抗体

PAR4 (Prostate apoptosis response 4 protein)

030524

100微升

512美元

单克隆

小鼠

未共轭

13B602

PAR4 (Prostate apoptosis response 4 protein)

小鼠

单克隆抗体

抗体

100微升

512美元

13B602

IgG1

Prostate apoptosis response 4 (Par4) is a 38kD protein originally identified as the product of a gene that is upregulated in prostate tumor cells undergoing apoptosis. It is a leucine zipper and death domain containing protein whose levels increase in neurons undergoing apoptosis as a result of trophic factor withdrawal or exposure to oxidative and metabolic insults. Par4 levels are reported to be increased in their lumbar spinal cord specimens further suggesting a role in neuronal degeneration. The tumor suppressor WT1 represses and activates transcription. The loss and/or imbalance of the dual transcriptional activity of WT1 may contribute to Wilms tumor. Par4 is a WT1 interacting protein that also functions as a transcriptional repressor. Applications: Western Bloting: 1:500-1:2000. Immunohistochemistry: 1:200-1:1000. ELISA: Suggested dilution 1:10000. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Hu

PAWR

Purified recombinant fragment of PAR4(aa1-330) expressed in E. coli.

人类

腹水

Ascites fluid, 0.03% sodium azide.

未确定

Product Type: Mab Isotype: IgG1 Clone No: 13B602 Host: mouse Source: human Concentration: Not determined Form: Ascites fluid, 0.03% sodium azide. Purity: Ascites Immunogen: Purified recombinant fragment of PAR4(aa1-330) expressed in E. coli. Specificity: Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

E免疫组化免疫印迹

-20°C

1. J Biol Chem. 2004 Jul 2;279(27):28266-75. 2. Exp Hematol. 2004 Jul;32(7):649-56. 3. Mol Cell Biol. 2005 Feb;25(3):1146-61. 4. Psychiatr Genet. 2006 Oct;16(5):193-6.