p16(CDKN2A) | US Biological 030517 产品信息

产品简要

公司名称 :

US Biological

产品类型 :

抗体

产品名称 :

p16(CDKN2A)

030517

规格 :

100微升

价格 :

531美元

克隆性 :

单克隆

宿主 :

小鼠

共轭标签 :

未共轭

克隆名称 :

13B595

反应物种 :

人类

更多信息或购买 :

US Biological 产品网页

产品信息

目录号 :

030517

Product wo Prefix :

p16(CDKN2A)

宿主 :

小鼠

产品类型 :

单克隆抗体

类别 :

抗体

尺寸1 :

100微升

Size1 List :

531美元

克隆#USB :

13B595

抗体亚型 :

IgG1

Desc1 :

The progression of cells through the cell cycle is regulated by a family of protein kinases known as cyclin-dependent kinases (Cdks). The sequential activation of individual members of this family and their consequent phosphorylation of critical substrates promotes orderly progression through the cell cycle. The cyclins function as differentially expressed positive regulators of Cdks. Negative regulators of the cycle include the p53-inducible 21kD WAF1/Cip1 protein designated p21, Kip1 p27 and p16. The complexes formed by Cdk4 and the D-type cyclins have been strongly implicated in the control of cell proliferation during the G1 phase. It has recently been shown that p16 binds to Cdk4 and inhibits the catalytic activity of the Cdk4/cyclin D complex. Moreover, the gene encoding p16 exhibits a high frequency of homozygous deletions and point mutations in established human tumor cell lines. Applications: Western Bloting: 1:500-1:2000. Immunohistochemistry: 1:200-1:1000. ELISA: Suggested dilution 1:10000. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Calc Crossreactivity :

Hu Mo Rt

免疫原 :

Purified recombinant fragment of P16 expressed in E. coli.

特异性 :

Human，Rat，Mouse

纯度 :

腹水

形式 :

Ascites fluid, 0.03% sodium azide.

浓度 :

未确定

Desc2 :

Product Type: Mab Isotype: IgG1 Clone No: 13B595 Host: mouse Source: human Concentration: Not determined Form: Ascites fluid, 0.03% sodium azide. Purity: Ascites Immunogen: Purified recombinant fragment of P16 expressed in E. coli. Specificity: Human，Rat，Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Calc Applications Abbrev :

E免疫组化免疫印迹

储存温度 :

-20°C

参考文献 :

1. Hunter, T. 1993. Cell 75: 839-841. 2. Sherr, C.J. 1993. Cell 73: 1059-1065. 3. El-Deiry, W.S., et al. 1993. Cell 75: 817-825.

更多信息或购买 :

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公司信息