抗体

p16 (ARF, CDK4I, CDKN2, CMM2, Cyclin-dependent kinase 4 inhibitor A, Cyclin-dependent kinase inhibitor 2A, isoform 4, INK4A)

030518

100微升

473美元

单克隆

小鼠

未共轭

13B596

p16 (ARF, CDK4I, CDKN2, CMM2, Cyclin-dependent kinase 4 inhibitor A, Cyclin-dependent kinase inhibitor 2A, isoform 4, INK4A)

小鼠

单克隆抗体

抗体

100微升

473美元

13B596

IgG1

p16 (cyclin-dependent kinase inhibitor 2A, INK4a) is a tumor suppressor protein. It is a specific inhibitor of Cdk 4 / Cdk 6, and a tumor suppressor involved in the pathogenesis of a variety of malignancies. Recent analyses of the p16 INK4a gene revealed homozygous deletions, nonsense, missense, or frameshift mutations in several human cancers. Although the frequency of p16 INK4a abnormalities is higher in tumor derived cell lines than in unselected primary tumors, significant subsets of clinical cases with aberrant p16 INK4a gene have been reported among melanomas, gliomas, esophageal, pancreatic, lung, and urinary bladder carcinomas, and some types of leukemia. Applications: Suitable for use in Western Blot, Immunohistochemistry and ELISA. Other applications have not been tested. Recommended Dilutions: Western Blot: 1:500-1:2000 Immunohistochemistry: 1:200-1:1000 ELISA: 1:10,000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Hu

Purified recombinant fragment of P16 expressed in E. coli.

识别人类p16

纯化

以溶解在PBS液体方式提供, 0.03% 叠氮化钠

~1毫克/毫升

Product Type: Mab Isotype: IgG1 Clone No: 13B596 Host: mouse Source: human Concentration: Not Determined Form: Supplied as a liquid in PBS, 0.03% sodium azide. Purity: Purified Immunogen: Purified recombinant fragment of P16 expressed in E. coli. Specificity: Recognizes human p16. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

E免疫组化免疫印迹

-20°C

1. Bai, F. et al. Mol. Cell. Biol.2003 23, 1269-1277. 2. Lowe, S.W. and Sherr, C.J. Curr. Opin. Genet.2003 Dev.13, 77-83. 3. Sherr, C.J. Nat. Rev. Mol. Cell Biol.2001 2, 731-737