor that regulates many cytokine and Ig genes. It is involved in immune, inflammatory, viral, and acute phase responses. There are five family members in mammals: RelA (p65), c-Rel, RelB, NF-κB1 (p105/p50) and NF-κB2 (p100/p52). The most studied NF-κB complex consists of the p50 and p65 subunits, both containing a 300 amino acid region with homology to the Rel proto-oncogene product. The p50 subunit binds DNA, whereas the p65 subunit is responsible for the interaction of NF-κB with its inhibitor, IκB. In most cell types, the p50/p65 heterodimer is located within the cytoplasm complexed to IκB. This complex prevents nuclear translocation and activity of NF-κB. In response to stimuli such as cytokines, LPS, and viral infections, IκB is phosphorylated at critical residues. This phosphorylation induces dissociation of the IκB/NF-κB complex, allowing the free heterodimeric NF-κB to form a heterotetramer that translocates to the nucleus. In the nucleus, it binds to the κB site within promoters and enhancers and functions as a transcriptional activator. Applications: Western Bloting: 1:500-1:2000. ELISA: Suggested dilution 1:10000. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Calc Crossreactivity :
Hu Mo
又名 :
NFkappaB p65;p65;NFKB3;RELA
免疫原 :
纯化重组片段对应于人NF-κB p65在大肠杆菌中表达
特异性 :
人类, 小鼠
纯度 :
腹水
形式 :
Ascites fluid, 0.03% sodium azide.
浓度 :
未确定
Desc2 :
Product Type: Mab Isotype: IgG1 Clone No: 13B566 Host: mouse Source: human Concentration: Not determined Form: Ascites fluid, 0.03% sodium azide. Purity: Ascites Immunogen: Purified recombinant fragment of human NF-κB p65 expressed in E. coli. Specificity: Human, Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Calc Applications Abbrev :
E免疫印迹
储存温度 :
-20°C
参考文献 :
1. Nature. 1997 Aug 7;388(6642):548-54. 2. Cell. 1998 Dec 11;95(6):749-58. 3. J Biol Chem. 2000 Jun 16;275(24):18180-7.
更多信息或购买 :
公司信息
US Biological
4 Technology Way
Salem, MA01970
tech@usbio.net
https://www.usbio.net
800-520-3011 781-639-5092
公司总部: 美国
United States Biological是生命科学领域的知名品牌,致力于用真实、有价值的个性化采购经验降低研究用成本。